A multicellular way of life for a multipartite virus (3/12/19)
…the viral genome is not recapitulated in a single virus particle but in the viral population.
This facilitates adaptations in the viruses that are delivered in vaccines or acquired through naturally occurring exposure. Natural selection for energy-dependent codon optimality is the only known protection from the viruses.
See: Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition (7/19/16)
The ATP-dependent creation of RNA and the energy-dependent microRNA-mediated physiology of reproduction links fixation of RNA-mediated amino acid substitutions to the differentiation of all cell types in all individuals of all living genera. Alternatively, the virus-driven degradation of messenger RNA links mutations to all pathology.
That fact was reported as: Viruses Can Scatter Their Genes Among Cells and Reassemble (5/21/19)
For comic relief, see:
Something — presumably, the diffusion of molecules among the infected cells — allows complete viral particles to replicate, self-assemble and infect anew.
Nothing self-assembles. Energy is required. Viruses steal the energy that is required for the creation of base pairs and cell type differentiation. The level of ignorance expressed in comments about self-assembly is intolerable to conservatives.
But, see also: Shocked by the rise of the right? Then you weren’t paying attention (5/24/19)
The seeds of Trump, Brexit and Modi’s success were sown by endemic racism and unfairness. Tackling that is the answer
The ignorance of the left was revealed by evidence that vaccines and gene-editing allow viruses to steal the anti-entropic energy that biophysically constrains them, and use it to reassemble into more virulent strains that are the source of all diseases.
Who didn’t see that coming? Here’s evidence of someone who did:
Whistleblower, prominent Atlanta doctor goes missing after flu warning (2/26/18)
See these selected publications from the late Timothy J. Cunningham who was about to expose the corruption at the CDC when he suddenly disappeared.
1)”Racial Disparities in Age-Specific Mortality”
2) “Sex-specific relationships between adverse childhood experiences”
3) “Associations between antioxidants and all-cause mortality”
and
4) “Health and Safety Issues for Travelers”
All racial/ethnic disparities are food energy-dependent and microRNA-mediated in the context of amino acid substitutions in peptides that differentiate all cell types in all living genera — including sex differences in cell types.
Another man with the same name as the late Timothy J. Cunningham, has studied cell death and RNA-mediated DNA repair for over 35 years. He is the first author of: Anti-Inflammatory Peptide Regulates the Supply of Heat Shock Protein 70 Monomers: Implications for Aging and Age-Related Disease (4/1/15)
Additional support for an enzymatic mechanism underlying CHEC-9 activity was found by inspection of the peptide’s amino acid sequence: Cys-His-Glut-Ala-Ser-Ala-Ala-Gln-Cys. This familiar motif consisted of a “catalytic” histidine followed by a metal-binding acidic residue (glutamic or aspartic acid) and flanked by stabilizing cystines.
Similarly, the stability of all organized genomes in all vertebrates with jaws has been attributed the the substitution of achiral glycine in position 6 of the gonadotropin releasing hormone (GnRH) decapeptide.
pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Many researchers fail to report that designation of chirality, because they assume that all amino acids are in their L- form. The instability of the L-forms is tractable. For example, bacteria and archaea, become L-forms: cells without walls in the last stage of what appears to be the virus-driven degradation of messenger RNA, which is typically prevented in jawed vertebrates via the substitution of one amino acid: GLYCINE.
Chemistry Nobel Laureate, Bernard Feringa helped to bring forward the issue of light-controlled chirality.
See: Dynamic control of chirality and self-assembly of double-stranded helicates with light (11/7/16)
The food energy-dependent substitution of achiral glycine was previously placed into the context of evolution, but not the light. See: Evolution of Constrained Gonadotropin-releasing Hormone Ligand Conformation and Receptor Selectivity (2005)
These findings indicate that the substitution of glycine for a chiral amino acid in GnRH during evolution allows a more constrained conformation for receptor binding and that this subtle single amino acid substitution in a site remote from the ligand functional domains has marked effects on its structure and activity.
