The tipping point (revisited): Big Data (1)

Technological advances in omics link the measurement of fluorescence in supercoiled DNA from light-activated microRNA biogenesis to energy-dependent signaling pathways and dynamic changes in angstroms to ecosystems, which biophysically constrain viral latency via ecologically relevant molecular mechanisms.

These advances have been placed into the proper context of microRNAome-driven changes in the microbiome, immunome, metabolome, transcriptome, proteome, and organized genomes of all living genera.

Changes in the microRNA/messenger RNA balance link everything known to serious scientists from top-down creation of the sun’s anti-entropic virucidal energy to classical physics, the basic principles of chemistry, and everything known about molecular epigenetics.  Transgenerational epigenetic inheritance of all morphological and behavioral phenotypes links the fixation of RNA-mediated amino acid substitutions to healthy longevity or to mutation-driven pathology via the fixation of amino acid substitutions in viruses.

No beneficial mutations have been linked to healthy longevity outside the context of mathematical models. For comparison, the virus-driven degradation of messenger RNA links mutations to all pathology.

That fact forced theorists and other pseudoscientists to offer a “Big Data” approach to Precision Medicine. The Big Data approach fails to include energy-dependent cause and effect. That is why Pfaff et. al., tout a hypothesis-free approach to discoveries.

The discoveries that link angstroms to ecosystems have been made. The discoveries link Darwin’s “conditions of life” from what organisms eat to the pheromone-controlled physiology of reproduction in species from soil microbes to humans via energy-dependent feedback loops. Hypothesis-free science is the only approach that can be used in the future to continue to tout the pseudoscientific nonsense of ridiculous theories that cannot be tested. All the untested theories have failed to link food energy from conditions of life to all biodiversity and the virus-driven degradation of messenger RNA to all pathology.

See for comparison:

Ultraviolet Absorption Induces Hydrogen-Atom Transfer in G⋅C Watson–Crick DNA Base Pairs in Solution (2015)
UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair (2016)
Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition

Remember this claim from Pfaff et al., 2019:

…one person, however smart, cannot master everything.

Ask, who, besides Darwin, has come closer to mastery of the facts about how “conditions of life” must be linked from the creation of sunlight to the growth of flowering plants and the food that organisms eat to the pheromone-controlled physiology of reproduction that links feedback loops from angstroms to ecosystems in all living genera.

Then, see: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.



Author: James Kohl

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