Uncovering the Networks of Topological Neighborhoods in β-Strand and Amyloid β-Sheet Structures 7/24/19
They linked Bader’s quantum theory of atoms in molecules (QTAIM) to the creation of the α-helix structures of peptides via the hydrophobic and aromatic amino acids of Aβ-peptides and the so-called intrinsic ability to form multiple through-space bond paths.
We propose that intrinsic ability to form multiple through-space bond paths is relevant to β-strand/sheet structures that may promote inter-strand association of Aβ peptides. Indeed, some of these bond-path networks were found to be enhanced upon β-sheet formation.
Reported as: Alzheimer’s protein is likely held together with many weak chemical interactions
“This is so strange. It’s outside the common sense of organic chemistry,” said Professor Tomohiko Ohwada from the University of Tokyo
The energy-dependent Creation of Subatomic particles has been linked from the creation of all elements in the Periodic Table and from inorganic chemistry to the Creation of peptides that link the fixation of amino acid substitutions in proteins to protection from the virus-driven degradation of messenger RNA and all pathology in all living genera for ages 10+ in these 4 games:
Subatomic: An Element Building Game
Periodic: A Game of The Elements
Cytosis: A Cell Biology Board Game
Virus Expansion for Cytosis: A Cell Biology Game
Some chemists know that nothing about physics, and chemistry is intrinsic. The Creation of energy is required.
See:
These molecular biologists know that the Creation o f energy is required for changes in base pairs, which they linked to the functional structure of supercoiled DNA:
For comparison to claims about the intrinsic ability to form multiple through-space bond paths. Nobel Laureate, Ben Feringa, senior author of Dynamic control of chirality and self-assembly of double-stranded helicates with light has placed the claims from physics, chemistry, and molecular biology into the context of Biblical Prophesy.
He has helped facts to become perfectly clear to all intelligent serious scientists. Fact 1) The light-activated assembly of the microRNA-RNA-peptide nanocomplex biophysically constrains viral latency and all pathology in species from microbes to humans. Now, every serious scientist knows there is nothing strange about the fact that the Alzheimer’s protein is likely held together with many weak chemical interactions.
All proteins are held together via the light-activated assembly of the microRNA-RNA-peptide nanocomplex, which links the sun’s anti-entropic virucidal energy to biophysically constrained viral latency and healthy longevity in all living genera.
For example, plant growth is sunlight-dependent. This is Fact 2) Meristems are reported to be self-renewing pools of pluripotent stem cells that produce roots, leaves and floral organs. That false fact can now be linked to the false fact that the creation of Alzheimer’s proteins are outside the common sense of organic chemistry.
The people who report that nonsense in the context of the intrinsic ability to form multiple through-space bond paths and self-renewing pools of pluripotent stem cells have no common sense and they have not linked what known about physics, chemistry and biology to healthy longevity. Many of them have linked mutations to evolution, instead.
Neo-Darwinian theorists and Big Bang cosmologists eliminate the creation of sunlight (i.e., energy as information) and water from consideration in the context of the oxygen-dependent growth patterns of different flowers from the same species (sunflowers) and differences in the pink Angel Trumpets. They tout the pseudoscientific nonsense about self-renewing pools of pluripotent stem cells and claim that facts about the Alzheimer’s protein are outside the common sense of organic chemistry.
For comparison, the facts about the light-activated assembly of the microRNA-RNA-peptide nanocomplex will be linked to drug development in a forthcoming presentation by Adrian R. Krainer during the annual meeting of the Society for Neuroscience
See for background information: Antisense Oligonucleotide Therapies for Neurodegenerative Diseases (July 2019)
Antisense oligonucleotides represent a novel therapeutic platform for the discovery of medicines that have the potential to treat most neurodegenerative diseases.
This patent application assured me that naturally occurring RNA interference has the potential to effectively treat all diseases.
RNA-Guided Human Genome Engineering
5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).
After decades of time spent trying to determine the cause of loss of function, some serious scientists have turned towards research on detailed examples of energy-dependent gain of function.
