See first: The tipping point (revisited): 91K (1)
…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, 2012; Duvarci, Nader, & LeDoux, 2008; Griggs et al., 2013; Monahan & Lomvardas, 2012) in adaptive evolution will certainly be discussed in published works that will follow.
Conservatives start with God’s Creation of energy-as-information in sunlight and link it from the Creation of water to ecological adaptations in all individuals of all species of all living genera. Liberals start with the creation of RNA or worse, the automagical creation of genes.
See: Genetic dissection of assortative mating behavior 2/17/19
Ecologically relevant mating cues (sometimes known as “magic traits” [2,6]) are now predicted to be widespread in nature [6,7], and the last few years have seen considerable progress in our understanding of their genetic basis.
The magic traits were linked to all aspects of cell type differentiation, including sexual orientation, until this study showed how ridiculous the claims of biologically uninformed theorists had become.
If half of human tRNA “genes” are silent, which ones are linked from energy-dependent gene activation to sexual orientation and the physiology of reproduction?
Follow-up of these loci suggested links to biological pathways that involve sex hormone regulation and olfaction.
Food odors and pheromones link olfaction from the microRNA-mediated regulation of sex hormones to sex differences in cell types of species from yeasts to humans via what is known about how the Differential expression of human tRNA genes drives the abundance of tRNA-derived fragments 4/8/19
Here we show that differences in isodecoder tRNA gene expression between different human samples most often do not result in changes in the levels of mature tRNAs, but rather in changes in the abundance of alternative products of the genes, such as immature tRNA sequences, or tRNA fragments that are linked to noncanonical biological functions unrelated to protein synthesis.
Changes in the abundance of alternative products of the genes occur only in the context of the light-activated assembly of the microRNA-RNA-peptide nanocomplex which links fixation of RNA-mediated amino acid substitutions to the stability of organized genomes via what is known about the hydrophobicity of supercoiled DNA.
It’s All About that Base (12/10/14)
See for comparison:
Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.
I am absolutely certain that if you showed this statement to any professor of biology or genetics in any accredited university anywhere in the world that 100% of them would say that “Random mutations are the substrate upon which directional natural selection acts” is a correct and true statement.
He claimed that any professor of biology or genetics at any accredited university anywhere in the world knows more than I know about my established area of expertise: RNA-mediated cell type differentiation.
The final solution to debate:
[MODERATOR NOTE: I’m not going to post more from Kohl until he answers the very direct and simple question posed to him by anon [Andrew Jones], which is whether he (Kohl) believes that RNA splicing can change DNA.]
There is nothing more to be said to anyone who thinks that my beliefs about biophysically constrained RNA-mediated cell type differentiation are important to consider in the context of what others believe or don’t believe.
Serious scientists believe in the facts about energy-dependent cell type differentiation that are known to other serious scientists. None of the serious scientists I have met care what liberals claim or what they believe about the evolution of sex differences.
The food energy-dependent pheromone-controlled creation of microRNAs in milk exosomes links the differentiation of all cell types in all living genera to protection from the virus-driven degradation of messenger RNA in the context of ethnic diversity.
SPLICECODE DATABASE allows others to link food energy-dependent pheromone-controlled cell type differentiation to biophysically constrained viral latency and ethnic diversity via the physiology of reproduction and fixation of RNA-mediated amino acid substitutions.
See also: HbVar: A Database of Human Hemoglobin Variants and Thalassemias reported more than 5 years ago as: Detection of hemoglobinopathies and thalassemias using automated separation systems
The hemoglobinopathies, or Hb variants, are attributable to amino acid substitution(s) in either globin chain. Currently, 1,179 total hemoglobin variants have been characterized.2
More than 1800 variants attest to the facts about biophysically constrained cell type differences in primates and other mammals at the time when Dobzhansky (1973) wrote:
…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla).
See also: DNA Methylation Trajectories During Pregnancy 8/13/19
These results contribute to a better understanding of the biological mechanisms underlying important physiological alterations and adaptations for pregnancy and lactation.
All adaptations in all living genera are energy-dependent and microRNA-mediated in the context of the physiology of reproduction. That context does not start with RNA-mediated gene expression. It starts with the light-activated assembly of the microRNA-RNA-peptide nanocomplex. Starting with gene expression is a way for liberals to excuse their overwhelming ignorance of how physics and chemistry must be linked to biophysically constrained viral latency by energy-dependent cycles of protein folding and degradation.