Spin-dependent electron transport (1)

The collaborative efforts of researchers from Palestine, Israel, the USA, Iran and India linked Spin-Dependent Electron Transport through Bacterial Cell Surface Multiheme Electron Conduits (11/8/19) from God’s Creation of energy and the electron transport chain to biophysically constrained viral latency and healthy longevity via control of energy-dependent charge transport in naturally occurring abiotic-to-biotic interfaces, which they also linked to patented applied biotechnology.

For an example of the applied technology, see: pH-Responsive PEG-Shedding and Targeting Peptide-Modified Nanoparticles for Dual-Delivery of Irinotecan and microRNA to Enhance Tumor-Specific Therapy 11/11/19

…pH‐responsive targeting nanoparticles may provide a potential regimen for effective treatment of colorectal cancer.

Simply put, they linked the light-activated assembly of the microRNA-RNA-peptide nanocomplex to all oxygen-dependent life on Earth based on what is known about the Creation of subatomic particles, Creation of the sense of smell in bacteria, and the biogenic Creation of uranium ores.

The Creation of the uranium ores is energy-dependent and biophysically constrained by the physiology of pheromone-controlled reproduction in the bacteria that “eat electrons” and produce the ores.

See:

Biologists discover electric bacteria that eat pure electrons rather than sugar, redefining the tenacity of life  7/18/14

Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits 6/1/17

Stability, Crystal Chemistry, and Magnetism of U2+xNi21-xB6 and Nb3-yNi20+yB6 and the Role of Uranium in the Formation of the Quaternary U2-zNbzNi21B6 and UdeltaNb3-deltaNi20B6 Systems

Who thought it would take more than 54 years to link the Creation of energy-as-information from the Creation of ATP to pH-dependent microRNA-mediated DNA repair via the biophysically constrained Creation of the sense of smell and RNA in bacteria?

See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

For more practical applications of how what is known about the ATP-dependent synthesis of RNA has been linked from the virus-driven degradation of messenger RNA to all pathology, see:

The deficiency of miR-214-3p exacerbates cardiac fibrosis via miR-214-3p/NLRC5 axis 9/10/19

…our findings show that the deficiency of miR-214-3p exacerbates cardiac fibrosis and reveal a novel miR-214-3p/NLRC5 axis in the regulation of cardiac fibrosis.

Reviewed as: A tangled tale of microRNA and cardiac fibrosis 11/13/19

Yang et al. have discovered a novel pathway for FMT via the mir-214-3p/NLRC5 axis. microRNA therapeutics for cardiovascular disease are described [16]. Although they have yet to be tested in clinical trials, they have the potential to affect multiple pathways and profoundly alter disease progression.

See also: Inhibition of human lung adenocarcinoma growth and metastasis by JC polyomavirus-like particles packaged with an SP-B promoter-driven CD59-specific shRNA 11/15/19

See also: miR-155 as a novel clinical target for hematological malignancies 11/11/19

Frank J. Slack’s works directly or indirectly link the light-activated assembly of the microRNA-RNA-peptide nanocomplex to protection of all organized genomes from the virus-driven degradation of messenger RNA and all pathology via Dobzhansky’s claims about amino acid fixation in primate hemoglobin variants.

Nothing in Biology Makes Any Sense Except in the Light of Evolution (1973)

For example, the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla (p. 127).”

For a historical perspective on the refutation of neo-Darwinian pseudoscientific nonsense see:

A mechanism for the association of amino acids with their codons and the origin of the genetic code 3/22/05 and Shelly Copley’s other selected publications

Does it seem likely to anyone else that convergent evolution of enzymatic activities in different structural contexts created an association between amino acids and the first two bases of their codons?

If so, see  see for updates on the biodiversity of human morphological and behavioral phenotypes: HbVar: A Database of Human Hemoglobin Variants and Thalassemias and Slack FJ

Specifically: Non-coding RNA networks in cancer 11/24/17  Ethnic differences were modeled on 3/30/16 in:

Noncoding polymorphisms are the energy-dependent link to prevention of all virus-driven pathology.

See also Slack FJ + microRNA (Items 1-131) and his patents or patent applications

This means microRNAs in human pheromones could be linked from socialization to disease prevention via the microRNA-RNA-peptide nanocomplex and feedback loops.

See: Feedback loops link odor and pheromone signaling with reproduction 11/18/05

See also: Development and validation of exhaled breath condensate microRNAs to identify and endotype asthma in children 11/8/19

…microRNAs can be measured in EBC of children and may be used as potential biomarkers… [of biophysically constrained viral latency, or virus-driven pathology]

Author: James Kohl

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