Screaming viruses and Alzheimer’s (1)

Summary: The future of biology limits claims about mutation-driven evolution to examples of what Richard Feynman referred to as human idiocy (video) in the context of theoretical physicists’ different measures of what happens to the quantized energy that is biophysically constrained in the food organisms eat.

Co-evolution,  amino acid mutation, interacting proteins, protein homology modelling, amino acid sequences, heteromeric complexes, homomeric complexes, Transcriptional regulation, epigenetics, microRNA, epigenetic mechanisms, DNA methylation, histone methylation,  metabolic syndrome, diabetes, cancer, natural models, Alzheimer’s Molecular Networks, Genetic Networks, Clinical Networks, Multiscale Analysis, Cytosis, SchrödingerThe Future of Biology

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

Excerpt:

Taken together, these data provide compelling evidence that specific viral species contribute to the development of neuropathology and AD.

Conclusion:

In summary, we find evidence that links the activity of specific viral species with molecular, genetic, clinical, and neuropathological aspects of AD. Interpretation of these findings in light of the disturbances in G4 and C2H2-TF regulation in the preclinical AD samples that prompted our evaluation of viral activity is supportive of an important role for viral activity, especially Roseoloviruses HHV-6A and HHV-7, in the development and progression of AD.

Reported as: New study suggests viral connection to Alzheimer’s disease

“We didn’t go looking for viruses, but viruses sort of screamed out at us,” Readhead said.

See for comparison: Cytosis (for ages 10+)

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

The virus-driven degradation of messenger RNA has been linked to all pathology in all living genera since the time that Schrodinger published “What is Life?” (1944) He linked the creation of sunlight from its anti-entropic virucidal effects to the physiology of pheromone-controlled reproduction and all extant biodiversity.

See also: Schrödinger at 75 – The Future of Biology – September 2018 

The future of biology limits claims about mutation-driven evolution to examples of what Richard Feynman referred to as human idiocy (video) in the context of theoretical physicists’ different measures of what happens to the quantized energy that is biophysically constrained in the food organisms eat.

Alzheimer’s Disease and all other neurodegenerative diseases have since been placed into the context of constraint-breaking mutations that prevent the quantized energy-dependent creation of fixed amino acid substitutions, which biophysically constrain viral latency.

See: Mount Sinai Researchers Find High Levels of Herpesvirus in Alzheimer’s Disease Brain (video)

See for comparison: Energy as information and constrained endogenous RNA interference Feb 15, 2017 (audio/visual aid)

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.

This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes

 

 

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