The tipping point (revisited): 82,000 publications (2)

RE: …medical professionals would need to learn how light-activated microRNA biogenesis in plants is linked to the prevention of all diseases in all species via RNA-mediated amino acid substitutions in nearly 82,000 published works.

Age-related diseases are being addressed in the context of the Delivery of 45 Age Reversing Gene Therapies at Once is Under Peer Review (video)

This is the work that Nextbigfuture has been expecting from George Church’s company Rejuvenate Bio.

Unless serious scientists from South Korea and Iran stop him, the work will be linked to the company’s profits in the context of Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy, because

RNAi has targeted exogenous genes in models of viral infection…

See: RNA-Guided Human Genome Engineering” George M. Church et. al, (2015)

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems…

Serious scientists know what George M. Church and others are doing.  Serious scientists do not target endogenous viral elements (e.g., HERVs) until after they accept the facts about “Energy as information and constrained endogenous RNA interference”

After serious scientists accept the facts about food energy-dependent biophysically constrained viral latency, they link changes in energy of photons (light) from changes in electrons and other subatomic particles to changes in angstroms and ecosystems in all living genera.

See: Structural diversity of supercoiled DNA

For comic relief and fun with theorists see:

If you are a theorist, see also:

If you value relatively useless mathematical models, see: Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

…results provide a solid starting point to evaluate the effects of these loci in model organisms…

Chemists, and molecular biologists are not likely to go back to any starting point that does not include what they know about the energy-dependent dynamics of particle physics and mitochondrial biogenesis, which must be linked to autophagy.

All serious scientists know that all models of behavior must begin with the creation of energy and link the energy to the behavior. Only biologically uninformed theorists think they can start with genes and mutations.

For example, George M. Church started with light-activated carbon fixation and selection for naturally occurring energy-dependent codon optimality. As Feynman claimed on several different occasions, I do not understand how to explain that in terms that you may be familiar with.

Why is any explanation required now that George M. Church has accepted the facts of life and he has expressed his intent to profit from his understanding of epigenetics and genetics via the patent.

If you would like to speak with him directly about that, first listen to: Church Speaks: A Conversation With George Church [2.14.18]

At 15:10:

…the cyanobacteria turn out that they fix light ah as well or better than land plants…

From the transcript:

The cyanobacteria fix [carbon via] light as well or better than land plants. Under ideal circumstances, they can be maybe seven to ten times more productive per photon.

The claim that interactions among the subatomic particles, electrons and photons, are required to create enzymes in the context of fixation of light to carbon, which links photons and electrons to all energy-dependent life on Earth is obfuscated. He says:

We found the enzymes that occur in nature, which was not obvious, and both companies have patents on making those alkanes.

Others might claim that the link from light-activated microRNA biogenesis to the creation of enzymes, which link the metabolism of food to pheromones and the physiology of reproduction in species from microbes to humans, was not obvious.

But see: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Adenosine Triphosphate Definition (with my emphasis)

Adenosine triphosphate, also known as ATP, is a molecule that carries energy within cells. It is the main energy currency of the cell, and it is an end product of the processes of photophosphorylation (adding a phosphate group to a molecule using energy from light), cellular respiration, and fermentation. All living things use ATP. In addition to being used as an energy source, it is also used in signal transduction pathways for cell communication and is incorporated into deoxyribonucleic acid (DNA) during DNA synthesis.

The light-activated creation of ATP links microRNA biogenesis from biophysically constrained viral latency to all biodiversity on Earth via the physiology of plants, which links the pheromone-controlled physiology of reproduction in bacteria to the pheromone-controlled physiology of reproduction in humans. That fact was obvious to me and to Bruce McEwen when I spoke with him in the early 1990s.  I did not patent the human pheromones androstenol and androsterone because I respected the fact that others were not interested in research because they expected to deliver a billion dollar baby to an unsuspecting population of biologically uninformed science idiots. It takes someone special to attempt to do that, and someone who doesn’t care how much unnecessary suffering or premature death is caused while people wait.

See also: Increased growth rate and productivity following stable depletion of miR-7 in a mAb producing CHO cell line causes an increase in proteins associated with the Akt pathway and ribosome biogenesis

The facts about light energy-dependent ribosome biogenesis were also obvious to all serious scientists.

See for comparison: Lipid Encapsulation of Self Replicating Ribozymes

The evolution of a successful RNA polymerase ribozyme is a lofty goal.

Reaching that goal was importance to those who tout abiogenesis and mutation-driven evolution. I have dismissed the goal in the context of energy-dependent microRNA-mediated ribosome biogenesis. Does anyone think the goal (i.e., the evolution of a RNA polymerase ribozyme) is attainable in the context of anything known to any serious scientist under the sun?

If so, see for comparison: Eclipse with my emphasis

All that you touch
And all that you see
All that you taste
All you feel
And all that you love
And all that you hate
All you distrust
All you save
And all that you give
And all that you deal
And all that you buy
Beg, borrow or steal
And all you create
And all you destroy
And all that you do
And all that you say
And all that you eat
And everyone you meet
And all that you slight
And everyone you fight
And all that is now
And all that is gone
And all that’s to come
And everything under the sun is in tune
But the sun is eclipsed by the moon

See the attempt by Andrew Jones, who believes in abiogenesis to slight my 2013 published work: Nutrient-dependent/pheromone-controlled adaptive evolution: a model in his Criticisms of the nutrient-dependent pheromone-controlled evolutionary model and the journal editor’s ecliptic response.

Editor’s note

The 2013 review article by James Vaughn Kohl published in Socioaffective Neuroscience & Psychology and criticized in the above Letter to the Editor was subjected to standard peer review and the revised version was accepted by me after it had been accepted by both reviewers.

See also: An ancient relative of humans shows a surprisingly modern trait

…in most ways, this child’s dental development was very similar to what you would find in a child today.

The nonsense about the fossil record was destroyed by facts about the virus-driven degradation of messenger RNA, which link changes in modern humans to the descent of primate populations that are still considered to be our ancient relatives who mutated and became us.

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.

Positive selection for food energy-dependent pheromone-controlled viral latency can be viewed in the context of every report on microRNAs at the time the report is published.

See for example, from 1/16/19 miR-193b represses influenza A virus infection by inhibiting Wnt/beta-catenin signaling

Re: influenza A virus (IAV)

…our findings suggest that miR-193b represses IAV infection by inhibiting Wnt/beta-catenin signaling.

Repression of IAV is obviously RNA-mediated in the context of one food energy-dependent amino acid substitution in human populations that protects them from the virus-driven degradation of messenger RNA that is caused by amino acid substitutions in the IAV.

See: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

Editor’s summary: Five antigenic sites in the virus surface hemagglutinin protein, which together comprise 131 amino acid positions, are thought to determine the full scope of antigenic drift of influenza A virus. Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions. These single substitutions substantially skew the way the immune system “sees” the virus. All substitutions of importance are located next to the receptor-binding site in the hemagglutinin. Because there are few positions of importance for antigenic drift, there are strict biophysical limitations to the substitutions at these positions, which restricts the number of new antigenic drift variants at any point in time. Thus, the evolution of influenza virus may be more predictable than previously thought.

The claim that the influenza virus evolves must be placed into the context of the hecatombic evolution of all pathology because influenza pathogenesis is determined in part by the host response and microRNAs such as miR-1-1 and miR-133a-2  are encoded at two paralogous loci. They reportedly downregulate and display tumor-suppressive functions in various human cancers, which links miR-193b from ecological adaptations to IAV to cancer prevention and the prevention of all pathology.

Author: James Kohl

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