Posted in Adaptations base editing biophotonics Chemogenetics Cytosis Diseases & Disorders Ecology

The tipping point (revisited): 90K (1)

Role of miRNAs in tumor and endothelial cell interactions during tumor progression 8/3/19 …during dissemination, tumor cells have to escape from the primary tumor mass,…

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Posted in Adaptations Diseases & Disorders Ecology

The eternal significance of microRNA biogenesis (3)

Summary: One year after my series on The eternal significance of microRNAs was completed, I tweeted the question: How are mutations linked to evolution? Decoding…

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Posted in Autophagy Common Scents Thoughts What's in the News

Light-activated ecological adaptation (2)

Theorists who have not started with light-activated microRNA biogenesis and the creation of the sense of smell are scared. See: Double-edged effects of noncoding RNAs…

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Posted in Adaptations Diseases & Disorders Ecology

The tipping point (revisited): 81,000 publications (5)

The impact of genome-wide association studies [GWAS] on biomedical research publications …follow-up studies may be needed for GWAS to most successfully guide biomedical research toward…

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Posted in Adaptations Diseases & Disorders Ecology MicroRNA biogenesis

Light and life at base pair resolution (4)

MicroRNA from Small Oligunucletoides to Giant Players of Biological Processes and Diseases (2019) My summary: Bioinformatic data should only be used to set up experiments…

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Posted in Adaptations Alternative Splicings base editing Cytosis Diseases & Disorders Ecology Human Pheromones Model Organisms

Hide and seek with science facts (2)

Largest Study of CRISPR-Cas9 Mutations Creates Prediction Tool for Gene Editing 11/28/18 (Lab Manager) CRISPR-Cas9 is an extremely important system for introducing mutations into DNA…

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Posted in Adaptations Autophagy Cytosis Diseases & Disorders MicroRNA biogenesis Model Organisms Variations

Creation of an enzyme that kills theories (3)

Summary: Yesterday, the pseudoscientific nonsense touted by biologically uninformed population geneticists was placed into the context of the #ASHG18 Presidential address. Previously: Light-activated microRNA biogenesis…

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Posted in Scientific Discoveries What's in the News

More than speculation: adaptive evolution in species from microbes to man

I’ve dismissed evolutionary theory that involves random mutations, and used the epigenetic effects of olfactory/pheromonal input on OR variants, which provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans,

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