Review article: Human cytochromes P450 in health and disease
Daniel W. Nebert, Kjell Wikvall, and Walter L. Miller
Phil. Trans. R. Soc. B February 19, 2013 368 20120431; doi:10.1098/rstb.2012.0431
Article excerpt (with my emphasis): “With the explosion of molecular biology in the 1980s, it became clear that P450 genes existed in virtually all species—from prokaryotes to rodents and humans [14], and alignment of deduced amino acid sequences led to the first proposal of a gene superfamily nomenclature system based on evolutionary divergence [15]. This evolutionary concept also implied that all CYP genes today arose from a single ancestor, which originated probably more than 3 billion years ago.‘
My comment: This is an open access article. Any advocate of adaptive evolution via random mutations can attempt to find evidence that I could not find by scanning it. Please tell someone when you find it, and if you don’t tell them why you think anyone would believe in such a ridiculous theory as a basis for adaptively evolved human behavior.
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.