These researchers assumed that the light-activated constraints on achiral glycine did not matter and claimed:
During at least 600 million years of evolution the N and C termini of GnRH have been conserved as functional domains for binding and activating cognate receptors to accomplish these functions.
The biologically uninformed science idiot, Laurence A. Moran, linked the accidental creation of achiral glycine to the evolution of all vertebrate biodiversity in all vertebrates with jaws.
What he claims was an accident somehow started with the spontaneous formation of glycine or the biophysically constrained energy-dependent creation of all life on Earth.
For comparison see: Evolution of gonadotropin-releasing hormone (GnRH) structure and its receptor (3/15/12)
The discovery of the fact that one decapeptide molecule, among the GnRHs, was constructed perfectly at the beginning of 400 million years evolution and that it is not possible to improve its physiological potency using the any natural amino acid is, in my opinion, important, fascinating and beautiful.
Others have linked the importance of the discovery of achiral glycine in the GnRH decapeptide from The Miracles Of Smell And Taste to our visual perception of energy and mass in the context of the space-time continuum via the pheromone-controlled physiology of reproduciton in species from microbes to mammals. The levels of complexity are overwhelming.
For example, however, the fact that Evolutionists Cannot Account for the Origin of the Sense of Smell can now be placed into the context of Olfaction Warps Visual Time Perception link opens pdf
“In physics, space-time is warped by the distribution of mass and energy in it (Hwaking 1988). Our findings, along with others (Johnston et al. 2006; Xuan et al. 2007; Wang and Jiang 2012; Mayo and Sommer 2013), suggest a parallel in the perception of time––subjective time is “warped” by the neural energy involved in representing multisensory inputs at subsecond scales.”
The energy-dependent creation of achiral glycine links the neural energy from peptidergic constraints to epigenetic effects on viral latency by feedback loops. See: Feedback loops link odor and pheromone signaling with reproduction
The virus-driven creation of toxic peptides links the degradation of messenger RNA to all pathology in all cell types of all living genera. If not for the protection of organized genomes by light-activated changes in chirality and microRNA biogenesis, viruses would already have caused the extinction of all life on Earth. The fact that Viruses Can Scatter Their Genes Among Cells and Reassemble probably is the key to our future.
For a historical perspective see: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants (11/28/12)
See also: Past 5,000 years prolific for changes to human genome
The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.
The findings do not confirm any earlier works that suggested species with ecologically relevant magic traits evolved to become other species.
See also: An olfactory virtual reality system for mice (2/26/18).
This capability provides a way forward for studying how basic features of an environment, such as sensory variability, can inform the neural representation of a behavior.
Brain can navigate based solely on smells (2/26/18)
The olfactory-based virtual reality system could lead to a fuller understanding of odor-guided navigation and explain why mammals have an aversion to unpleasant odors, an attraction to pheromones and an innate preference to one odor over another.
The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection…
Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns
Exosomes and their RNA cargos do not exclusively originate from endogenous synthesis but may also be obtained from dietary sources such as the inter-species transfer of exosomes and RNAs in bovine milk to humans.
Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems
The ecological adaptations, which appear to be manifested in the human population are detailed in these two reports [159,160]. The [EDAR V370A-linked] ecological adaptations are likely to be nutrient-dependent and pheromone-controlled. If so, ecological variation probably leads to ecological, social, neurogenic, and socio-cognitive niche construction, which is manifested in increasing organismal complexity and species diversity. If not, there may be something as yet unknown about mutations and evolution that makes sense in the light of what is known about nutritional epigenetics and the molecular biology of species from microbes to man.
See also: microRNA Items: 1 to 20 of 86975+
For example:
Dietary microRNA-A Novel Functional Component of Food (5/23/19)
See also, rrom an attempt to discuss the facts on Twitter:
Eshel Ben-Jacob was also a member of the International Paleopsychology Project at the time I first encountered Greg Bear. Eshel is the senior author of “MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination” (2013)
None of the claims about how the virus-driven degradation of messenger RNA is linked to all pathology are taken seriously by pseudoscientists or other theorists. My Twitter feed of 15.6K Tweets attests to that fact.
See microRNApro
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.