The tipping point (revisited): 93K (2)

See: The tipping point (revisited): 93K (1)

I reiterate:

Any approach to species-specific cell type-specific proliferation of cancer cells that does not start with the Creation of energy-dependent biophysical constraints on microRNA-mediated cell type differentiation exemplifies the epic failure of biologically  uninformed science idiots to start with Darwin’s “conditions of life.”

For ongoing follow-ups to what is known to all serious scientists about Darwin’s “conditions of life,” see: New citations to works that mention microRNA

View complete results in PubMed (results may change over time).

On 10/25/19 Sender’s message: 

Sent on Friday, 2019 October 25
Search: microRNA

Your search did not retrieve any items.

Although ~ 1000 published works are added each month, there are days when my search for “microRNA” turns up nothing new. On those days, I look elsewhere.

See for example: Photoinduced hydrogen release from hydrogen boride sheets 10/25/19

Reported as: Hydrogen boride nanosheets: A promising material for hydrogen carrier

…hydrogen can be released in significant amounts (up to eight weight percent) from HB sheets under ultraviolet light, even under mild conditions—that is, at ambient room temperature and pressure.

Polymaths typically consider God’s Creation of energy-as-information before they consider the claim that “…hydrogen can be released in significant amounts… from…”

ANYTHING

Simply put, the hydrogen must be Created before it is released, and hydrogen, so far as is known to intelligent people, did not automagically create itself.

For comparison see: DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering 10/25/19

ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

was reported in Biochimica et Biophysica Acta (BBA) – Specialized Section on Nucleic Acids and Related Subjects (1964)

See McEwen et al. Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

All serious scientist know that the light-activated synthesis of RNA links “ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering” from RNA interference to DNA repair.

No matter how attempts to obfuscate cause and effect via changes in phrases and terms have been made, you can see for clarification:

UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair 1/13/16

…repair capacities are strongly sequence-dependent, creating DNA regions with different tendencies of self-repair. This self-healing activity represents the simplest sequence-dependent DNA repair system.

Note: It’s not really self-repair outside the context of the sun’s anti-entropic virucidal energy, which links the light-activated assembly of the microRNA-RNA-peptide nanocomplex to:

Control of pH responsive peptide self-association during endocytosis is required for effective gene transfer 12/29/11

and to the Physicochemical mechanism of light-driven DNA repair by (6-4) photolyases. 12/16/13

In the early 1990s, two different mentors taught me to link energy-dependent gene activation from effective gene transfer to the enzyme-dependent metabolism of nutrients and the peptide pheromone-controlled physiology of reproduction in rats.

An extended conversation about my model during a meeting in Las Vegas with Bruce S. McEwen, led to to an extended phone conversation and several meetings with Robert L. Moss from Texas.

Initially, Dr. Moss gave his permission to me to forward three preprints to Dr. McEwen in an attempt to determine whether anything more might be required to validate my model.

The preprints were subsequently published as:

Gonadotropin releasing hormone and human sexual behavior (1991)

Induction of FOS immunoreactivity in central accessory olfactory structures of the female rat following exposure to conspecific males (1992)

Influence of male rats on the luteinizing hormone-releasing hormone neuronal system in female rats: role of the vomeronasal organ (1993)

It soon became clearer that mammalian pheromones were the link from what different species, such as mice, ate to:  Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.) (1994)

Peptide pheromones in the gut microbes of mammals were linked from the enzyme-dependent metabolism of food in other species to the nutrient-dependent creation of peptide pheromones. The experimental evidence continued to support claims that linked the physiology of reproduction in single-celled organisms  to  human longevity via conserved molecular mechanisms in nematodes and all other model organisms. The conserved molecular mechanisms were first portrayed in the context of Charles Darwin’s “conditions of life.”