RNA Velocity (revisited) 2

Summary: I placed the link to the food energy-dependent pheromone-controlled creation of the human-specific EDAR V370A allele into the context of this review of nutritional epigenetics.

See: microRNA 

For example: Insights into the noncoding RNA-encoded peptides

First, microRNA(miRNA)-encoded peptides (miPEPs) are translated from their primary transcripts of miRNA genes and can promote the development of plant roots. Second, a long ncRNA(lncRNA) containing sORF encodes a 90 residues long regulatory peptide. Upon the amino acid response, the lncRNA-encoded peptide reduces the activity of mammalian target rapamycin complex 1 (mTORC1) and promotes muscle regeneration. Third, a circular RNA (circRNA) of the Na+/Ca2+ exchanger gene 1 (NCX1) exon 2 transcript encodes a truncated NCX1 protein exhibiting the Na+/Ca2+ exchange activity. It is also worth noting that the majority of ncRNAs is not translated.

Light-activated microRNA biogenesis biophysically constrains the translation of ncRNAs that are not directly linked from the nutrient-dependent physiology of pheromone-controlled reproduction in soil bacteria to all extant biodiversity on Earth.  Organisms, humans excepted, wisely use the sun’s anti-entropic virucidal energy.

See for instance: Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system

The weekend resurrection of the bacterial flagellum in P. fluorescens clearly exemplifies the wise use of quantized energy from the sun. The cell types that are missing genes create the genes in the context of light-activated endogenous substrates that biophysically constrain the fixation of RNA-mediated amino acid substitutions that are required to resurrect the missing flagellum. The resurrection is required for the organisms to find food and their reproduction is controlled by the metabolism of food to pheromones.

The weekend resurrection of the bacterial flagellum in P. fluorescens  links the fixation of RNA-mediated amino acid substitutions to human populations in vastly different geographical locations.

See: Mitochondrial DNA Sequencing of Middle Neolithic Human Remains of Ling-Ding Site II: Implication for the Social Structure and the Origin of Northeast Coast Taiwaneses

There is a consensus that gene flow characterizing modern Mainland Chinese arrived in Taiwan during the last 400 years, mostly from East China.

See also: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.

There is no experimental evidence of biophysically constrained gene flow in the context of positive selection, which these so-called scientists claim is likely to have occurred circa 20,000 y ago. There is evidence that links the food energy-dependent creation of new genes from light-activated microRNA biogenesis in plants to the frequency of the human-specific EDAR V370A allele.

See: Past 5,000 years prolific for changes to human genome

The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.

It is difficult for serious scientists to not link the conserved molecular mechanisms of quantized energy-dependent RNA-mediated biophysically constrained viral latency from the resurrection of the bacterial flagellum in P. fluorescens to the biodiversity of all morphological and behavioral phenotypes in human populations.  Pseudoscientists, however, will use definitions of terms like mutation and the definition of RNA velocity to make it appear that they know something about cell type differentiation that cannot be learned by students aged 10+ who play the cell biology game “Cytosis.”

I placed the link to the food energy-dependent pheromone-controlled creation of the human-specific EDAR V370A allele into the context of this review of nutritional epigenetics.

Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems

See:

159. Kamberov YG, Wang S, Tan J, Gerbault P, Wark A, et al. (2013) Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell 152: 691-702.

160. Grossman SR, Andersen KG, Shlyakhter I, Tabrizi S, Winnicki S, et al. (2013) Identifying recent adaptations in large-scale genomic data. Cell 152: 703-713.

See for comparison, the current issue of cell and the table of contents. All the articles seem to ignore the facts about biophysically constrained viral latency that link light-activated microRNA biogenesis to all biodiversity. It’s been 5 more years and the lack of scientific progress is manifested here. What good are brain maps outside the context of a model of ecological adaptation in species from microbes to humans?