This so-called “novel approach” compares well to what is known about nutrient-dependent pheromone-controlled biophysically constrained viral latency in the context of claims made by Ariel Bazzini in this 6/26/19 Webinar: Genome-Wide Study Reveals a Novel Regulatory Pathway: Translation Affects mRNA Stability in a Codon-Dependent Manner
The forthcoming Special Presidential Lecture: From Base Pairs to Bedside: Antisense Modulators of RNA Splicing to Treat Neurological Diseases will almost undoubtedly not mention the fact that energy-dependent changes in the microRNA/messenger RNA balance were linked from base pairs to the stability of mammalian cell types via EDAR V370A in the mouse to human model of microRNAs in milk exosomes.
Links from human populations in the Old World to the New World were established in: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk
The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.
That fact refutes the pseudoscientific nonsense touted by theorists who claim that energy emerged and that human populations evolved from non-human primates, which is a belief common to secular humanists. However, on 1/17/19, this question was posed by researchers from Iran “Why have microRNA biomarkers not been translated from bench to clinic?” When placed into the context of what is know to people in a theocratic society for comparison to a Republic, such as the Republic of Korea, Adrian R. Krainer’s answer is predictable in the context of what is known to all serious scientists about the light-activated assembly of the miRNA-RNA-peptide #nanocomplex and healthy longevity.
But it is also predictable in the context of what is known about bipartisan politics in the Republic referred to as the United States of America.
The political battle- ground has prevented the dissemination of accurate claims about the energy-dependent microRNA/messenger RNA balance, which
- biophysically constrains viral latency in species from microbes to humans via the physiology of reproduction,
- mediates longevity in the context of the physiology of reproduction, and
- links the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes to healthy longevity.
More people make money from disease than health and that is why microRNA biomarkers have not been translated from bench to clinic?
See also:
Study finds that a protein that helps suppress cancer fades as we age 7/16/15
UCLA researchers have found that a #protein that serves as a suppressor of cancer diminishes in #skin and #mouth epithelial cells as the human body #ages. Dr. No-Hee Park, UCLA School of Dentistry dean and his team have been studying #p53, tumor suppressor protein, “guardian of the genome” involved in DNA repair, cell cycle regulation and cellular deterioration.
“Looking at ways to #maintain levels of p53 as one ages may provide a therapeutic clue to preventing cancer development,” said Park. Previous studies have shown p53 accumulates in large quantities as connective tissue cells, called #fibroblasts, age and stop dividing. It has been believed that the accumulation of p53 causes cells to stop dividing, which prevents out-of-control cells from growing into tumors.
In #epithelial cells lining the skin and the mouth, the level of p53 is reduced, rather than enhanced when cells age. These cells have a set level of p53 that provides protection from environmental factors and ensures their wellbeing. With less p53, older epithelial cells have a harder time maintaining the #integrity of their genetic material when they encounter #carcinogens, which allows cancer to develop. The level of p53 in skin and mouth epithelial cells decreased with age by #epigenetic factors, not by the changes of the p53 DNA sequence.
“In as much as approximately 90% of human cancers are originated from epithelial cells, we suspect this may have to do with the increased incidences of skin and oral cancers in elderly patients,” said Dr. Reuben Kim.
Park and his team also reported that in humans, the level of p53 in skin and mouth epithelial cells decreased with age by epigenetic (external and environmental) factors, not by the changes of the p53 DNA sequence.
RNA-mediated amino acid substitutions stabilize protein folding that is perturbed by the accumulation of viral microRNAs. Nutrient-dependent microRNAs provide the anti-entropic energy that alters the microRNA/messenger RNA balance and leads to fixation of beneficial amino acid substitutions during thermodynamic cycles of protein biosynthesis and degradation that lead to successful reproduction.
Proteins do not create themselves, and they do not evolve. When researchers learn and report the facts about the biophysically constrained chemistry of nutrient-dependent protein biosynthesis and degradation, we will have effective cancer treatment and cancer prevention. Until then, we will continue to see pseudoscientific nonsense reported like this.
…most of the genes differentially expressed in germline deficient C. elegans also show a conserved expression pattern in germline deficient Pristionchus pacificus, a nematode species that diverged from C. elegans 250-400 MYA.
Also see: Criticisms of the nutrient-dependent pheromone-controlled evolutionary model 6/4/14 from Andrew Jones the author of this thesis on the evolution of self-replicating ribozymes
Lipid Encapsulation of Self-Replicating Ribozymes
Based on progress in current research, it is only a matter of time before that “self-replicating” ribozyme is discovered.
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.