The tipping point (revisited): Genetics & Genomics 2019

High-Amylose Maize, Potato, and Butyrylated Starch Modulate Large Intestinal Fermentation, Microbial Composition, and Oncogenic miRNA Expression in Rats Fed A High-Protein Meat Diet (4/30/19)

All three RS treatments altered the cecal microbial composition in a diet specific manner.

Species-specific differences in diet have consistently been linked from the pheromone-controlled physiology of reproduction in species from microbes to humans to biophysically constrained viral latency and all biodiversity via sympatric speciation.


Get it? The mice are what they eat in the context of the food-energy-dependent microRNA-mediated physiology of their pheromone-controlled reproduction.

That fact was detailed 3 years ago in the context of everything known about RNA-mediated links from physics to chemistry and molecular epigenetics. Unfortunately, very little, if any, scientific progress has been made in the context of Labroots presentations on Genetics & Genomics since this poster session was presented during Genetics & Genomics 2016

Published on 3 May 2016

Olfaction and the innate immune system link energy as information from the epigenetic landscape to the physical landscape of supercoiled DNA. The sun’s biological energy is the source of the information that links angstroms to ecosystems via physics, chemistry, and molecular epigenetics. RNA-mediated protein folding chemistry and amino acid substitutions link the anti-entropic quantized energy of sunlight from the virucidal effects of ultraviolet (UV) light to healthy longevity via biophysically-constrained energy-dependent hydrogen-atom transfer in DNA base pairs in solution and cell type differentiation.

Biomarkers link energy-dependent differences in base pairs and amino acid substitutions to biosignatures across the healthy life span. RNA-mediated amino acid substitutions also reveal the increasing complexity of interactions among cell types as pathology progresses. For comparison, successful reproduction links energy from supercoiled DNA to protection of all organized genomes from virus-driven energy theft and pathology.

This model links the sun’s biological energy from top-down causation in microbes to the most recent model of bottom-up gene activation and cell type differentiation in vertebrates. Citations to extant literature provide examples of what is currently known about how ecological variation leads to biophysically constrained cell type differentiation in the context of nutritional epigenetics and Precision Medicine, which clearly link metabolic networks and genetic networks to pharmacogenomics.

The agenda for Genetics & Genomics 2019 (5/8/19-5/9/19) makes the horrid lack of scientific progress perfectly clear.

No aspect of energy-dependent microRNA-mediated biophysically constrained viral latency and healthy longevity will be presented in the context of games for ages 10+ that link the creation of subatomic particles from cytosis to healthy longevity.

See: Subatomic: An Atom-Building Board Game

See: Cytosis: A Cell Biology Board Game

See also:  Periodic: A Game of The Elements

Wait to link everything known to Genotype

While you wait, watch George Church try to distract you. He linked the light-activated fixation of carbon from the creation of Periodic Table to all biodiversity via the genotype in Church Speaks (2019)

At 15:10:

…the cyanobacteria turn out that they fix light ah as well or better than land plants…

Now, he seems to be at a relative loss for words in this brief overview of the forthcoming conference.

The problem for George Church and others like him is this patent application: RNA-Guided Human Genome Engineering 

It links natural selection for food energy-dependent codon optimality from the creation of sunlight to plant growth via biophysically constrained viral latency.

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

Everything else known to serious scientists about plant growth links biophysically constrained viral latency to healthy longevity, which some people might think would be important to mention during the 2019 Genetics & Genomics virtual conference.

Instead, it is easy to predict differences in the nonsense that will be discussed instead of the facts about microRNA-mediated healthy longevity.

For example, here are my predictions prior to the 2019 Genetics & Genomics virtual conference:

Somatic Gene Recombination in the Brain” will not link Rosalind Franklin’s work with the tobacco mosaic virus to ecological adaptations via “SNVs that are identical to mutations reported in familial AD yet occurring mosaically and somatically.”

