The tipping point (revisited): 88K (3)

The Woman Who Revealed the Missing Link Between Viruses and Cancer 6/17/19

In 1911, virologist Peyton Rous discovered the Rous sarcoma virus, which he concluded could transmit cancer in chickens. In 1933, Richard Shope, a physician and virologist, discovered the Shope papilloma virus, which caused keratinous carcinomas in rabbits, and three years later, biologist John Bittner demonstrated that the mouse mammary tumor virus could be transmitted from a mother mouse to her young through her milk. But it was Ludwig Gross’s work on leukemia in mice in the 1950s that would lead to the first major breakthrough in the virus-cancer link—and it was that work that Stewart took up when she moved to the NCI in 1951.

The breakthroughs led Sarah Stewart to help develop a cancer-causing HPV vaccine.

For comparison, the transgenerational epigenetic inheritance of the mouse mammary tumor virus from a mother mouse to her young through her milk is biophysically constrained.

See: Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns

Exosomes and their RNA cargos do not exclusively originate from endogenous synthesis but may also be obtained from dietary sources such as the inter-species transfer of exosomes and RNAs in bovine milk to humans.

The transfer of microRNAS in milk exosomes obviously helps to protect all mammals from viruses in this context:

Feedback loops link odor and pheromone signaling with reproduction (2005) and [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)] (1994)

A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.

The mouse-to-human model of nutrient-dependent pheromone-controlled biophysically constrained viral latency was published as: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems

Biophysically constrained viral latency has since been linked from the human-specific EDAR V370A allele to populations from the Old World to the New World.

See: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk (2018)

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection…

See for comparison: Positive psychotic symptoms are associated with divergent developmental trajectories of hippocampal volume during late adolescence in patients with 22q11DS (6/4/19)

Reported on 6/17/19 as Schizophrenia: Adolescence is the game-changer

The virus-driven degradation of messenger RNA links the COMT Val158Met allele to prevention of schizophrenia, school shootings, and suicides.

See also: comt val158met  Items: 1 to 898

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Author: James Kohl

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