Summary:
Kevin J. Mitchell is a biologically uninformed theorist. Food energy-dependent microRNA-mediated protein crowding in the cell types of human blood links the hemoglobin S variant from a single amino acid substitution to sickle cell disease as an example of all other energy-dependent ecological adaptations, especially the human-specific examples that differentiate you and your relatives from gorillas and other primates.
Light-activated microRNA biogenesis in plants has been linked from autophagy to protection from the virus-driven degradation of messenger RNA, which links mutations to all pathology. See:
The conserved molecular mechanisms of biolphysically constrained viral latency link the creation of subatomic particles to viral latency and healthy longevity via the physiology of reproduction in species from microbes to humans.
See for ages 10+
Cytosis: A Cell Biology Board Game
Subatomic
Periodic: A Game of The Elements
Genotype
After three generations of transgenerational epigenetic inheritance, the player with the most points wins!
The rules of these games — for ages 10+ — and the science behind the games will show you how the food energy-dependent microRNA/messenger RNA balance links the balance between histone acetylation and deacetylation plays to the regulation of chromatin structure and gene expression. For example, histone acetylation is induced by enzymes called histone acetyl transferases (HATs), which activates transcription. For comparison, histone deacetylation is induced by enzymes called histone deacetylases (HDACs), which suppresses gene expression.
There are 18 human-specific HDAC isoforms that link the creation of microRNAs to RNA-mediated amino acid substitutions and the supercoiling of DNA that protects all organized genomes from all virus-driven energy theft, which links mutations to all pathology via modulation of expression microRNAs in all cell types of all individuals of all living genera. DNA gyrase is the enzyme that links the virus-driven degradation of messenger RNA to all pathology via the negative supercoiling of supercoiled DNA.
See: DNA gyrase
Gyrase is the enzyme that harnesses the free energy of ATP hydrolysis, which is how mechanical work on DNA is performeed. The enzyme causes negative supercoiling in the process that links autophagy to coordinated fuel consumption with DNA cleavage and religation via seemingly futile cycles of protein biosynthesis and degradation in the DNA components of a large nucleoprotein complex.
For example:
Structural Dynamics and Mechanochemical Coupling in DNA Gyrase
…type 1A topos are required to inhibit R-loop formation/accumulation mostly to prevent unregulated replication in Ter, and that they are essential to prevent excess negative supercoiling and its detrimental effects on cell growth and survival.
See for comparison: Innate How the Wiring of Our Brains Shapes Who We Are
Kevin J. Mitchell has prepared an attack on the collective intelligence of all serious scientists with claims that the wiring of the brain is “Innate.” His claims ignore the molecular mechanisms of light-activated microRNA biogenesis and protection from the virus-driven energy theft that serious scientists have linked to all pathology. The consequences of his ignorance are severe.
You could be the next to be killed by preventable gun violence, or the last one to die in the forthcoming viral apocalypse. Will Kevin J. Mitchell and others like him be laughing at you as all serious scientists continue laugh at them.
See: m1A and m1G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs
Reported as: DNA’s [energy-dependent microRNA-mediated] dynamic nature makes it well-suited to serve as the blueprint of life
“For something as fundamental as the double helix, it is amazing that we are discovering these basic properties so late in the game,” said Al-Hashimi. “We need to continue to zoom in to obtain a deeper understanding regarding these basic molecules of life.
See also: RNA Structural Modules Control the Rate and Pathway of RNA Folding and Assembly
The energy-dependent response to single nucleotide changes makes RNA folding pathways more prone to alteration. The ubiquitous presence of alternative splicings of pre-messenger RNAs (aka microRNAs) link alternative patterns of folding and the functional assembly of supercoiled DNA to all biophysically constrained biodiversity via the physiology of reproduction. Facts about the energy-dependent biophysically constrained assembly pathways that link supercoiled DNA to protection from all pathology need to be carefully considered in the design of novel structured and functional microRNAs and the RNA-mediated amino acid substitutions that differentiate all cell types in all individuals of all living genera.
See for example: Officials: 3 killed in shooting at Maryland Rite Aid center
The FBI described the Aberdeen incident as an “active shooter situation” and said its Baltimore field office was assisting.
Testing psychologically disturbed potential shooters for COMT Val158Met variants (single amino acid substitutions) would help to prevent active shooter situations. Non-invasive testing is as simple as collecting a saliva sample, and the results can be linked to Precision Medicine across all disciplines
All serious scientists know about this, and many of them know why the testing is not performed. Biologically uninformed theorists have taught other liberals to advocate taking our guns from us, which will leave us to defend ourselves from God-less Communists with our bare hands.
SARCASM ALERT: Remember to wash your hands frequently to protect yourself and your loved ones from genetically engineered viruses until the next Spanish flu epidemic begins. By then, it will probably be too late. Scientific creationists in South Korea have already showed that vaccines do not work, and all serious scientists know why vaccines may cause more harm than good.
See for comparison: Discovery of microRNA-like RNAs during early fruiting body development in the model mushroom Coprinopsis cinerea
Target prediction of the validated milRNAs resulted in genes associated with fruiting body development, including pheromone, hydrophobin, cytochrome P450, and protein kinase. Essential genes for miRNA biogenesis.. were also identified… our findings provided the first evidence for milRNAs in the model mushroom and their potential roles in regulating fruiting body development. New information on the evolutionary relationship of milRNA biogenesis proteins across kingdoms has also provided new insights for guiding further functional and evolutionary studies of miRNAs.”
There is no evolutionary relationship. No aspect of biophysically constrained protection from virus-driven energy theft is innate. Light activated microRNA biogenesis is linked from the physiology of pheromone-controlled reproduction in soil bacteria to the growth of mushrooms and the light-tracking ability of poisonous night-blooming Brugmansia species, which are pollinated by moths.
See also:
Macromolecular crowding: chemistry and physics meet biology (Ascona, Switzerland, 10-14 June 2012)
Cross Talk Between MicroRNA and Coding Cancer Genes
Intronic miRNA mediated gene expression regulation controls protein crowding inside the cell
Beyond the 3’UTR binding-microRNA-induced protein truncation via DNA binding
Summary:
Kevin J. Mitchell is a biologically uninformed theorist. Food energy-dependent microRNA-mediated protein crowding in the cell types of human blood links the hemoglobin S variant from a single amino acid substitution to sickle cell disease as an example of all other energy-dependent ecological adaptations, especially the human-specific examples that differentiate you and your relatives from gorillas and other primates.
See: Biology, molecular and organismic (1964)
Ingram and others found that hemoglobin S differs from A in the substitution of just a single amino acid, valine in place of glutamic acid in the beta chain of the hemoglobin molecule.
That explains why this group is laughing at people like Kevin J. Mitchell, who are among the most ignorant of all biologically uninformed theorists to ever have not linked the creation the the sun’s anti-entropic virucidal energy to all biophysically constrained biodiversity via energy-dependent changes in base pairs.
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.
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