RNA interference: Targeting the death gene

Human glioblastoma arises from subventricular zone cells with low-level driver mutations

Given that the accumulation of somatic mutations has been implicated in gliomagenesis, studies have suggested that neural stem cells (NSCs), with their self-renewal and proliferative capacities, in the subventricular zone (SVZ) of the adult human brain may be the cells from which GBM originates3–5. However, there is a lack of direct genetic evidence from human patients with GBM4,6–10. Here we describe direct molecular genetic evidence from patient brain tissue and genome-edited mouse models that show astrocyte-like NSCs in the SVZ to be the cell of origin that contains the driver mutations of human GBM.

Reported as: A breakthrough for understanding glioblastoma—origin cells for deadly brain tumors identified

A new study by KAIST researchers identified where the mutation causing glioblastoma starts. According to the study, neural stem cells away from the tumor mass are the cells of origin that contain mutation drivers for glioblastoma, one of the most aggressive brain tumor. This breakthrough research, reported in Nature on August 1, gives insights for understanding why glioblastomas almost always grow back, even after surgery, and suggests novel ways to treat glioblastoma, which was previously thought to be incurable.

Like most cancers, glioblastoma is treated with surgery to remove as much of the tumor as possible, then radiation and chemotherapy. However, it almost always returns in less than a year and its median survival time is only 15 months. Precision therapeutic approaches targeting tumors themselves didn’t lead to any breakthroughs.

Many KAIST researchers continue to advance scientific creationism by linking virus-driven energy theft to the glioblastoma death gene via microRNAs.

Mysterious DNA modification important for fly brain

This is redundant. I posted it to this blog site on August 3, 2018  (See: Evolved to Adapt: A biophysically constrained impossibility)

See also:  Human adaptation to extreme environmental conditions Ecological variations linked to ecological adaptations like the modification in the fly brain and differences in the alleles discussed here are quantized energy-dependent, The energy comes from the sun.

MicroRNA biogenesis links the energy from a change in a base pair to fixation of an RNA-mediated amino acid substitution that differentiates the cell types in a given population. Fixation is biophysically constrained by the physiology of reproduction rather than de novo mutations, which is why the differences are expected to be present at certain frequencies in other geographic locations in the same species via sympatric speciation.

The evidence that links this report of nutrient-energy-dependent pheromone-controlled fixation of one amino acid in populations in flies to humans in the New World and in populations from North and East Asia refutes every aspect of neo-Darwinian pseudoscientific nonsense and Big Bang cosmology. It links the frequency of the human-specific EDAR V370A variant allele to selection for modulation of thermoregulatory sweating and “…the allele’s effect of increasing ductal branching in the mammary gland, thereby amplifying the transfer of critical nutrients to infants via mother’s milk.” In all mammals, environmental selection is manifested in the context of: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

Pattern recognition is essential to understanding how this report on flies ends the False Flag Terrorism in all FB groups. Flies that do not eat do not contribute to species survival via the physiology of pheromone-controlled reproduction. Therefore, even though flies are different than humans, the mysterious DNA modifications important to the fly brain and the human brain are the epigenetically-effected modifications that Feynman referred to in the context of human idiocy  (video) and this video about social science (aka pseudoscience).

On August 13, 2018, Jon Lieff regurgitated his claims from 2014. See: Light in the Brain

Light is not just a metaphor for brain effects and enlightenment. In fact, it is essential for learning, cognition and mood. There are a wide range of direct and indirect effects of light on all aspects of physiology including sleep and wakefulness, hormones, mood, and the ability to learn.

Light-activated microRNA biogenesis biophysically constrains viral latency and all pathology in all cell types of all living genera.

Jon Lieff contributes to the pathology via his failure to report what is known to all serious scientists

See also:  Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene

Academically talented researchers and many medical practitioners typically often live in comfortable surroundings. They don’t like my focus on prevention of all virus-driven pathology and my lack of tolerance for the nonsense touted by biologically uninformed theorists.

When they learn how to prevent all pathology by targeting viruses in death genes, they suffer from a loss of scientific credibility.

See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene

See also: A breakthrough for understanding glioblastoma—origin cells for deadly brain tumors identified

This is a triumph for serious scientists and for scientific creationists from South Korea, the “creationist capital of the world.” After the discovery that human herpes viruses causes Alzheimer’s they will next reveal that the virus-driven degradation of messenger RNA causes all pathology.

Theorists and other liberals will continue to be trapped in their ridiculous tbe forced to unfriend many who live in the “creationist capital of the world” rather than listen to what they have to say.

Author: James Kohl

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