The tipping point (revisited): 93K (1)

Historical perspective: Targeted photoredox catalysis in cancer cells 9/23/19

On light irradiation, complex 1 induces NADH depletion, intracellular redox imbalance and immunogenic apoptotic cancer cell death. This photocatalytic redox imbalance strategy offers a new approach for efficient cancer phototherapy.

Details of this on Twitter have led to a recent dramatic decline in the number of impressions made. It’s like being told, “Go away, you’re bothering me.”

See: Photoinduced hydrogen release from hydrogen boride sheets (2019).

Reported as: Hydrogen boride nanosheets: A promising material for hydrogen carrier 10/25/19

…hydrogen can be released in significant amounts (up to eight weight percent) from HB sheets under ultraviolet light, even under mild conditions—that is, at ambient room temperature and pressure.

Before it can be released, it must be Created. Unless theorists can show how hydrogen created itself, its light-activated release can be linked to the Creation of all biodiversity on Earth via the physiology of reproduction in all living genera.

See also: The tipping point (revisited): 92K (1) 9/27/19 and The tipping point (revisited): 92K (2) 9/30/19

Moving forward: KB Whaley (54 indexed publications) is now a member of President Donald Trump’s Council of Advisors on Science and Technology.

See for example:  Molecular Mechanics Simulations and Improved Tight-Binding Hamiltonians for Artificial Light Harvesting Systems: Predicting Geometric Distributions, Disorder, and Spectroscopy of Chromophores in a Protein Environment 12/17/18

The link from artificial light-harvesting systems to the patented cure for cancer may not be understood by non-polymaths. But see: Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest 12/25/18

See also their Proof of concept

The effect of several peptides on the phosphorylation levels of human EGFR in A431 cell line was assessed…

AND

The ability of different peptides to inhibit autophosphorylation of EGFR is presented by the decrease of the fluorescent signal (Y axis).

They linked light-activated microRNA biogenesis from the light-activated assembly of the microRNA-RNA-peptide nanocomplex to biophysically constrained viral latency and the prevention of all pathology via the measurement of fluorescence.

Update: microRNA Items: 1 – 92945

Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene.

The Creation of sunlight and water links the light-activated assembly of the microRNA-RNA-peptide nanocomplex to oxygen-dependent enzyme-dependent ecological adaptations. One base pair change and one amino acid substitution in one enzyme is all that is required for a host to adapt to a virus.

For an example in plants, see: miR156-targeted SPL10 controls root meristem activity and root-derived de novo shoot regeneration via cytokinin responses 10/23/19

First sentence:

Root growth is modulated by different factors, including phytohormones, transcription factors, and microRNAs (miRNAs).

Concluding sentence:

Our results reveal a cooperative regulation of root meristem activity and root-derived de novo shoot regeneration by integrating age cues (via miR156-targeted SPL10) with cytokinin responses.

There is no such thing as “de novo shoot regeneration.” Regeneration requires energy-dependent RNA-mediated DNA repair.

See: Human ribonuclease Dicer – structure and functions 10/1/19

…Dicer is involved in processing of diverse classes of RNA, including tRNA and snoRNA, cleavage of repeat-element-derived RNAs, and maintenance of genome integrity. Dicer has also been found to participate in the chromosome fragmentation during apoptosis or in the inflammatory processes. More­over, a recent discovery of Dicer-binding passive sites in mRNAs and long non-coding RNAs, and its putative nucleic acid chaperone activity, has pointed out a novel regulatory role of the enzyme.

Failed energy-dependent RNA-mediated DNA repair leads to all cancers.

See for example:

miR-559 polymorphism rs58450758 is linked to breast cancer 10/23/19

Researchers from Iran linked one virus-driven base pair change, rs58450758 to a microRNA-mediated changes in enzyme structure and new DICER sites linked to constraint-breaking mutations and breast cancer.

Energy-dependent RNA-mediated DNA repair is the cure for all pathology, including all cancers.

Harnessing therapeutic viruses as a delivery vehicle for RNA-based therapy 10/23/19

Messenger RNA (mRNA) and microRNA (miRNA)-based therapeutics have become attractive alternatives to DNA-based therapeutics…. Also, RNA-based therapeutics are considered safe since there are no risk of inducing genomic changes…. We have developed a delivery platform for RNA-based therapeutics by exploiting the physicochemical properties of enveloped viruses. By physically attaching cationic liposome/RNA complexes onto the viral envelope of vaccinia virus, we were able to deliver mRNA, self-replicating RNA as well as miRNA inside target cells.

See also: Silencing CASC11 curbs neonatal neuroblastoma progression through modulating microRNA-676-3p/nucleolar protein 4 like (NOL4L) axis. 10/23/19

…hinting a CASC11-mediated therapeutic target for neonatal neuroblastoma.

All therapeutic targets are microRNA-mediated via the light-activated assembly of the microRNA-RNA-peptide nanocomplex. Amino acid substitutions in peptides are the obvious link to biophysically constrained viral latency and healthy longevity. Energy-dependent fixation of the amino acid substitutions in organized genomes links sympatric speciation to all biodiversity on Earth.

See: Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination 10/22/19

Our findings provide evidence supporting a critical role for a steady-state level of OL-specific miR-27a in supporting multiple steps in the complex process of OPC maturation and remyelination.

Remyelination is energy-dependent and biophysically constrained by iodine in the context of the role that thyroid hormone plays in the regeneration of tissues in salamanders, such as the Darwinian “walking fish.”

Meet the creature that can regenerate its brain and resist cancer

For comparison to everything currently known to serious scientists about the prevention of all pathology, see:

GSK-3 modulates SHH-driven proliferation in postnatal cerebellar neurogenesis and medulloblastoma10/10/19

…a GSK-3/WNT axis modulates the developmental proliferation of CGNPs and the pathological growth of SHH-driven medulloblastoma.

Reported as: Researchers identify possible approach to block medulloblastoma growth 10/24/19

“For one of the more common subtypes of medulloblastoma, we found we can target a to block tumor growth,” said Jennifer Ocasio, Ph.D., the study’s first author and a former graduate student in the UNC School of Medicine Neuroscience Curriculum. “By targeting this pathway, we think this would be a way to sidestep effects of radiation and chemotherapy that have a lot of side effects because we are blocking growth rather than killing these .”

All signalling pathways are energy-dependent and microRNA-mediated in the context of biophysically constrained viral latency.

Any approach to species-specific cell type-specific proliferation of cancer cells that does not start with the Creation of energy-dependent biophysical constraints on microRNA-mediated cell type differentiation exemplifies the epic failure of biologically  uninformed science idiots to start with Darwin’s “conditions of life.”

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