Tag: microRNA
Non-random vs random selection for receptor clonotypes
High frequency of shared clonotypes in human B cell receptor repertoires Reported as: Decoding the human immune system (2/13/19) The receptors randomly select and join…
Viral latency vs deadly paleoanthropology (2)
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target Re: “Virus infection reprogrammed host lipid metabolism” (with my emphasis) Within the major category of metabolism, there…
Energy-dependent thymic involution vs evolution (2)
Summary: The “initiator” RNA links the virus-driven degradation of messenger RNA from constraint-breaking mutations to all pathology via what is known about biophysically constrained viral…
10,000 reasons to believe in biophysical constraints (3)
See: The Darwin Code by Greg Bear Charles Darwin was wise enough not to pin down what he could not see or know, and so,…
Energy-dependent ‘futile cycles’ of autophagy
Quantized energy from virucidal sunlight protects the cell types of all living genera from the degradation of messenger RNA that links mutations to pathology. That…
microRNA targeting efficacy refutes ridiculous theories
The biochemical basis of microRNA targeting efficacy Hold on, this is waiting to be approved by BioRxiv. This highly significant somewhat cloaked advancement of a…
Constraints on mutational drift
mutations are extremely unlikely and they are also not likely to be adaptive
Epigenetic effects underlie sexual preferences IV
I include more information about the molecular mechanisms responsible for “…sex-specific regulation of miRNA levels that are known to influence sexually dimorphism of mRNA concentrations in the brains of mice” and in other species from microbes to man.
The hormone-miRNA axis, life span, and sexual orientation
Instead of simply offering more evolutionary theory, we detailed the link from the sensory environment to sexual orientation (e.g., the epigenetic effects of pheromones on the gonadotropin releasing hormone neuronal system).
MicroRNA binds messenger RNA: Adaptive Evolution
This model of systems biology represents the conservation of bottom-up organization and top-down activation and the required reciprocity that links genes to behavior and back.
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.