#whatislife75 None of today’s speakers linked sunlight from the physiology of pheromone-controlled reproduction in soil bacteria to biophysically constrained viral latency in the context of quantum effects on supercoiled DNA.
Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.) (pp. 73 and 74)
Reprint: with forward by Roger Penrose who co-authored with George F.R. Ellis and Stephen Hawking
How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy? Roger Penrose – 8 August 1991)
None of today’s speakers linked sunlight from the physiology of pheromone-controlled reproduction in soil bacteria to biophysically constrained viral latency in the context of quantum effects on supercoiled DNA. See for comparison:
Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway
1) They used optogenetic tools to precisely control the temporal dynamics of quantized energy-dependent signal transduction pathways and gene expression.
2) They investigated the effects of mutations by modulating the frequency of gene activation.
3) They predictably found a link from light activated microRNA biogenesis and the virus-driven degradation of messenger RNA that links mutations to all pathology.
Simply put, they linked everything known to serious scientists about biophysically constrained autophagy to healthy longevity without mentioning the need for viral latency.
4) They showed that responsiveness to quantized energy-dependent growth factor simulation made transitions between active and inactive conformations, which suggests that virus-driven energy theft does not always cause oncogenically activated proteins to be locked into an active state.
That means light-activated microRNA biogenesis is the obvious regulator of cell type differentiation as indicated in Ultraviolet Absorption Induces Hydrogen-Atom Transfer in G⋅C Watson–Crick DNA Base Pairs in Solution and in UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair. That fact links optogenetics from RNA interference to fixation of amino acid substitutions that differentiate all cell types in all individuals of all species.
See also: Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition and Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk
However, the fact that virucidal light-activated microRNA biogenesis was not linked from hydrogen-atom transfer in DNA base pairs in solution to RNA-mediated sequence selective DNA repair via natural selection for energy-dependent codon optimality was missing from presentations during day 1 of Schrödinger at 75 – The Future of Biology – September 5, 2018.
See the comments on presentations by Ada Yonath, Kay M. Tye, Murray Shanahan, Saul Kato, Leroy Hood, John O’Keefe, Daniel Dennett, Karl Deisseroth, Svante Paabo, Beth Shapiro and Feng Zhang.
Agreed. See: Science, state, and spirituality: Stories of four creationists in South Korea. Our historical study will thus explain why South Korea became what Ronald Numbers has called “the creationist capital of the world.”
The pre-biotic, RNA-dominated world was linked from the creation of virucidal sunlight to the creation of ATP and the creation of RNA by McEwen et al., (1964) What “evolved?”
See “The role of epigenetic alterations involved in sepsis: An overview” Death from C. diff sepsis or mental disability from A. baummannii could be prevented if more people learned about the bacteriophages (viruses) that cause antibiotic resistance.
Thanks for asking. The quantized energy-dependent molecular mechanisms are the same. They biophysically constrain viral latency. That is why the fear of viruses was placed into the context of this cell biology game for ages 10+
Bruce McEwen has been making this case for more than 50 years. See: Redefining neuroendocrinology: Epigenetics of brain-body communication over the life course. In the early 90’s, he taught me to start with gene activation, which led me Schrodinger’s work.
“…as more bacteria and archaean genomes are sequenced” it will become even clearer that neo-Darwinian theorists got it all wrong. Polycombic ecological adaptations require food and viruses steal the food energy to replicate. See: https://advances.sciencemag.org/content/2/10/e1600492
The game continues
Daniel Dennet, who promotes atheism, spoke about the evolution of information. He is an example of how social science has prevented scientific progress that has linked the creation of sunlight to the origin of information. See for example: The origin of information (2)
See also: What is life when it is not protected from virus driven entropy and Energy as information and constrained endogenous RNA interference and A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation
..plants alter microRNA (miRNA) biogenesis in response to light transition.
Let’s answer @danieldennett’s question: When is simplification over-simplification? #WhatIsLife75
See: Food energy and human idiocy. In the reprint edition of What is Life? Roger Penrose asked: “How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?”
Re: Daniel Dennet’s keynote address. Search for the origin of information, which includes Anti-entropic virucidal energy as information
See also: If you do not know who they are making fun of, it may be you, too.
You should probably face the fact that fixation of one energy-dependent base pair change in one amino acid substitution is the link from the EDAR V370A allele in mice to differences and similarities in modern humans found in Asia + New World populations. Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk
For comparison what’s the equivalent distance to our ape cousins?
In the context of an angstroms to ecosystems model, “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla (p. 127).”
Tomorrow’s programme of Schrödinger at 75 #whatislife75 starts at 9 am Dublin time. https://www.tcd.ie/biosciences/whatislife/assets/pdf/Schrodinger_at_75_Delegate_Programme_f.pdf … t:
Sad to see that Linda Buck is missing, especially after learning about the nonsense Daniel Dennett included in his keynote address. See for comparison: Feedback loops link odor and pheromone signaling with reproduction (2005)
To be continued as Schrödinger at 75 Day 2
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.