Some Principles of Causal Analysis in Genetics (1936) Extract: high frequency radiation and particles of high velocity are very important components of the environment, causing heritable changes by a process called mutation. Even if we could conduct our experiments behind 30 metres of lead the fact that mutation has a temperature coefficient is enough to … A lighting requirement for life
Diet rich in methionine may promote memory loss Excerpt: “We are looking further into epigenetic factors like microRNA and other downstream genes that could be associated with memory loss.” See also: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (an invited review of nutritional epigenetic) Abstract excerpt: “This atoms to ecosystems model of ecological adaptations … MicroRNAs and memory
Imre Lakatos Excerpt: “A Lakatosian research programme[8] is based on a hard core of theoretical assumptions that cannot be abandoned or altered without abandoning the programme altogether. More modest and specific theories that are formulated in order to explain evidence that threatens the ‘hard core’ are termed auxiliary hypotheses. Auxiliary hypotheses are considered expendable by … From Hydra to humans vs a Lakatosian research program
On the Importance of Being a Methodological Naturalist Posted on November 5, 2014 by David Sloan Wilson Excerpt: “…consider the flying spaghetti monster, a deity invented to poke fun at religion. It is ridiculous, but is there any way to prove that it doesn’t exist?” Conclusion: “If religious believers abandon methodological naturalism, then they are forced … Nothing new under the sun, except pseudoscientific nonsense
Speaking of Science November 2014’s selection of notable quotes By The Scientist Staff | November 1, 2014 My comment: The quotes are scattered from across disciplines, but can be linked to what is known about conserved molecular mechanisms of biologically-based cause and effect that, in context, make sense of them. 1) Cell type differentiation occurs … Making sense of quotes scattered across disciplines
“Shown is the location of the conserved regions encoding for the N-terminal chromo domain and the C-terminal MYST functional domain. An arrow denotes the position site of amino acid substitution E431Q.” Microarray Analysis Uncovers a Role for Tip60 in Nervous System Function and General Metabolism My comment: The article links a nutrient-dependent amino acid substitution … Metabolism, fixation, health or neurodegerative disorder
Part 1 From its most basic expression in grazing and predatory nematodes with differences in morphological and behavioral phenotypes, neurogenic niche construction is nutrient-dependent and pheromone-controlled. One of these two worms has teeth. It also recognizes self vs other differences and eats other worms. “The patterns of synaptic connections perfectly mirror the fundamental differences in … Ecological variation and niche construction: 1, 2, 3
Epigenetics of Trained Innate Immunity: Documenting the epigenetic landscape of human innate immune cells reveals pathways essential for training macrophages. By Ruth Williams | September 25, 2014 [open access] Excerpt: “…they then analyzed genome-wide distributions of four epigenetic indicators of gene activity: DNAse hypersensitivity and three different histone modifications—trimethylation of histone H3 at lysine 4, … Epigenetically-effected metabolic shifts and ecological adaptations
Diana Maria Petrosanu also asked: “who was the author of the article that had stolen your ideas?“ I cannot recall claiming that anyone had stolen our ideas or my ideas. See: Behavior: The first response is RNA-mediated not genetically-determined. In subsequent published works, I extended what we detailed about the molecular epigenetics of sex differences … Behavior (2): All responses are RNA-mediated not genetically-determined
In his posts that I have linked below, Jay R. Feierman takes us from random mutations on which natural selection acts to natural selection for phenotypes and changes in the brain that lead to increased reproductive success. According to him, the change in the brain can be called an adaptation. In my model, ecological variation … Jay R. Feierman
