See for comparison: 6mer seed toxicity in tumor suppressive microRNAs …during evolution most miRNAs evolved to avoid guanine at the 5′ end… but some tumor-suppressive…
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.
Autophagy.Pro RNA-Mediated Perfuming The Mind