The tipping point (revisited): 89K (5)

Dynamic control of chirality and self-assembly of double-stranded helicates with light (2016) links light-activated microRNA biogenesis from the creation of the sun’s anti-entropic virucidal energy to RNA-mediated biophysically constrained viral latency via RNA interference.

See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

For a historical perspective on epigenetically-effected ATP-dependent RNA interference, see: Epigenetic Control Systems (1958)

July 15 is the anniversary date. DL Nanney presciently linked epigenetic effects of food to viral latency via Effects of Carnitine on Fatty-Acid Oxidation by Muscle (1959) and the epigenetic effects of Pheromones’: a new term for a class of biologically active substances  (1959) were linked to healthy longevity in [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)]. (1994)

Moving forward, see also: Peptide ligation by chemoselective aminonitrile coupling in water 7/10/19

Our model unites prebiotic aminonitrile synthesis and biological α-peptides, suggesting that short N-acyl peptide nitriles were plausible substrates…

The endogenous substrates have been linked to the origin of platelets and the eutherian placenta.

See:  The origin of platelets enabled the evolution of eutherian placentation 7/10/19

All neonatal mammals, regardless of how developed they are at birth, rely on maternal lactation for their initial growth and survival after birth, and thus, the survival of the mother is critical.

Platelet-linked survival of the mother can be compared to survival of the queen in eusocial insects that are also epigenetically effected by climate changes.

See:  Climate change impacts on bumblebees converge across continents 7/10/15

Using long-term observations across Europe and North America over 110 years, we tested for climate change–related range shifts in bumblebee species across the full extents of their latitudinal and thermal limits and movements along elevation gradients.

The climate-related shifts that parallel latitudinal and thermal limits of movements along elevation gradients were linked to mammalian species via microRNAs in milk exosomes.

See: Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns 7/27/18

See also: Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant  2/14/13 and Identifying Recent Adaptations in Large-Scale Genomic Data 2/14/13

The human-specific EDAR V370A allele was linked from ecological adaptations in mice and other mammals to recent adaptations in in North and East Asian and New World populations via Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk 5/8/18.

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection…

The link from natural selection for energy-dependent codon optimality to protection from the virus-driven degradation of messenger RNA, which links mutations to all pathology has been place into the context of Global phylogeography and ancient evolution of the widespread human gut virus crAssphage and Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis

The energy-dependent creation of peptides in water has been linked from the light-activated creation of ATP, RNA  to the microRNA biogenesis and the genesis of all biodiversity via the physiology of reproduction in species from microbes to humans. The origin of platelets links food energy-dependent pheromone-controlled biophysically constrained viral latency to eutherian placentation via ecological adaptations across continents that link the EDAR V370A allele from the mouse to the human model of: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)

Natural selection for food energy-dependent codon optimality is the only known link to ~5300 years of ecological adaptations in all species on Earth.

See for comparison to claims about the automagical creation of self-replicating ribozymes made by the biologically uninformed science idiot Andrew Jones in Lipid Encapsulation of Self Replicating Ribozymes (2012)

Despite their challenges, ribozymes have made an interesting niche for themselves in the field of abiogenesis. The evolution of a successful RNA polymerase ribozyme is a lofty goal. While its discovery would not be the be-all and end-all of abiogenesis research, it would represent an important stepping stone between prebiotic chemistry and life. The encapsulation of such a ribozyme is also an important step, as it would enable a system of heredity and evolution through natural selection. Based on progress in current research, it is only a matter of time before that ribozyme is discovered.

Claims about the emergence of energy and the automagical creation of self-replicating ribozymes made by the biologically uninformed science idiot, Andrew Jones, can be compared to the claims in: Feedback loops link odor and pheromone signaling with reproduction(2005)

The feedback loops were presciently included in Darwin’s “conditions of life.”

The claims were revisited in:Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet 1/22/16 and in: miRNAs in ancient tissue specimens of the Tyrolean Iceman 12/28/16

Our first comprehensive analysis of microRNAs in ancient human tissues indicates that these stable molecules can be detected in tissue specimens after 5,300 years.

No experimental evidence of biophysically constrained viral latency extends to neo-Darwinian theories of mutation-driven evolution or theories that link Big Bang cosmology to the origin of energy as information.

Instead, Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants links microRNAs in milk exosomes the the stability of all organized genomes in the mouse to human model of nutrient-dependent pheromone-controlled reproduction from 1994. [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)].

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