The tipping point (revisited): 98K (1)

Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia 2/11/20

…new coronavirus (2019-nCoV) infected pneumonia, namely severe acute respiratory infection (SARI) has caused global concern and emergency.

We hypothize that Vitamin C infusion can help improve the prognosis of patients with SARI.

On 2/11/20 These were two of more than 60 additions to indexed published works that attest to the facts about microRNA-mediated prevention and/or control of the new coronavirus crisis from Wuhan and biophysically constrained cancers.

Dietary Restriction and Epigenetics: Part I 12/2/19

Given that numerous age-associated diseases are often polygenic and affect individuals differently, it is possible that they are confounded by interactions between environmental influences and the genome, a process termed ‘epigenetics’.

Epigenetic Regulation by Dietary Restriction: Part II 12/2/19

In the second part of the review, we summarize recent findings that highlight the epigenomic axis of DR, which provides a better understanding of the mechanisms by which its numerous health benefits are achieved.

Vitamin C and Vitamin D were linked to the prevention of all virus-driven pathology in the mouse-to-human model of ecological adaptations via EDAR V370A in: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

See: The Interplay Between Viral-Derived miRNAs and Host Immunity During Infection

…we offer insights into the underexplored role of viral miRNAs as potential targets for developing therapeutics for treating complex viral diseases.

See also:  MicroRNA-155 governs SHIP-1 expression and localization in NK cells and regulates subsequent infiltration into murine AT3 mammary carcinoma

For comparison, on Darwin Day 2020, I hope that others will ask: “What have neo-Darwinian theorists and Big Bang cosmologists done to help prevent any form of pathology?”

Nutrient stress and/or social stress have been linked to all virus-driven pathology by articles like this one:

The stress-activated protein kinase pathway and the expression of stanniocalcin-1 are regulated by miR-146b-5p in papillary thyroid carcinogenesis

See for comparison:

Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Nutrient stress and social stress have been linked to inhibited ATP-dependent RNA synthesis, autophagy, and diseases.

See: MiR-129-3p favors intracellular BCG survival in RAW264.7 cells by inhibiting autophagy via Atg4b

…these data suggested that miR-129-3p could favor MTB survival by inhibiting autophagy via Atg4b.

Conflict of interest: I own the domains Autophagy.pro, microRNA.pro, and RNA-mediated.com

Author: James Kohl

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