The tipping point (revisited): 98K (4)

Word-games and claims about beneficial mutations obfuscate the fact that light-activated carbon fixation is the link to microRNA-mediated viral latency and biophysically constrained ecological adaptations.

See for an example of the word games:  Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments, (2/13/20)

Growth on the inferior carbon source depends on a circuit under the control of a transcription factor that is repressed in the presence of the superior carbon source.

My Translation:

Survival of this species is food energy-dependent and biophysically constrained by the pheromone-controlled physiology of reproduction.

See for comparison: Evolution of Viral Proteins Originated De Novo by Overprinting (2012)

Some of the oldest de novo genes” that must “evolve under stronger selection pressure than the ancestral gene they overlap”

Andreas Wagner’s theoretical nonsense  about beneficial mutations extends from his claims in 2012 to the neo-Darwinian magic of how gene expression noise must create the de novo ancestral genes.

The influence of Jordan et al., (2005) on Wagner’s nonsense is clear.

See: A universal trend of amino acid gain and loss in protein evolution

“Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.”

If the amino acid composition of proteins evolved, it makes sense to claim that all species evolved from the selection pressure experienced by the genes that automagically created themselves before the genes evolved.

But wait, Eugene Koonin was one of the co-authors. He has since addressed the circular logic of his own ridiculous claims and the recent ridiculous claims of Andreas Wagner, who still touts the nonsense about beneficial mutations.

In 2015, Koonin admitted this:

“The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis…”

Really? For comparison, all intelligent serious scientists have learned that

…viral predation has a profound impact on thaumarchaeal functioning and mortality, thereby regulating global biogeochemical cycles.” 

The serious scientists did not ignore what is known about viral predation. They eliminated the Modern Synthesis by including the interactions among viruses, microbes, and all other life forms. That explains why Koonin has since joined the ranks of those who are Combating Evolution to Fight Disease. All intelligent serious scientists know that the integration of mobile genetic elements in Thaumarchaeota is energy-dependent, microRNA-mediated, and biophysically constrained.

See: Integrated mobile genetic elements in Thaumarchaeota 6/2/19

Excerpt:

Gene content analysis revealed an extensive pan‐genome of thaumarchaeal iMGE. The MGE‐specific genes, such as those encoding capsid proteins, viral genome packaging ATPases, conjugation proteins, integrases and so forth, constitute but a small fraction of their gene complements (10%–20% of genes).

Conclusion (senior author Eugene Koonin):

Collectively, our results provide insights into the diversity and evolution of the thaumarchaeal mobilome and illuminate its potential impact on the functioning and adaptation of the host cells.

My summary:

In one sentence, the neo-Darwininan about beneficial mutations and evolution became the Scientific Creationist’s best example of food energy-dependent pheromone-controlled ecological adaptations.

Unfortunately, until the facts about ecological adaptations are accepted by other evolutionary theorists, there is no way for serious scientists/Scientific Creationists to stop the new coronavirus pathology from Wuhan.

Why do atheists & theorists refuse to accept the fact that viruses, amino acids, and proteins do not evolve in the context of gene expression noise? Are they all biologically uninformed science idiots, or fools? Those were rhetorical questions. What’s the difference if theoriests cause the virus-driven death of us all?

See for comparison: Genotype: A Mendelian Genetics Game

Plan your research wisely, demonstrate your knowledge of genetics, and use the harvest schedule to your advantage to excel among your colleagues.

You may also use the growth of Angel Trumpets to exemplify how sunlight and water biophysically constrain oxygen-dependent viral latency during development and their potential for resurrection and multiplication in the next growth season.

See also: Scientists Compare Novel Coronavirus with SARS and MERS Viruses 2/11/20

Reported on Twitter as: The authors found that there were only five nucleotide differences—in a total genome of about 29,800 nucleotides—among the three 2019-nCoV genomes.

They claim to not know “…how the novel coronavirus has mutated and adapted…” but they reveal that one energy-dependent change in one amino acid substitution facilitates the adaptation of the virus to it’s host.

