reward

Biophysically constrained cell type differentiation

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Intrinsic limits to gene regulation by global crosstalk Excerpt: A paradigmatic example is that of the aminoacyl transfer RNA synthetase1, which uses kinetic proofreading2 to load appropriate amino acids onto matching tRNAs. This and other examples—including DNA replication, ligand sensing3, protein–protein interactions4,5,6,7,8,9, recognition events in the immune system10,11 and molecular self-assembly12—indicate that biology places a … Biophysically constrained cell type differentiation

Where is the love?

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If you want to know where love is, you can find out by following the path from your nose to the brain via the epigenetic effects of food odors and pheromones on hormone-secreting nerve cells, not one that somehow links pictures to love and sexual desire. There’s no model for that!