Posted in Adaptations Autophagy base editing biophotonics Chemogenetics Cytosis Diseases & Disorders Ecology Human Pheromones Model Organisms

FDA’s ignorance: From roots to shoots (1)

See: CDC’s ignorance: From roots to shoots (1) Facts about food safety linked vitamin C and vitamin D3 to fixation of amino acid substitutions and…

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Posted in Adaptations Alternative Splicings Diseases & Disorders Ecology Human Pheromones microRNA editing

microRNA-mediated sex differences (1)

For recent support of our claims from 23 years ago, see: Sexual dimorphism of miRNA signatures in feto-placental endothelial cells is associated with altered barrier…

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Posted in Adaptations Autophagy base editing biophotonics Chemogenetics Cytosis Diseases & Disorders Ecology

MicroRNAs biophysically constrain Virus-driven pathology (6)

Summary: The fact that autophagy biophysically constrains energy-dependent viral latency and healthy longevity has gone missing from the pseudoscientific nonsense touted by neo-Darwinian theorists, Big…

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Posted in Adaptations Alternative Splicings Autophagy base editing Chemogenetics Cytosis Diseases & Disorders Ecology Human Brain

MicroRNAs on Veteran’s Day 2019

Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model 10/10/19 …the nasal-to-brain pathway is efficient and operable…

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Posted in Adaptations Alternative Splicings Autophagy base editing biophotonics Chemogenetics Diseases & Disorders Ecology Human Pheromones Model Organisms Nutrigenomics Pharmacogenomics

2020 National Vaccine Plan (1)

All polymaths probably know that the claims from Unified rational protein engineering with sequence-based deep representation learning 10/21/19 attest to facts about why vaccines are…

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Posted in Adaptations Alternative Splicings Autophagy base editing Chemogenetics Cytosis Diseases & Disorders Ecology

#SFN2019 to 2012: Hiding the facts (7)

Ariel Bazzini linked natural selection for food energy-dependent pheromone-controlled codon optimality to biophysically constrained viral latency via RNA-mediated fixation of amino acid substitutions and sympatric…

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Posted in Adaptations Alternative Splicings Autophagy base editing biophotonics Chemogenetics Diseases & Disorders Ecology

Patented Creation vs Evolution of Disease (6)

The Nobel Prize in Physics 2018 was awarded to researchers whose inventions revolutionized laser physics. Femtosecond blasts of ultraviolet light have been linked from RNA-mediated…

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Posted in Adaptations Alternative Splicings Autophagy base editing Chemogenetics Cytosis Diseases & Disorders Ecology microRNA editing RNA interference Subatomic

Chemogenetic kinetics (7): DHA vs consensus (4)

Mammalian Y RNAs are modified at discrete guanosine residues with N-glycans 9/30/19  …mammalian cells use RNA as a third scaffold for glycosylation in the secretory…

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Posted in Adaptations Alternative Splicings Autophagy Chemogenetics Cytosis Diseases & Disorders Ecology RNA interference

Light-activated chemogenetic kinetics (2)

G-tract RNA removes Polycomb repressive complex 2 from genes  9/23/19 Abstract introduction: Polycomb repressive complex 2 (PRC2) maintains repression of cell-type-specific genes but also associates…

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Posted in Adaptations Diseases & Disorders Ecology MicroRNA biogenesis Model Organisms Pheromones

DS Wilson’s view of biophysically constrained life (3)

A Different Kind of Theory of Everything (2/19/19) 1) In 1964, during a lecture at Cornell University, the physicist Richard Feynman articulated a profound mystery…

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