The tipping point (revisited): HYL1

Despite all the efforts against it, Sci-Hub grew: currently there are > 400,000 visitors daily, reaching more than half a million sometimes.

Biologically uniformed theorists who use subscription-based services to access publications should try to stay calm after reading: Keep calm and carry on: miRNA biogenesis under stress 4/26/19 doi: 10.1111/tpj.14369

The light-activated assembly of the miRNA-RNA-peptide nanocomplex and

…the miRNA pathway as a whole is subject to regulation in response to external stimulus. In this review, we discuss the current knowledge about the miRNA pathway.

Collaboration among researchers from Argentina and Korea linked the creation of anti-entropic virucidal light from a tissue-biased regulator of plant miRNA biogenesis to methylation and protection of supercoiled DNA via RNA interference.

Cited works include: Achkar, N.P., Cho, S.K., Poulsen, C., Arce, A.L., Re, D.A., Giudicatti, A.J., Karayekov, E., Ryu, M.Y., Choi, S.W., Harholt, J., Casal, J.J., Yang, S.W. and Manavella, P.A. (2018) A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation. Dev Cell, 46, 236-247 e236. doi: 10.1016/j.devcel.2018.06.014

Cho, S.K., Ben Chaabane, S., Shah, P., Poulsen, C.P. and Yang, S.W. (2014) COP1 E3 ligase protects HYL1 to retain microRNA biogenesis. Nat Commun, 5, 5867.

Dong, Z., Han, M.H. and Fedoroff, N. (2008) The RNA-binding proteins HYL1 and SE promote accurate in vitro processing of pri-miRNA by DCL1. Proc Natl Acad Sci USA, 105, 9970-5

Han, M.H., Goud, S., Song, L. and Fedoroff, N. (2004) The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation. Proc Natl Acad Sci USA, 101, 1093-1098.

Su, C., Li, Z., Cheng, J., Li, L., Zhong, S., Liu, L., Zheng, Y. and Zheng, B. (2017) The Protein Phosphatase 4 and SMEK1 Complex Dephosphorylates HYL1 to Promote miRNA Biogenesis by Antagonizing the MAPK Cascade in Arabidopsis. Dev Cell, 41, 527-539 e525.

Vazquez, F., Gasciolli, V., Crete, P. and Vaucheret, H. (2004) The nuclear dsRNA binding protein HYL1 is required for microRNA accumulation and plant development, but not posttranscriptional transgene silencing. Curr Biol, 14, 346-351.

See also: HYL1 Items: 1 to 100+

HYL1 microRNA Items: 1 to 80+

microRNA Items: 1 to 85938+

At the time of this presentation during a virtual conference on Precision Medicine, there were only ~58,000 published works on microRNAs and the link from the creation of sunlight to biophysically constrained viral latency and healthy longevity across kingdoms could not be established in the context of the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes. Published 2/17/17

Thankfully, all interested serious scientists can now follow-up on the claims via  Sci-hub.

I do not advocate its use, nonetheless. They appear to be violating the copyright protection that allows publishers to profit from the works of scientists at the same time few people and fewer institutions can afford to subscribe. Please do not use the dois listed above to find articles that you can read for free. You might get in trouble for doing that. Alternatively, you could purchase the games for ages 10+ that link the creation of energy as information from subatomic particles to cytosis, which protects all organized genomes from the virus-driven degradation of messenger RNA that links mutations to all pathology.

Subatomic: An Atom-Building Board Game
Cytosis: A Cell Biology Board Game

See also:

Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (4/18/18)

Ecological variations and biophysically constrained natural selection for codon optimality links nutritional epigenetics to the behaviors that enable ecological adaptations.

Under a New Light: Regulation of Light-Dependent Pathways by Non-coding RNAs (7/26/18)

Light, photoperiod, and the circadian clock modulate the expression levels of MIRNA genes.

Genome-wide nucleotide patterns and potential mechanisms of genome divergence following domestication in maize and soybean (4/25/19)

This study also presents a first case where a few critical components in genome evolution are brought together: “base composition”, “mutation”, “UV radiation”, “DNA repair”, and “methylation”.

If genomes evolved, there would be no need to link the creation of sunlight from ecological variation to ecological adaptations via links from angstroms to ecosystems in all living genera.

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Author: James Kohl

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