Next-Generation Transcriptome and miRNome Sequencing: Intelligent Approaches to Insightful Outcomes” will not be linked from the creation of energy, ATP + RNA to meaningful outcomes via “…differentially-expressed genes/miRNAs, gene fusions or SNPs.”

Nothing known about the link from microRNAs to the virus-driven creation of the death gene in glioblastoma will be presented in “Novel DNA Methylation in Mammals” . But see: Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene (2011)

A Metagenomic Assay to Interrogate the Role of Virome and Microbiome in Cancer” will fail to link “…two signature patterns, one with predominant bacteria and parasites and the other predominant for viruses.” — to all pathology.

The Undiagnosed Diseases Network, which was funded in 2004 by the NIH, will not place the virus-driven degradation of messenger RNA into the context of “The Lessons Learnt and Challenges Faced in the First Four Years

Using Networks to Understand Cancer Risk” will not link the creation of energy to the creation of genes and genetic variants in complex networks. It will link the complex networks to the evolution of ever-changing individual phenotypes.

Michael Snyder will not link microRNA biogenesis to microRNA expression in the context of: ‘… deep longitudinal profiling using advanced technologies can lead to actionable health discoveries and… information relevant for precision health.  See for comparison: Genome-wide identification of microRNA expression quantitative trait loci (2015)

The Progress and Challenge of Satellite DNA Assembly” will not link the light-activated assembly of the microRNA-RNA-peptide from human centromere sequence structure and organization to chromosomal rearrangements and biodiversity.

For comparison, see:

Transcriptional regulation of miR528 by OsSPL9 orchestrates antiviral response in rice (5/2/19)

Many microRNAs (miRNAs) are critical regulators of plant antiviral defense.

But few pseudoscientists are able to do more than link mutations to evolution. They ignore the energy-dependent creation of microRNAs and biophysically constrained viral latency

Fine-Tuning of MiR528 Accumulation Modulates Flowering Time in Rice (5/3/19)

“…distinct mechanisms regulate accumulation of… miR528.”

They exhibited diurnal rhythms at the post-transcriptional level in the context of aging modulated miR528 levels and enhanced pri-miR528 alternative splicing linked to the creation of sunlight.

The targeting of non‑coding RNAs by curcumin: Facts and hopes for cancer therapy (Review) (5/3/19)

The interactions between light-activated microRNA biogenesis and the phytochemical, curcumin are summarized in different cancers and “…the vital noncoding RNAs and their downstream targets are described.”

MicroRNAs as Molecular Switches in Macrophage Activation (4/17/19)

…we highlight the essential molecular mechanisms underlying the different phases of inflammation that are targeted by microRNAs to inhibit or accelerate restoration to tissue integrity and homeostasis.

The highlights refute all theoretical nonsense.

rs895819 in microRNA-27a increase stomach neoplasms risk in China: A meta-analysisv (5/1/19)

…among different ethnicity group, significant relation between rs895819 and gastric cancer was observed in co-dominant model among Chinese population…but not some regions of European population…”

MicroRNA Dysregulation in Cutaneous Squamous Cell Carcinoma (5/2/19)

…we focus on… the role of miRNAs in the development of CSCC [cutaneous squamous cell carcinoma] and in the prognosis of this form of skin cancer.

I linked light-activated microRNA biogenesis to cancer prevention via my skin cancer treatments.

Efficient Epstein-Barr Virus Progeny Production Mediated by Cancer-Derived LMP1 and Virally-Encoded microRNAs (4/30/19)

…cancer-derived LMP1 and viral miRNAs together are necessary for efficient production of progeny virus, and that the resulting increase in efficiency contributes to EBV-mediated epithelial carcinogenesis.

This is a neo-Darwinian theory killer because one amino acid substitution in the influenza virus links the degradation of messenger RNA in the host to a major antigenic change in the virus.

Placing that fact back into the context of evolution exemplifies human idiocy. But see:  Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions.

The amino acid substitutions link the light activated assembly of the microRNA-RNA-peptide nanocomplex to biophysically constrained viral latency and healthy longevity via the physiology of reproduction in all living genera.



Author: James Kohl

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