The memory of oxygen (1)

Alternative splicing vs mutation-driven evolution

James V. Kohl @microRNApro 10/22/19

How many times have you claimed that alternative splicings of RNA do not make changes to DNA during the time that I have linked energy-dependent changes from angstroms to ecosystems in all living genera? Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

Andrew Jones @aj170664 Replying to @microRNApro 10/22/19

Many, many times. Splicing happens to RNA AFTER it has been transcribed from the DNA. It has nothing to do with DNA. Why you continue to insist it does is astounding. It’s an incredible mistake you’re making about basic biology.

See: Structural diversity of supercoiled DNA 10/12/15

By regulating access to the genetic code, DNA supercoiling strongly affects DNA metabolism. Despite its importance, however, much about supercoiled DNA (positively supercoiled DNA, in particular) remains unknown. Here we use electron cryo-tomography together with biochemical analyses to investigate structures of individual purified DNA minicircle topoisomers with defined degrees of supercoiling. Our results reveal that each topoisomer, negative or positive, adopts a unique and surprisingly wide distribution of three-dimensional conformations. Moreover, we uncover striking differences in how the topoisomers handle torsional stress. As negative supercoiling increases, bases are increasingly exposed. Beyond a sharp supercoiling threshold, we also detect exposed bases in positively supercoiled DNA. Molecular dynamics simulations independently confirm the conformational heterogeneity and provide atomistic insight into the flexibility of supercoiled DNA. Our integrated approach reveals the three-dimensional structures of DNA that are essential for its function.

In my model, God’s Creation of energy as information links His Creation of sunlight and water from light-activated microRNA biogenesis to the oxygen-dependent ATP-dependent, enzyme-dependent creation of RNA, which biophysically constrains microRNA-mediated alternative splicings of messenger RNA. The alternative splicings are essential to the biophysically constrained functional structure of supercoiled DNA.

For comparison, you have stated your ridiculous belief that abiogenesis led to the evolution of self-replicating ribozymes that you linked to DNA topology.

Lipid Encapsulation of Self-Replicating Ribozymes and Dna Topology

I have placed your moronic pseudoscientific nonsense into the following context:

The light-activated assembly of the microRNA-RNA-peptide nanocomplex links natural information processing in bacteria from oxygen-dependent enzyme-dependent fixation of RNA-mediated amino acid substitutions to biophysically constrained viral latency via the physiology of reproduction. The physiology of pheromone-controlled reproduction in bacteria links transgenerational epigenetic inheritance to all morphological and behavioral diversity on Earth via this example of energy-dependent biophysically constrained chemogenetic kinetics.

An example of support for my claims was published as Memory of recent oxygen experience switches pheromone valence in Caenorhabditis elegans 4/3/17

A sustained change in the activity of O(2)-sensing neurons reprograms the properties of their postsynaptic partners, the RMG hub interneurons. RMG is gap-junctionally coupled to the ASK and ADL pheromone sensors that respectively drive pheromone attraction and repulsion. Prior O(2) experience has opposite effects on the pheromone responsiveness of these neurons. These circuit changes provide a physiological correlate of altered pheromone valence. Our results suggest C. elegans stores a memory of recent O(2) experience in the RMG circuit and illustrate how a circuit is flexibly sculpted to guide behavioral decisions in a context-dependent manner.

Simply put, a change in the diet of Caenorhabditis elegans is all that is required for the context-dependent pheromone-controlled System-wide Rewiring [that] Underlies Behavioral Differences in Predatory and Bacterial-Feeding Nematodes 1/17/13

Reported as: The neurobiological consequence of predating or grazing

1) “By means of their shape and position each of the 20 neurons in Pristionchus pacificus could be correlated to an exact equivalent in Caenorhabditis elegans” explains the scientist. “This is all the more astonishing as the evolutionary distance between the two worm species is over 200 million years and they differ markedly in feeding behaviour and in the anatomy of their mouth parts.” While C. elegans feeds exclusively on bacteria, P. pacificus is able to switch its behaviour to prey on other worms if bacterial food gets scarce. information flow correlates perfectly with the predatory feeding behaviour of the worm.

2) “The patterns of synaptic connections perfectly mirror the fundamental differences in the feeding behaviours of P. pacificus and C. elegans”, Ralf Sommer concludes. A clear-cut result like that was not what he had necessarily expected. Previous studies in much simpler neural circuits – as in the marine snail Aplysia – had indicated that changes in behaviour do not have to coincide with changes in number and location of synapses. Differences in physiological properties of neurons or in their modulation by neurotransmitters can be sufficient to effect behavioural changes.

The claim that the “evolutionary distance between the two worm species is over 200 million years” is based on the moronic pseudoscientific nonsense touted by many neo-Darwinian theorists. They ignore the fact that Darwin’s “conditions of life” were clearly placed before his theory of ‘evolved’ differences. Theorists tend to dismiss the nutrient-dependent pheromone-controlled “conditions of life” when they tout their ridiculous claims about the unconstrained evolution of speciation. For example, the mutations are not constrained, and that’s how they link natural selection to evolution.  

For comparison, sympatric speciation in nematodes is exemplified in the sympatric speciation of all species on Earth. See: Tracking niche variation over millennial timescales in sympatric killer whale lineages 10/7/13 

1) Ecological variation is the raw material by which natural selection can drive evolutionary divergence [1–4].

2) The differences in amino acid composition among different tissues can lead to large differences in trophic discrimination [38].

The energy-dependent fixation of amino acid composition among different tissues is biophysically constrained by the pheromone-controlled physiology of reproduction in species from microbes to humans.

See also: peptide pheromone Items: 1 – 11884

Or pay to see: Sean Parker, billionaire and philanthropist, gets an immunotherapy company off the ground. Alternatively see my comments on Facebook:

James Kohl He will lose millions now that the patented cure for all cancers has been issued. Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest 12/25/18  Proof of concept

James Kohl Do you know anything about how the light-activated assembly of the microRNA-RNA-peptide nanocomplex biophysically constrains the virus-driven degradation of messenger RNA that links mutations to all pathology, not just all cancers? That was a rhetorical question.

James Kohl The proof of concept drives theorists crazy.

James Kohl They have linked “Memory of recent oxygen experience switches pheromone valence in Caenorhabditis elegans” from the food energy-dependent pheromone-controlled assembly of new peptides to biophysically constrained viral latency and healthy longevity via the cure for cancer. For the patented cure for all other pathology, see: RNA-Guided Human Genome Engineering

See also:

Impaired proteostasis in response to early life stress in the adult and aged hippocampus 10/23/19

Levels of phospho-Tau were found to be decreased in the aged male HIPP, with the enzyme BACE showing decreased levels in ELS males.

See also: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Evolutionists Cannot Account for the Origin of… (free book)

Theorists can’t link alternative splicings from the light-activated assembly of the miRNA-RNA-peptide nanocomplex to the Creation of the sense of smell in bacteria to biophysically constrained viral latency.

That is how biologically uninformed science idiots have helped to create the examples of dystopia manifested during the 2019 annual meeting of the Society for Neuroscience, where people who cannot link what organisms eat during childhood from the physiology of reproduction to all biodiversity scurry about like insects.

But see: Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene (1991)

Feedback loops link odor and pheromone signaling with reproduction (2005)

and Olfaction Warps Visual Time Perception (2017)

The fact that olfaction warps time perception is an essential consideration for those who are working towards the cure for Alzheimer’s disease, which is obviously microRNA-mediated in the context of peptide pheromones that were linked to neurogenesis  in Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis

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