The tipping point (revisited): 85,000 publications


Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death (1/25/19)

…various activators and modulators of NR4A2 have been discovered and investigated as probable therapeutic drugs in neuroinflammatory and neuronal cell death models. The NR4A2 gene and cell-based therapy are described as promising drug candidates for neurodegenerative diseases. Moreover, microRNA might have a crucial role in neurodegeneration via affecting NR4A2 expression.

Other researchers from South Korea, which is the so-called “creationist capital of the world,” have linked the Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events to the inability to create effective vaccines.

The problem is that viruses ecologically adapt in different hosts. Vaccinations in one host cause ecological adaptations in viruses and increased virulence in other hosts, unless the host species adapts. The only hope for prevention of the virus-driven degradation of messenger RNA  across species must be linked from this report to the target that is the cause of the disease: the virus-driven creation of the death gene.

Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene (9/14/11)

…the data presented here provide a comprehensive analysis of the miRNA signature in glioblastoma and demonstrate the potential application of miRNA-regulated genes in the therapeutic treatment of brain cancers— an approach that could be readily extended to cancers of other organs.

The molecular insights that link biophysically constrained viral latency to targeted healthy longevity have been placed into the context of how the virus-driven degradation of messenger RNA in Pseudomonas aeruginsa is linked to all pathology in all living genera via the pheromone-controlled physiology of reproduction.

See: Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection (3/29/19)

These findings may have broad utility and impact beyond the pathophysiology of chronic wound infections. Pa is a major pathogen in other clinical settings as well, including lung infections in cystic fibrosis. Moreover, many other Gram-negative bacteria, including Klebsiella pneumoniae, Salmonella enterica, Vibrio cholerae, and Escherichia coli, have the capacity to harbor similar filamentous phage (genus Inovirus). Indeed, several of these phage are known to contribute to the virulence potential of their host bacteria. We propose that filamentous phage may be relevant to human interactions with a broad range of pathogenic and commensal bacteria and that these viruses may have profound, direct effects on human health and disease.

Simply put, bacteriophages (viruses in bacteria) damage the DNA of P. aeruginosa and that damage has been linked to direct effects on human health and disease via conserved molecular mechanisms. The mechanisms link the physiology of pheromone-controlled reproduction in bacteria to the physiology of pheromone-controlled reproduction in humans.

In the absence of stress-linked viral replication, the light energy-dependent assembly of the bacterial flagellum in P. fluorescens links beneficial effects on plant growth to biophysically constrained viral latency.

See: Fluorescence amplified sensing platforms enabling miRNA detection by self-circulation of a molecular beacon circuit (3/19/19)

The molecular beacon (MB) circuit links the light-activated assembly of the microRNA-RNA-peptide nanocomplex to all biophysically constrained biodiversity via energy-dependent effects on transgenerational epigenetic inheritance. The effects can be measured in the context of the measurement of fluorescence.

Accelerated Evolution Biotechnologies 

The ability of different peptides to inhibit autophosphorylation of EGFR is presented by the decrease of the fluorescent signal (Y axis).

See also: RNA editing in plants: A comprehensive survey of bioinformatics tools and databases

RNA editing is a widespread epitranscriptomic mechanism by which primary RNAs are specifically modified through insertions/deletions or nucleotide substitutions. In plants, RNA editing occurs in organelles (plastids and mitochondria), involves the cytosine to uridine modification (rarely uridine to cytosine) within protein-coding and non-protein-coding regions of RNAs and affects organelle biogenesis, adaptation to environmental changes and signal transduction.

See also: Remarkable Photos Capture the Light That Plants Emit

The link from light-induced energy-dependent changes in photons to fluorescence is not discussed in the context of links from microbes to the development of the human brain. Pseudoscientists do not want you to know how RNA editing in plants is linked to all biophysically constrained biodiversity on Earth via the physiology of reproduction in all genera.

Researchers trace origin of blood-brain barrier ‘sentry cells’

Although their function is not completely understood, a special population of cells covering the blood vessels on the brain’s surface is thought to contribute to the organ’s protection. The cells act as sentries, engulfing toxins, cellular wastes and microbes and then encasing them in sphere-like structures called vesicles. These sentry cells are called fluorescent granular perithelial cells (FGPs) because the vesicles they contain give off a yellow glow in the presence of light.

Light-induced fluorescence links the nutrient energy-dependent pheromone-controlled physiology of reproduction from quorum sensing to the weekend evolution of the bacterial flagellum in Pseudomonas fluorescens, which is linked to UV light-protected human brain development.

The conserved molecular mechanisms of biophysically constrained biologically-based cause and effect were detailed in our 1996 Hormones and Behavior review. From Fertilization to Adult Sexual Behavior

All serious scientists could link the weekend resurrection of the flagellum to the weekend Resurrection of Christ via what is known about how the microscopic world must be linked to what is known about gene expression and the phenotypes of all living genera.

For example, see Ben Feringa’s link to Biblical prophesy:

Disabled were walking again, the blind were seeing again, and the death rose from the grave. 2013 was the year in which prophesy from the bible became reality. — De Correspondent dec 2013

Clearly, all morphological and behavioral phenotypes are energy-dependent and the phenotypic expression is controlled by the physiology of reproduction.

That fact has not changed since the beginning of time. Theories about energy-dependent RNA-mediated cell type differentiation seem to be changing every week. When they don’t change, the theorists simply claim that the function of specific cell types is not completely understood. That is a lie. All differentiated cell types are linked to survival of the species. The virus-driven degradation of messenger RNA links undifferentiated cell types to all pathology.

See for comparison: “Diet, Genes and Your Health: Unlock Your Genetic Potential by Using the Science of Epigenetics

See also:

Kohl and Francoeur at 25 (4) 3/29/19

Kohl and Francoeur at 25 (3) 3/28/19

Kohl and Francoeur at 25 (2) 3/27/19

Kohl and Francoeur at 25 (1) (3/21/19)

Author: James Kohl

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