#SFN2019 to 2012: Hiding the facts (6)

“All normal cells have an absolute requirement for oxygen, but cancer cells can live without oxygen – a rule without exception. “Deprive a cell 35% of its oxygen for 48 hours and it may become cancerous.” Dr. Warburg has made it clear that the root cause of cancer is oxygen deficiency, which creates an acidic state in the human body. Dr Warburg also discovered that cancer cells are anaerobic (do not breathe oxygen) and cannot survive in the presence of high levels of oxygen, as found in an alkaline state.

Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar.

— Otto H. Warburg

Re: “Your hypothesis is just as good as anyone’s.” — Ethan Siegel (Forbes)

Schroedinger’s claims from “What is life? (1944) have been linked from light-activated miRNA biogenesis and biophysically constrained viral latency to healthy longevity via oxygen-dependent ecological adaptations and sympatric speciation.

The claim: “Your hypothesis is just as good as anyone’s.” is made by biologically uninformed science idiots. May God help us all if any of them presented during the 2019 annual meeting of the Society for neuroscience.

For comparison: MiRNAs in milk exosomes  have been linked from miRNAs in semen exosomes  to biophysically constrained viral latency and healthy longevity in all mammals. There’s a model for that. What’s your hypothesis for comparison?

Here’s the latest attempt to obfuscate what is known to all serious scientists about biophysically constrained microRNA-mediated cause and effect.

Search-and-replace genome editing without double-strand breaks or donor DNA 10/21/19

Prime editing offers efficiency and product purity advantages over homology-directed repair, complementary strengths and weaknesses compared to base editing, and much lower off-target editing than Cas9 nuclease at known Cas9 off-target sites. Prime editing substantially expands the scope and capabilities of genome editing, and in principle could correct about 89% of known pathogenic human genetic variants.

Reported as New ‘prime’ genome editor could surpass CRISPR

It’s a huge step in the right direction,” chemist George Church, a CRISPR pioneer at Harvard University, says about the work…

Prime editing is base editing. It links Energy as information and constrained endogenous RNA interference (video) from my 2017 presentation at the Labroots: Precision Medicine Virtual Conference to naturally occurring light-activated carbon fixation and biophysically constrained viral latency to the patent for RNA-guided human genome engineering owned by George Church et al.

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

The Creation of energy as information has been linked from the light-activated assembly of the microRNA-RNA-peptide nanocomplex to biophysically constrained viral latency and the prevention of all pathology via the patent for RNA interference. The claim by George Church that the new ‘prime’ genome editor is a huge step in the right direction actually attests to his interest in the huge profits that could be made via his patent.

See for comparison: Olfaction Warps Visual Time Perception They linked the energy-dependent Creation of enzymes from the Creation of  the sense of smell in bacteria to our visual perception of energy and mass in the context of the space-time continuum via what organisms eat and the pheromone-controlled physiology of reproduction in species from microbes to humans.

See also: Learning from Bacteria about Natural Information Processing 10/15/09 It helped lead to publication of Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

The angstroms to ecosystems approach to base pair editing, now known also as prime edition is the theme of  this entire issue Volume 1178, Issue 1 Natural Genetic Engineering and Natural Genome Editing 10/15/09

There may never be a better example of how serious scientists must refute the pseudoscientific nonsense touted by theorists.

Ten years later, we see this: The brain doesn’t process information, it creates it. Learning does not write new information to the brain, instead it selects from possibilities that are already encoded in the network. Gyuri Buzsáki

See for comparison: Katrina Y Choe et al (2012) showed that the energy-dependent microRNA-mediated Creation of the only achiral amino acid, glycine was linked to dynamically regulated changes in taurinergic gliotransmission and changes in astrocyte morphology.

See: Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms 10/17/19

Genes do not control splicing and they cannot be linked from their magical control of their own expression to information about disease mechanisms. Simply put, all gene-centric theories are pseudoscientific nonsense.

