The tipping point (revisited): 100K (1)

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microrna coronavirus 1-27

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Change the discussion from coronaviruses to one of two or three strains of Covid-19, and you may never go home again after your quarantine.

See for comparison:

MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20

MicroRNAs organize intrinsic variation into stem cell states 3/5/20

…naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology.

For comparison, see: Cytokine release syndrome

A correspondent asked: Is this what happens with Covid-19?

See: COVID-19: consider cytokine storm syndromes and immunosuppression 3/16/20

As of March 12, 2020, coronavirus disease 2019 (COVID-19) has been confirmed in 125 048 people worldwide, carrying a mortality of approximately 3·7%,¹ compared with a mortality rate of less than 1% from influenza.

Twelve experts do not agree with that assessment. See: 12 Experts Questioning the Coronavirus Panic. You may not need to understand the complexities of the cytokine storm if you consider what these 12 experts are saying about how the panic was orchestrated.

Dr Sucharit Bhakdi

All these measures are leading to self-destruction and collective suicide based on nothing but a spook.

Dr Wolfgang Wodarg

…what is missing right now is a rational way of looking at things.

Dr Joel Kettner

In Hubei, in the province of Hubei, where there has been the most cases and deaths by far, the actual number of cases reported is 1 per 1000 people and the actual rate of deaths reported is 1 per 20,000. So maybe that would help to put things into perspective.

Dr John Ioannidis

If we had not known about a new virus out there, and had not checked individuals with PCR tests, the number of total deaths due to “influenza-like illness” would not seem unusual this year. At most, we might have casually noted that flu this season seems to be a bit worse than average.

Dr Yoram Lass

At that time there was no Facebook or there maybe was but it was still in its infancy. The coronavirus, in contrast, is a virus with public relations.
Whoever thinks that governments end viruses is wrong.

Dr Pietro Vernazza

If we close the schools, we will prevent the children from quickly becoming immune.
We should better integrate the scientific facts into the political decisions.

Frank Ulrich Montgomery

Italy has imposed a lockdown and has the opposite effect. They quickly reached their capacity limits, but did not slow down the virus spread within the lockdown.

Prof. Hendrik Streeck

Since he was infected, he naturally appears in the Covid 19 statistics. But the question is whether he would not have died anyway, even without Sars-2.

Dr Yanis Roussel et. al.

…the percentage of asymptomatic carriers is equal to or even higher than the percentage of symptomatic patients. The same data for SARS-CoV-2 may soon be available, which will further reduce the relative risk associated with this specific pathology.

Dr. David Katz

The unemployment, impoverishment and despair likely to result will be public health scourges of the first order.

Michael T. Osterholm

[T]he best alternative will probably entail letting those at low risk for serious disease continue to work, keep business and manufacturing operating, and “run” society, while at the same time advising higher-risk individuals to protect themselves through physical distancing and ramping up our health-care capacity as aggressively as possible. With this battle plan, we could gradually build up immunity without destroying the financial structure on which our lives are based.

Dr Peter Goetzsche

Should it turn out that the epidemic wanes before long, there will be a queue of people wanting to take credit for this. And we can be damned sure draconian measures will be applied again next time. But remember the joke about tigers. “Why do you blow the horn?” “To keep the tigers away.” “But there are no tigers here.” “There you see!”

It seems likely that all 12 of these experts would support the logic behind the claim that: “The Netherlands Is Letting People Get Sick to Beat Coronavirus”

Herd immunity is food energy-dependent and biophysically constrained by pheromones. The Dutch whose ancestors survived the “hunger winter” are more likely to survive the orchestrated coronavirus Covid-19 crisis because someone understands the facts about how food odors and pheromones biophysically constrain viral latency across kingdoms. See [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)]. (1994)

The fact that light-activated microRNA biogenesis has been linked to prevention of the virus-induced cytokine storm was reported as:

MicroRNA-302a suppresses influenza A virus-stimulated interferon regulatory factor-5 expression and cytokine storm induction 10/18/17

…we observed that IRF-5 is a direct target of miR-302a, which down-regulated IRF-5 expression by binding its 3′-UTR. Moreover, IAV increased IRF-5 expression by down-regulating miR-302a expression. Interestingly, miR-302a inhibited IAV replication. In IAV-infected patients, miR-302a expression was down-regulated, whereas IRF-5 expression was up-regulated. Taken together, our work uncovers and defines a signaling pathway implicated in an IAV-induced cytokine storm.

The fact that food odors and pheromones biophysically constrain the genetic processes that prevent the virus-driven cytokine storm was placed into the context of:

Feedback loops link odor and pheromone signaling with reproduction 11/18/05

This is how far back you must go to learn how to end the current coronavirus crisis and prevent the next one.

 

Start with God’s Creation of sunlight and water. Link it from oxidative phosphorylation to the stability of supercoiled DNA via RNA interference.

Find out who is pretending not to know about this and why they want the panic to continue. Start by linking light-activated microRNA biogenesis to biophysically constrained viral latency across kingdoms. Then follow the money!

Alternatively, you could let Diego V. Bohórquez et al. explain how the composition of the nutrient-dependent pheromone-controlled gut microbiome links social odors to biophysically constrained coronavirus / Covid19 pathology via “herd immunity” across kingdoms.

See: A gut-brain neural circuit for nutrient sensory transduction 9/21/18

See also: The tipping point (revisited): 100K (2)