Food energy-dependent alternative splicings of pre-messenger RNAs, which are also called microRNAs, link the pheromone-controlled physiology of reproduction in species from microbes to humans to biophysically constrained viral latency and all biodiversity on Earth.
See our section on molecular epigenetics in : From Fertilization to Adult Sexual Behavior (1996)
Historical perspective on the role of RNA:
McEwen et al., (1964) told others that:
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
The ATP-dependent synthesis of RNA was subsequently placed into the context of gene-editing technology and evolution.
See: RNA-Guided Human Genome Engineering via Cas9 2/15/13
Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that use short RNA to direct degradation of foreign nucleic acids.
For comparison, see what happened when I linked the creation of ATP to the creation of RNA: RNA-mediated physics, chemistry, and molecular epigenetics 5/3/16
Olfaction and the innate immune system link energy as information from the epigenetic landscape to the physical landscape of supercoiled DNA.
See instead: A universal trend of amino acid gain and loss in protein evolution (2005)
Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.
The claim that amino acid composition of proteins evolves exemplifies human idiocy. The amino acid composition of proteins is food energy-dependent and RNA-mediated in the context of the physiology of reproduction. What excuse do theorists have for not acknowledging that fact or for putting everything known to all serious scientists back into the ridiculous context of evolution?
SARCASM ALERT: It’s been less than one month since the imaginary imagery of the black hole was portrayed as a big data-based example of what pseudoscientists can do if you give them enough money.
On 5/9/19, “Big Data” confirmed the energy that once was found only in light-sucking black holes automagically emerged from nothing. It now links light-activated microRNA biogenesis to all biodiversity via the physiology of reproduction during the same time that humans have automagically adapted to social diversity.
See: Humans adapt to social diversity over time 5/9/19
Humans have evolved cognitive processes favoring homogeneity, stability, and structure.
Biologically uninformed theorists have linked the energy that emerged, which allowed bacteria and archaea to evolve, from adaptive immune defenses and mutations to evolution of biodiversity via adaptations to social diversity.
During his presentation today at the Labroots virtual conference on Genetics & Genomics 2019: I mentioned that intelligent, sane people have asked: Why have microRNA biomarkers not been translated from bench to clinic? (1/17/19)
Then, I asked Michael Snyder:
Do you think that “Big Data” is more important than what is known about light-activated microRNA biogenesis, which links the National Microbiome Initiative to the Precision Medicine Initiative?”
He wrote: They need to be well accepted marker to move to the clinic.
I also asked Michael Snyder:
Do virus-induced changes in the methylome link RNA interference to biophysically constrained viral latency?
He wrote: Great question. We do not know the answer to this.
I also asked:
Does the drop in SpO2 during airline flights cause a change in pH that could link the potential of hydrogen to reactivation of stress-linked infections such as Lyme disease?
He wrote: Another great question. It could lead to a very slight drop in pH. Not sure if that would have an effect on stress-linked infection.
Yesterday, I asked George Church:
How do non-homologous end joining (NHEJ knockouts) for repair of double-strand breaks in DNA compare to naturally occurring food energy-dependent RNA-mediated alternative splicing?
He wrote: NHEJ mutations enable testing of “full nulls”, which are difficult to achieve with RNA-splicing, RNAi, CRISPRi, etc.
From the answers to my questions, it appears that these two experts, George Church and Michael Snyder, are not willing to admit to the fact that the ATP-dependent creation of RNA, links RNA interference to biophysically constrained pH-dependent viral latency and healthy longevity in species from microbes to humans via the conserved molecular mechanisms I have detailed during the past 24 years.
“Big Data” appears to be bigger than life itself, which may continue to lead from more unnecessary suffering to more premature deaths until theorists and other pseudoscientists are willing to accept what is known instead of focusing on what they think is not known, or what they do not want others to know.
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.