Sunday Book Review
Missing Links
‘Neanderthal Man,’ by Svante Paabo
By CARL ZIMMER
Excerpt: “He argues that the Neanderthal genome can serve as a counterpoint to our own. It enables Paabo and his colleagues to draw up a list of mutations that our ancestors acquired after they split from Neanderthals.”
My comment: In Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan, he argues — with co-authors — that differences in methylation “…will help to uncover the epigenetic basis for phenotypic differences between present-day and archaic humans…” Difference in methylation are nutrient-dependent. That means the missing link of human diversity is the olfactory/pheromonal link from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man. That missing link between nutrient-dependent natural genetic engineering and pheromone-controlled species diversity eliminates evolution attributed to mutations, and makes ecological variation responsible for ecological adaptations.
See also: The end of human evolution: Ecological adaptations
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.