Katrina Y Choe’s  current PI, Daniel H Geschwind may not realize that microRNAs control the tissue-specific regulatory regions he links from eQTLs and spliceQTLs to neo-Darwinian pseudoscientific nonsense in mathematical models of the genetic control of neuropsychiatric disease susceptibility.

For comparison, see: No Genetics without Epigenetics? No Biology without Systems Biology? 10/15/09

A decade of stalled scientific progress could end at this year’s annual meeting of the Society for Neuroscience.

All serious scientists have learned that the virus-driven degradation of mRNA favors rewards linked to more virus-driven degradation of mRNA via alterations in the microRNA-RNA-peptide nanocomplex that link amino acid substitutions in viruses to increased virulence and the increased virulence links mutations linked to all pathology.

Knowledge of how viruses steal the energy required for cell type differentiation of all cell types in all living genera.

See for ages 10+ Subatomic, Periodic, and Cytosis

See also:Hypothalamic microRNA-7 regulates energy homeostasis in vivo

[Virus-driven degradation of mRNA and]

…loss of miR-7 in these different neuronal populations leads to varying degrees of diet-induced obesity.” via what is known to all serious scientists about the hypothalamic pathways regulating energy homeostasis.

MicroRNA-365 promotes cell death by inhibiting IGF-1 pathway

These results suggest that miR-365 may be an important mediator that links oxidative stress and neuronal death….

For comparison, see Reduced expression of brain-enriched microRNAs in glioblastomas

See also: Elevating microRNA-125b to treat traumatic brain injury via multiple target genes in rats

Learn about the link from microRNA-125b and other microRNAs to treatment of TBI and all other brain pathology including cancer

The neo-Darwinian magic of de novo synthesis reared its stupid ugly head again in the context of  MicroRNA regulation of inhibitory synaptic plasticity

…we show de novo synthesis of GABAARα1 occurs exclusively…

Compare claims about de novo synthesis to claims about how to stop it.

Existing technologies, such as chemogenetics are powerful for modulating whole regions but cell-type specific activity modulation….

They used the virus-driven degradation of mRNA to link chemogenetics and kinetics.

For comparison, theorists have no common sense.

See: Quantum common sense

To turn quantum to classical, we don’t need a conscious mind to measure or look; we just need an environment full of stuff. With or without us, the Universe is always looking.

Andrew Jones wrote: By theorists, he’s talking about scientists that support evolution. Kohl is a young earth creationist. Don’t let him fool you.

I responded: By theorists, I’m talking about biologically uninformed science idiots like you who have failed to link chemogenetic kinetics from the Creation of sunlight and water to oxygen-dependent ecological adaptations via the physiology of reproduction and sympatric speciation.

Let’s not discuss this. Maybe theorists won’t notice it is a neo-Darwinian theory killer. Regulation of brain synapses and behaviour by miR-138

…miR-138 is a crucial regulator of pre-synaptic release…with…impact on working memory…

See also: Dysregulation of the aβ degrading enzyme neprilysin (MME) could contribute to Alzheimer’s disease

Dysregulation is caused by the human herpes virus. Those who have not linked the virus-driven degradation of mRNA to Alzheimer’s are losers.

See also: A rodent model of early life stress (ELS) associated with altered miRNA expression in rat hypothalamus

This links stress-related changes in GnRH secretion to failed biophysical constraints on viruses in all jawed vertebrates.

Evolution of gonadotropin-releasing hormone (GnRH) structure and its receptor (2012)

It is very surprising and fascinating that the coordinated evolutionary selection of amino acids participating in binding GnRH has resulted in such perfection, that no substitution with a natural amino acid in any position improves binding potency.

Natural selection for food energy-dependent biophysically constrained codon optimality and all biodiversity was placed into the context of this 6/26/19 Webinar presentation by Ariel Bazzini.

Genome-Wide Study Reveals a Novel Regulatory Pathway: Translation Affects mRNA Stability in a Codon-Dependent Manner

For comparison see this thesis by Andrew Jones, who believes that abiogenesis led to the evolututon of self-replicating ribozymes and all biodiversity on Earth.

Lipid Encapsulation of Self-Replicating Ribozymes

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