John Brunstein toys with the twisted facts about epigenetically effected top-down causation and represents the creation of genes and phenotypes in the context of:
If we find an ORF (open reading frame, a potential protein coding region) near one of our markers, and we find its translated amino acid sequence for example has a high degree of similarity to a known keratin synthase gene, that would make sense and be a good candidate. Our evidence for its involvement would get even stronger if we find this gene expressed as an RNA (or even just a fragment of it, in parlance an EST, Expressed Sequence Tag) telling us that it’s an active gene. If we could then find either amino acid variations in this candidate gene, or variances in its RNA expression level, which correlate with our phenotypic observations of fingernail growth rate, we can become increasingly certain that we’ve found our actual gene contributing to the continuous phenotype.
The epigenetically-effected creation of a gene requires the sun’s anti-entropic virucidal energy to be linked from the open reading frame (ORF) to microRNA-mediated variations in RNA expression levels and the creation of peptides before translation of an amino acid sequence can be correlated with an active gene. The active gene can then be linked to the morphological and behavioral phenotypes of any organism.
I reiterate: Genes do not create themselves. Energy is required for the link to RNA interference and healthy longevity.
The creation of the sun’s energy must be epigenetically linked from a continuous stretch of codons — called an open reading frame — to microRNA biogenesis before natural selection for energy-dependent codon optimality can be linked from the creation of ATP to the creation of RNA. MicrroRNA biogenesis is the obvious link to the biogenesis of everything that lives on Earth. Only then can every aspect of creation be linked from RNA interference to protection from the virus-driven degradation of messenger RNA, which theorists link from mutations to the evolution of new species.
For comparison, see this ridiculous thesis on abiogenesis:
Lipid Encapsulation of Self Replicating Ribozymes by Andrew Jones
… ribozymes have made an interesting niche for themselves in the field of abiogenesis. The evolution of a successful RNA polymerase ribozyme is a lofty goal. While its discovery would not be the be-all and end-all of abiogenesis research, it would represent an important stepping stone between prebiotic chemistry and life. The encapsulation of such a ribozyme is also an important step, as it would enable a system of heredity and evolution through natural selection. Based on progress in current research, it is only a matter of time before that ribozyme is discovered.
See for comparison:
Finally, although we said we’d ignore the third complexity of epigenetics, it’s becoming increasingly possible from a laboratory technical perspective to capture data on things like DNA methylation during sequencing. Analogous statistical approaches to identify differential patterns of epigenetic labeling of particular gene regions correlating to phenotype are of course possible and will likely become more commonplace as the underlying data becomes more commonly available.
The required underlying data and correlations have already been placed into the context of the light-activated assembly of the microRNA-RNA-peptide nanocomplex, which links biophysically constrained viral latency to healthy longevity via the physiology of reproduction and transgenerational epigenetic inheritance of all morphological and behavioral phenoyypes in all living genera.
See for example: Dynamic control of chirality and self-assembly of double-stranded helicates with light (11/7/16)
The unidirectionality of the light-induced motion governs the sequence of programmable steps, enabling the highly regulated self-assembly of fully responsive helical structures. This discovery paves the way for the future development of new chirality-dependent photoresponsive systems including smart materials, enantioselective catalysts and light-driven molecular machines.
Simply put, the creation of anti-entropic virucidal light is required for the light-activated assembly of the microRNA-RNA-peptide nanocomplex, which Bernard Feringa and John Brunstein acknowledge is the link from epigenetic effects on gene activation to chirality-dependent photoresponsive systems, which include enantioselective catalysts and light-driven molecular machines.
Once again, let me make that perfectly clear. Nothing on Earth assembles or reassembles itself without an energy source.
See: A multicellular way of life for a multipartite virus (3/12/19)
When others reported that viruses and viral fragments reassemble themselves, they refuted every aspect of all claims that linked the emergence of energy (Big Bang Cosmology) from mutations to evolution via neo-Darwinian pseudoscientific nonsense.
Darwin put energy-dependent “conditions of life” first, and all serious scientists have continued to do that. Only theorists use terms like QTLs and/or ESTs (Expressed Sequence Tags) to bastardize everything known about how top-down causation links quantum physics to classical physics from the chemistry of protein folding to viral latency and healthy longevity via the physiology of reproduction and Ben Feringa’s claims about Biblical Genesis.