The tipping point (revisited): 77,000 publications

Summary: There were 19,000 fewer published works 19 months ago, but all of them linked light-activated microRNA biogenesis from viral latency to all biodiversity via Darwin’s “conditions of life” and the physiology of reproduction.

See: MicroRNA  Items: 1 to 20 of 77038

See for an example of how microRNA biogenesis has been linked to the regulation of protein folding chemistry and biophysically constrained cell biology: Intronic miRNA mediated gene expression regulation controls protein crowding inside the cell (Sep 3, 2018)

See for comparison:  Schrödinger at 75 – The Future of Biology – September 2018

Day 2 ended on Sep 6, 2018. Pseudoscientists and other theorists who presented failed to link light-activated microRNA biogenesis in cyanobacteria from from the production of oxygen by bacteria and the creation of uranium isotopes to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

For a historical perspective on their overwhelming displays of human idiocy, see Food energy and Feedback loops link odor and pheromone signaling with reproduction (2005)

…approximately 800 GnRH neurons communicate with approximately 50,000 neurons in 53 functionally diverse brain areas, with some connections exhibiting sexual dimorphism. These studies reveal a complex interplay between reproduction and other functions in which GnRH neurons appear to integrate information from multiple sources and modulate a variety of brain functions.

See also: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (Apr 18, 2018)

In my model, the feedback loops are energy-dependent and the energy comes from the sun. For instance, the anti-entropic virucidal effect of ultraviolet light and all other frequencies of energy-dependent signal transmission of information are essential links from microRNA biogenesis in unicellular algae to microRNA biogenesis in plants and to microRNA biogenesis in mammals.

For comparison, on Sep 6, 2018 Michael Rosbash claimed that circadian rhythms arose multiple time in evolution. Supposedly, the oldest clock is found cyanobacteria that oxygenate the atmosphere. After George Church et al., patented naturally occurring RNA interference, he told others the facts about light-activated carbon fixation in bacteria the produce uranium ores and the bacteria that produce oxygen.

The theft of quantized energy by cyanophages has since been linked to all pathology. See: Church Speaks

The cyanobacteria fix [carbon via] light as well or better than land plants. Under ideal circumstances, they can be maybe seven to ten times more productive per photon.

See also: Energy limitation of cyanophage development: implications for marine carbon cycling is the link from the virus-mediated hecatombic evolution of pathology in plants to humans.

See for comparison: Gene Expression Patterns during Light and Dark Infection of Prochlorococcus by Cyanophage

Light-tracking in Brugmansia is the link across kingdoms from soil bacteria to primates.

For example, the immature plant (1) tracks the light in the context of microRNA biogenesis and the mature scent-producing plant (2) stands straight up despite the added weight of the flower.


Facts about how light-activated microRNA biogenesis in Brugmansia biophysically constrains viral latency refute every aspect of neo-Darwinian pseudoscientific nonsense and Big Bang cosmology.

A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation

…plants alter microRNA (miRNA) biogenesis in response to light transition.

The extension to humans from biophysically constrained viral latency in plants was published as: Feedback-mediated signal conversion promotes viral fitness (2018)

…these results identify a regulatory mechanism enabling herpesviruses to sustain expression despite transient activation signals—akin to early electronic transistors—and expose a potential target for therapeutic intervention.


How biological systems robustly sustain differentiated states is under active study. Here, we find that human cytomegalovirus, a herpesvirus that is a major cause of birth defects, encodes a transcriptional positive-feedback loop that temporally extends transient activation signals carried in the incoming viral particle to sustain the viral lytic expression cycle. Attenuation of this feedback loop severely impacts virus fitness, suggesting a new antiviral target that may extend to other herpesviruses.

Reported as: Scientists find a new way to attack herpesviruses

Our findings uncover a circuit encoded by the virus that controls its fate and indicate that such circuits may be quite common in viruses.

The circuit is energy-dependent and the quantized energy in food biophysically constrains the virus-driven degradation of messenger RNA that links mutations from herpes viruses and other viruses to all pathology.

See for comparison: Study confirms truth behind ‘Darwin’s moth’

Remarkably, no previous study has quantified the camouflage of peppered moths, or related this to survival against predators in controlled experiments.

Now, after publication of facts about how Olfaction Warps Visual Time Perception, bird watchers and butterfly collectors want you to continue to believe that Darwin’s conditions of food energy-dependent pheromone-controlled reproduction in species from microbes to mammals can be placed back into the context of natural selection for beneficial mutations.

Pseudoscientists are not going to accept the fact that Wen Zhou’s group linked the physiology of pheromone-controlled reproduction in soil bacteria to our visual perception of mass and energy in the context of the space-time continuum.

See: Odors Alter Subjective Time Experience May 15, 2017

The sense of smell is like a time machine that links our experiences from the past to our behaviors throughout life.

And see: Olfactory-Visual Sensory Integration Twists Time Perception July 22, 2017

See also: February 15, 2017 (less than 19 months ago there were 58,000 published works that linked light-activated microRNA biogenesis from viral latency to all biodiversity)

Author: James Kohl

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