See also this 2013 neo-Darwinian evolutionary theory killer for example. Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions. These single substitutions substantially skew the way the immune system “sees” the virus.

Say goodbye to mutation-driven evolution, atheism and Communism. Say hello again to nutrient-dependent pheromone-controlled ecological adaptations and supercoiled DNA, which biophysically constrains viral latency. For comic relief, see:

See also these additions to the PubMed database via the search term microRNA

Conserved chromosomal functions of RNA interference 2/12/20

These findings have implications for the evolution of RNAi since the last eukaryotic common ancestor, and they provide a more complete view of the functions of RNAi.

The researchers who made that claim come from Cold Spring Harbor Laboratory. They obviously want you to ignore everything about biophysically constrained coronavirus pathology and accept the claim about the “…evolution of RNAi since the last eukaryotic common ancestor…”

If the evolution of RNAi did not occur except in theory, there is no last eukaryotic common ancestor and biologically uninformed evolutionary theorists may still cause the virus-driven death of us all via atheism and Communism.

See how:

The emerging roles of circular RNAs in CNS injuries (2020) comes from researchers working at the Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Did Charles M. Lieber’s collaboration with researchers who were members of the Chinese military help the Chinese move forward from what was known about: The emerging roles of microRNAs in CNS injuries in June, 2013?

See: Biological systems have evolved biochemical, electrical, mechanical, and genetic networks to perform essential functions across various length and time scales.

See also: Harvard University Professor and Two Chinese Nationals Charged in Three Separate China Related Cases

When collaboration among atheists supports ridiculous claims about beneficial mutations and evolution, it is no wonder that Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13 failed to replace theories that were published on the same day in this textbook version of pseudosceintific nonsense: Mutation-Driven Evolution

In my 2013 review, I wrote:

…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, 2012; Duvarci, Nader, & LeDoux, 2008; Griggs et al., 2013; Monahan & Lomvardas, 2012) in adaptive evolution will certainly be discussed in published works that will follow.

Compare ~98,000 publications on microRNA-mediated cause and effect to the claims from Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments

Consider doing that before the virus-driven degradation of messenger RNA, which links mutations to all diseases, kills you and everyone you ever loved via the pseudoscientific nonsense touted by atheists, Communists, and other biologically uninformed science idiots.

See also: Anticancer Activities of the Quinone-Methide Triterpenes Maytenin and 22-β-hydroxymaytenin Obtained from Cultivated Maytenus ilicifolia Roots Associated with Down-Regulation of miRNA-27a and miR-20a/miR-17-5p.

The molecules also induced reactive oxygen species (ROS) and down-regulated microRNA-27a and microRNA-20a/miR-17-5p, corroborating with the literature data for triterpenoids. Intraperitoneal administration of maytenin to tumor-bearing mice did not lead to pronounced histopathological changes in kidney tissue, suggesting low nephrotoxicity. The wide-ranging activity of maytenin and 22-β-hydroxymaytenin in head and neck cancer cells indicates that these molecules should be further explored in plant biochemistry and biotechnology for therapeutic applications.

Alternatively, wait for others to pay billions of dollars for you to Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy 3/3/16 because Harvard researchers patented the  naturally occurring cure for all virus-driven diseases.

“RNAi has targeted exogenous genes in models of viral infection (hepatitis B virus (HBV), influenza virus, Ebola virus) and in tumor xenografts. Initial, RNAi-dependent trials aimed at the delivering siRNA locally or on objects, such as vascular endothelial growth factor (VEGF), for the treatment of the wet age-related macular degeneration and the respiratory syncytial virus (RSV) for the treatment of RSV infections…”

RNA-Guided Human Genome Engineering

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

The problematic identical copies may bankrupt the economy of the USA and other countries before Scientific Creationists convince others to look at the microRNA-mediated cure for all pathology.

Note: Today is day 2 of the 2-day conference organized by Oded Rechavi in an attempt to keep you focused on ridiculous theories.

See: Physiological irrelevant conference

Twitter hashtag

 

Author: James Kohl

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