Jon Lieff

MicroRNAs biophysically constrain Virus-driven pathology (4)

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Passive-aggressive antagonist Jon Lieff is again attempting to sneak up from behind on FB via his 11/26/19 regurgitation of this report on Cell signalling breakthrough opens up new avenues for research 11/4/19 The study results were published as Strong anion exchange-mediated phosphoproteomics reveals extensive human non-canonical phosphorylation 8/21/19 The authors revealed that energy-dependent cell signaling … MicroRNAs biophysically constrain Virus-driven pathology (4)

Energy-dependent physical and biophysical constraints (2)

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Summary: The mind does not exist in nature. It is a manifestation of how ecological variation must be linked to the creation of food energy-dependent pheromone-controlled ecological adaptations. Energy-dependent physical and biophysical constraints (1) The energy-dependent de novo creation of all receptors is biophysically constrained. See: Channel opening and gating mechanism in AMPA-subtype glutamate receptors … Energy-dependent physical and biophysical constraints (2)

Autophagy and health or virus-driven pathology

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MiR-142-3p Overexpression Increases Chemo-Sensitivity of NSCLC by Inhibiting HMGB1-Mediated Autophagy Conclusion: HMGB1 is involved in major DNA repair pathways and regulates cell death and survival [27]. Xiao and coworkers have reported that miR-142-3p directly targets HMGB1 to inhibit NSCLC cell proliferation and induce cell apoptosis [18], but the underlying mechanisms have not been elaborated. Our … Autophagy and health or virus-driven pathology

Mitochondria do not adapt

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Mitochondria Help Cancers Grow Mitochondria adapt by producing cycles whereby electrons are removed from carbon at a greater rate as food is oxidized to make molecules for the cancers. Mitochondria do not ‘produce’ the ‘cycles’ that link ‘food’ from one carbon metabolism to healthy longevity. Mitochondria do not ‘adapt.’ The food enables thermodynamic cycles of … Mitochondria do not adapt

Energy-dependent oscillating gene networks organize life

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Nascent, innate, intrinsic, and biofunctional are among the “weasel words” used by theorists who ignore the fact that all life-sustaining energy comes from the sun via hydrogen-atom transfer in DNA base pairs in solution. See how Jon Lieff continues to misrepresent that fact, by placing everything known about RNA-mediated cell type differentiation back into the … Energy-dependent oscillating gene networks organize life

Chromatin: The structure of DNA

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Update on Inflammation and Degenerative Brain Disease Excerpt: While mapping connections of neurons has become the holy grail of current neuroscience, it is clear that communication of neurons with many other types cells is, also, vitally important to every aspect of brain function. My comment: Understanding dementia was placed into the context of understanding how … Chromatin: The structure of DNA

Energy-dependent RNA methylation (7)

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“…viral latency is responsible for life-long pathogenesis and mortality risk…” – Lieberman (2016) My comment: Energy-dependent RNA-mediated amino acid substitutions are responsible for life-long healthy longevity and decreased mortality risk. See for comparison: How cancer was created by evolution Excerpt 1) But even though it is evolutionary processes that have made cancer such a problem, … Energy-dependent RNA methylation (7)