Novartis to shut brain research facility
The FDA Critical Path Initiative directs a more intelligent approach for development of drugs that effect the brain and behavior. It must start with gene activation in cells of hormone-secreting tissue in the brain, which is the most important organ of any organ system involved in behavior. The potential for the use of knowledge gleaned from the molecular biology of olfaction increases each time a report links odors to behavior — as is the case with food odors and social odors in all species from microbes to man. What’s happening now appears to be an attempt to get back to the basic principles of biology and levels of biological organization across species. I’m not sure where researchers first strayed from the gene, cell, tissue, organ, organ-system pathway, but I am happy to see evidence that research may get back on the path that directly links sensory input to brain function and behavior.
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.