Tag: supercoiled DNA
The memory of oxygen (1)
James V. Kohl @microRNApro 10/22/19 How many times have you claimed that alternative splicings of RNA do not make changes to DNA during the time…
Patented Creation vs Evolution of Disease (6)
The Nobel Prize in Physics 2018 was awarded to researchers whose inventions revolutionized laser physics. Femtosecond blasts of ultraviolet light have been linked from RNA-mediated…
Light-activated chemogenetic kinetics (1)
Hydrophobic catalysis and a potential biological role of DNA unstacking induced by environment effects 8/14/19 …hydrophobic interactions may have catalytic roles also in other biological…
Nutrient-dependent Pheromone-controlled cures (1)
See first: Lewis Thomas (revisited): 90K (7) The existence of light-activated inter-organism systems of genetic regulation has been relatively ignored for ~25 more years, which…
Sunlight, hydrophobicity and biodiversity (3)
Ed Yong sneaks up from behind with A New Clue to How Life Originated 8/12/19 A long-standing mystery about early cells has a solution—and it’s…
Sunlight, hydrophobicity and biodiversity (1)
A five-coordinate Mn(iv) intermediate in biological water oxidation: spectroscopic signature and a pivot mechanism for water binding 11/17/15 …a multi-step process that involves the redox-active…
The tipping point (revisited): 89K (4)
MicroRNA Items: 1 to 88927 See also: Oral Sunscreen Provides All-Over Protection Exogenous sources of vitamin B3 (aka Niacinamide/Nicotinamide) and vitamin C link ingestion of…
The tipping point (revisited): 86,000 publications
“Darwin had a huge data set and no mechanism—where would he publish today? This is a problem!” — Arturo Casadevall Darwin’s light-activated “conditions of life” are…
Kohl and Francoeur at 25 (4)
Re: Pathological Pseudomonas aeruginosa vs beneficial Pseudomonas fluorescens Pattern recognition for ages 10+ Subatomic and Cytosis Summary: Changes in base pairs biophysically constrain viral latency….
DS Wilson’s view of biophysically constrained life (3)
A Different Kind of Theory of Everything (2/19/19) 1) In 1964, during a lecture at Cornell University, the physicist Richard Feynman articulated a profound mystery…
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.