Posted in Adaptations Alternative Splicings Autophagy base editing biophotonics Chemogenetics Cytosis Diseases & Disorders Ecology Subatomic What's in the News

The tipping point (revisited): 93K (1)

Historical perspective: Targeted photoredox catalysis in cancer cells 9/23/19 On light irradiation, complex 1 induces NADH depletion, intracellular redox imbalance and immunogenic apoptotic cancer cell…

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Endogenous substrates
Posted in Adaptations Alternative Splicings Autophagy base editing biophotonics Chemogenetics Cytosis Diseases & Disorders Ecology Human Pheromones

Patented Creation vs Evolution of Disease (8)

The 2019 Nobel Prize for Physiology or Medicine for their discoveries of how cells sense and adapt to oxygen availability was shared by Gregg L….

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Posted in Adaptations base editing biophotonics Chemogenetics Cytosis Diseases & Disorders Ecology Light Energy MicroRNA biogenesis RNA interference RNA-mediated epigenetic regulation of gene expression

Patented Creation vs Evolution of Disease (2)

See: Patented Creation vs Evolution of Disease (1) 10/2/19 The light-activated assembly of the microRNA-RNA-peptide nanocomplex (aka the polycomb repressive complex) has been linked to…

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Posted in Adaptations biophotonics Diseases & Disorders Ecology MicroRNA biogenesis RNA interference

Brokered regulatory leverage: Breaking Bad (1)

Summary: Breaking Bad. 2008TV-MA 5 Seasons Crime TV Shows. A high school chemistry teacher dying of cancer teams with a former student to secure his…

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Posted in Adaptations biophotonics Chemogenetics Cytosis Diseases & Disorders Ecology Model Organisms RNA interference RNA-mediated epigenetic regulation of gene expression

Sunlight, hydrophobicity and biodiversity (3)

Ed Yong sneaks up from behind with A New Clue to How Life Originated 8/12/19 A long-standing mystery about early cells has a solution—and it’s…

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Posted in Adaptations base editing biophotonics Chemogenetics Cytosis Diseases & Disorders Ecology

The tipping point (revisited): 90K (1)

Role of miRNAs in tumor and endothelial cell interactions during tumor progression 8/3/19 …during dissemination, tumor cells have to escape from the primary tumor mass,…

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Posted in Adaptations base editing Diseases & Disorders Ecology Light Energy MicroRNA biogenesis RNA interference Variations

Relatable not debatable (1)

Earlier today, I spoke with Charles. His superior use of analogies extended from food energy as information: “It’s like extra cheese on pizza,” to successful…

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Posted in Adaptations base editing biophotonics Cytosis Diseases & Disorders Ecology Subatomic

The tipping point (revisited): Big Data (2)

The tipping point (revisited): Big Data (1) Forthcoming: Range: Why Generalists Triumph in a Specialized World See: The Peculiar Blindness of Experts Some made authoritative…

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Posted in Adaptations biophotonics Cytosis Diseases & Disorders Ecology RNA interference

Gamification of creationism (1)

Thanks to David Sloan Wilson for inspiring me to write this series. See my book review:  He places neo-Darwinian evolution back into the context of…

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Posted in Adaptations Autophagy Diseases & Disorders Ecology RNA interference RNA–Mediated Epigenetic Heredity

Biophysical constraints on RNA synthesis (1)

Includes: Constraints on amino acid substitutions in peptides Constraints on nanocomplexes Constraints on systems complexity Summary: The role that energy-dependent changes in the microRNA/messenger RNA…

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