The tipping point (revisited): miRNA-eQTLs

Summary: Food odors and pheromones link the light-activated assembly of the microRNA-RNA-peptide nanocomplex to the physiology of reproduction and healthy longevity via microRNA regulated gene expression unless the virus-driven degradation of messenger RNA links mutations to pathology.

Sex-Interacting mRNA- and miRNA-eQTLs and Their Implications in Gene Expression Regulation and Disease (4/27/19)

…gene expression…has been shown to be modified by sex… and can be investigated through expression quantitative trait loci (eQTLs).

Gene expression is energy-dependent and microRNA-mediated. That requires theorists to place the energy as information-dependent creation of microRNAs (miRNAs) into the ridiculous context of population genetics.

See for comparison: From Fertilization to Adult Sexual Behavior (1996)

We detailed the facts about how alternative splicing techniques of pre-mRNAs contribute to sexual differentiation. The pre-mRNAs are now called miRNAs. Biologically uninformed theorists now claim that sex-interacting mRNA- and ‘miRNA-eQTLs’ alter gene expression regulation and disease.

Ask a theorist where the mRNA and miRNA-eQTLs came from. You will need to accept their claim that miRNAs must be miRNA-eQTLs or their ridiculous theories about sex-interacting mRNA- and ‘miRNA-eQTLs’ explain nothing.

See for comparison:  Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Now you know where energy-dependent microRNAs come from and how they are linked from the light-activated assembly of the microRNA-RNA-peptide nanocomplex to RNA interference and all biodiversity via the physiology of reproduction.

Compare the ridiculous claims about miRNA-eQTLs to claims about RNA interference in the context of this patent application:

RNA-Guided Human Genome Engineering

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

Serious scientist obviously know where RNA comes from and how it protects all organized genomes from the virus-driven degradation of messenger RNA that links mutations to all pathology.

See for comparison: Censorship of biotech researchers? Geneticist Kevin Folta excluded from gardening workshop after orchestrated anti-GMO social media attacks

jvkohl

I’m using light-tracking in Brugmansia (Angel Trumpets) as an example of how light-activated microRNA biogenesis is linked from biophysically constrained fluorescence in P. fluorescens to the growth of flowering plants and the entirety of a model that links sunlight from Schroedinger’s claims in “What is Life?” (1944) to feedback loops via the physiology of reproduction. GMOs alter every aspect of the biophysical constraints that prevent viruses from causing the degradation of messenger RNA that serious scientists have linked from mutations to all pathology.

Kevin Folta

Okay, I’ll bite. What is it in a “GMO” that “prevents viruses from causing the degradation of messenger RNA”? Mechanistically?

I ask because viruses don’t “degrade messenger RNA” — they don’t have the hardware to do that. microRNA is produced through a well described mechanism that I’d think you’d know if you were making such claims. Let’s start there, then explain how all installed transgenes affect that mechanism. Citations required.

jvkohl

Thanks. The fact that viruses are used to create the GMOs links the virus-driven degradation of messenger RNA from unanticipated changes in the microRNA/messenger RNA balance to all diseases in all living genera via the measurement of fluorescence. That’s why researchers from Israel reported that the cure for all cancers is based on “The ability of different peptides to inhibit autophosphorylation of EGFR is presented by the decrease of the fluorescent signal (Y axis).’ http://www.aebi-bio.com/

Also see: McEwen et al (1964) https://www.sciencedirect.c… Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” “The synthesis of RNA in isolated thymus nuclei is ATP dependent.”

Antagonists age 10+ can start about ATP-dependent RNA synthesis by playing Subatomic: An Atom-Building Board Game https://www.kickstarter.com… AND Cytosis: A Cell Biology Board Game https://www.geniusgames.org…

Then, some of us will be on the same page — enough to potentially comprehend the systems biology of nutritional epigenetics in this review.

Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems https://www.omicsonline.org…

Until then, your claim that viruses don’t “degrade messenger RNA” requires a citation to support it and other pseudoscientific nonsense.

Kevin Folta

Here this is simple. What proteins in a virus “degrade messenger RNA”? What is the mechanism?

Please give me the answer and the link that supports it, but not a kooky wild goose chase. I could be wrong, but I don’t know of any such examples.

… and while we ‘re at it, what “viruses are used to create the GMOs”

Poe’s Law is kicking in a bit here, so I’ll keep it short

jvkohl

Stop trying to put words in my mouth by twisting my claims. It’s a tactic commonly used by biologically uninformed theorists until serious scientists usually give up.

Effective: Yes! Incredibly stupid: Yes!

jvkohl

Moving forward. See: Modulation and Evolution of Animal Development through microRNA Regulation of Gene Expression (4/25/19)

“…we review how microRNAs can modulate GRNs during animal development as part of feedback loops”

See also: Feedback loops link odor and pheromone signaling with reproduction (2005)

Summary: Food odors and pheromones link the light-activated assembly of the microRNA-RNA-peptide #nanocomplex to the physiology of reproduction and healthy longevity unless the virus-driven degradation of messenger RNA links mutations to pathology.

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Author: James Kohl

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