…follow-up studies may be needed for GWAS to most successfully guide biomedical research toward the molecular mechanisms underlying complex human disease.
Attempts to link GWAS to the molecular mechanisms underlying complex human disease are useless and worthless.
PsychENCODE also has a huge problem of consistency. Schizophrenia, autism, and bipolar disorders have been studied previously by GWAS—another pseudoscientific obscenity.
On December 21, 2018 Ryan Gutenkunst announced that his R01 proposal “Joint inferences of natural selection between sites and populations” had been funded.
I was surprised to learn that more funding was provided for inferences because all serious scientists know that natural selection for energy-dependent codon optimality links microRNAs to biophysically constrained viral latency and all biodiversity via the physiology of reproduction and RNA-mediated DNA repair.
Serious scientists have no use for the inferences of biologically uninformed theorists.
See the slides linked to the inferences via GWAS
See for comparison this presentation from the 2017 Labroots virtual conference on Precision Medicine:
EDAR V370A allele frequency links the mouse to human model of cell type differentiation in North and East Asian and New World populations via a bout of positive selection for food energy and the pheromone-controlled physiology of reproduction.
Follow-up studies are required to link other examples of allele frequency to biophysically constrained viral latency and healthy longevity in the context of what is known to all serious scientists about cell type differentiation in all living genera. Cell type differentiation is energy-dependent and the energy protects all cell types in all individuals of all species from the virus-driven degradation of messenger RNA, which has been linked from mutations to all pathology.