Posted in Adaptations Alternative Splicings Common Scents Thoughts Diseases & Disorders Ecology MicroRNA biogenesis Model Organisms RNA–Mediated Epigenetic Heredity

Non-random vs random selection for receptor clonotypes

High frequency of shared clonotypes in human B cell receptor repertoires Reported as: Decoding the human immune system (2/13/19) The receptors randomly select and join…

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Posted in Adaptations Autophagy Cytosis Diseases & Disorders Ecology MicroRNA biogenesis Scientific Discoveries Subatomic What's in the News

Viral latency vs deadly paleoanthropology (2)

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target Re: “Virus infection reprogrammed host lipid metabolism” (with my emphasis) Within the major category of metabolism, there…

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Posted in Autophagy base editing biophotonics Ecology Light Energy MicroRNA biogenesis RNA interference

Energy-dependent thymic involution vs evolution (2)

Summary: The “initiator” RNA links the virus-driven degradation of messenger RNA from constraint-breaking mutations to all pathology via what is known about biophysically constrained viral…

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Posted in Adaptations Autophagy biophotonics Cytosis Ecology MicroRNA biogenesis Model Organisms RNA-mediated epigenetic regulation of gene expression Subatomic

10,000 reasons to believe in biophysical constraints (3)

See: The Darwin Code by Greg Bear Charles Darwin was wise enough not to pin down what he could not see or know, and so,…

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Posted in Adaptations Autophagy Cytosis Subatomic

Energy-dependent ‘futile cycles’ of autophagy

Quantized energy from virucidal sunlight protects the cell types of all living genera from the degradation of messenger RNA that links mutations to pathology. That…

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Posted in Adaptations Alternative Splicings base editing Ecology MicroRNA biogenesis RNA-directed DNA methylation What's in the News

microRNA targeting efficacy refutes ridiculous theories

The biochemical basis of microRNA targeting efficacy Hold on, this is waiting to be approved by BioRxiv. This highly significant somewhat cloaked advancement of a…

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Posted in Scientific Discoveries

Constraints on mutational drift

mutations are extremely unlikely and they are also not likely to be adaptive

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Posted in Scientific Discoveries

Epigenetic effects underlie sexual preferences IV

I include more information about the molecular mechanisms responsible for “…sex-specific regulation of miRNA levels that are known to influence sexually dimorphism of mRNA concentrations in the brains of mice” and in other species from microbes to man.

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Posted in Common Scents Thoughts Scientific Discoveries What's in the News

The hormone-miRNA axis, life span, and sexual orientation

Instead of simply offering more evolutionary theory, we detailed the link from the sensory environment to sexual orientation (e.g., the epigenetic effects of pheromones on the gonadotropin releasing hormone neuronal system).

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Posted in Scientific Discoveries What's in the News

MicroRNA binds messenger RNA: Adaptive Evolution

This model of systems biology represents the conservation of bottom-up organization and top-down activation and the required reciprocity that links genes to behavior and back.

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