Vitamin C and Tet-mediated changes

Timothy W. Bredy’s group just made a giant step forward from ‘Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation.’

With publication of ‘Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation‘ they bring to bear what is currently known by George FR Ellis (see the comments section), Keith BaverstockMichael A. CrawfordDavid Marsh and others, like Denis Noble, about biophysical constraints on ecological adaptations manifested in morphological and behavioral phenotypes. The constraints, somewhat accurately represented by James A. Shapiro, have been ignored by theorists who still seem to not realize that the ‘music of life‘ is nutrient-dependent. There is no orchestration by mutations — despite claims based on theories.

For those who have not followed the information on Tet-mediated changes in differentiation of cell types associated with 5 hmcs, cell-type differentiation is clearly nutrient-dependent, which means that species diversity is nutrient-dependent and pheromone-controlled. Those who have followed the information on Tet-mediated changes may want to see “A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution.”

I mention that since no one would review my 3/13/14 submission on nutritional epigenetics: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems. It was rejected without review even though it was an invited review based on my publication last year of ‘Nutrient-dependent/pheromone-controlled adaptive evolution: a model.’  “Who knows what evil lurks in the hearts…” of social scientists? Who cares?

With new information on Tet-mediated changes in cell types, I was able to include a link from frugivory and adaptive radiation in bats to vitamin C and Tet-mediated changes in human cell type differentiation and adaptive radiation in a population of modern humans.

Author: James Kohl

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