Phytoremediation, Microbiome and CRISPR (4)

Foundations for Evidence-Based Policymaking Act of 2017

Ask not what President Donald Trump has done for you. See instead and ask what you can do to help him for God’s sake and for the sake of your Country.

The plan must include: (1) a list of policy-relevant questions for developing evidence to support policymaking, and (2) a list of data for facilitating the use of evidence in policymaking.

The most relevant question appears to be “Why have microRNA biomarkers not been translated from bench to clinic?

The question comes from researchers in Iran, who appear to be trying to help rid human populations in the USA of the horrors that link the virus-driven degradation of messenger RNA from mutations to all diseases.

However, the data and all evidence of biophysically constrained viral latency were placed into the context of claims that

…poor-quality scientific practices are particularly evident in treatment regimens published in “predatory open-access journals.”

See: The Rise of Pseudomedicine for Dementia and Brain HealthThe Rise of Pseudomedicine for Dementia and Brain Health

My 2018 review of nutritional epigenetics and microRNA-mediated protection from all pathology was published in Journal of Genetics and DNA Research as Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 

Pseudoscientists have claimed that Journal of Genetics and DNA Research is a predatory journal. Now, they claim that the link from what organisms eat to the physiology of reproduction and biophysically constrained amino acid substitutions that differentiate all cell types in all living genera may be an attempt to boost the sale of vitamins as supplements.

I specifically mentioned vitamin C and vitamin D because both link the mouse-to-human model of the EDAR V370A variant to the stability of organized genomes in populations from North and East Asia to populations in the New World (during the past 20K years, or less). Apparently, the increased endogenous vitamin C came from ingestion of sago palm-like leaves, which linked the epigenetic landscape of plant growth to the physical landscape of DNA in all living genera via light-activated microRNA-mediated top-down causation. The creation of sunlight, for example, is the link from microRNA biogenesis to plant growth and reproduction in all species that require food to reproduce.

See also: The microRNAs Regulating Vascular Smooth Muscle Cell Proliferation: A Minireview

While the modulation of miRNAs is emerging as a promising strategy for the regulation of VSMC proliferation, most of the effects of miRNAs and their targets in vivo require further investigation.

See also: Ignoring light-activated microRNA biogenesis

The virus-driven cause of all pathology has been missing from ridiculous theories since Darwin (1859) advance his theory based on his claims about “conditions of life,” which he placed before natural selection.

For comparison to light-activated energy-dependent microRNA-mediated cause and effect in the context of “conditions of life,” each brain imaging machine can measure only one dimension (electrical, chemical, or structural) of one sub-skill set.

Almost no consideration has been given to the virus-driven degradation of messenger RNA.

The late Jaak Panksepp put that fact into the context of the social brain. See: Interview with Dr. Jaak Panksepp, Author of Affective Neuroscience: The Foundations of Human and Animal Emotions

“If you don’t understand the foundational level, then you can do brain imaging until you’re blue in the face, but you still will not understand the process at a deep causal level.”

In 2002, Panksepp’s group won the same award that my group won in 2001 for publication of  Human pheromones: integrating neuroendocrinology and ethology

His group published: Comparative approaches in evolutionary psychology: molecular neuroscience meets the mind

He died in 2015, but his group’s most recent publication is Toward understanding cancer stem cell heterogeneity in the tumor microenvironment (2019)

Together, our integrated computational-experimental framework reveals the underlying principles of spatiotemporal dynamics of EMT and CSCs.

Precision medicine: discovering clinically relevant and mechanistically anchored disease subgroups at scale 1/28/19

…society can no longer afford the nearly $1 trillion in annual waste, a major fraction of which is caused by poorly informed medical decisions and misaligned incentives.

Promises, promises, and precision medicine 1/28/19

We must counter the toll of obesity, inactivity, and diabetes; we need to address the mental health problems that lead to distress and violence; we cannot stand by while a terrible opiate epidemic ravages our country; we have to prepare conscientiously for the next influenza pandemic…

Michael J. Joyner, and others like him, may have delayed the scientific progress that has now been linked from energy-dependent changes in amino acids  to a cure for cancer, but no one can stop the progress now.

See: A cure for cancer? Israeli scientists say they think they found one 1/28/19

AEBi is doing something similar but with peptides, compounds of two or more amino acids linked in a chain. According to Morad, peptides have several advantages over antibodies, including that they are smaller, cheaper, and easier to produce and regulate.

By using at least three targeting peptides on the same structure with a strong toxin, Morad said, “we made sure that the treatment will not be affected by mutations…

Instead of attacking receptors one at a time, we attack receptors three at a time – not even cancer can mutate three receptors at the same time.

The creation of the sun’s anti-entropic virucidal energy will continue to be linked from Bacterial self-organization: co-enhancement of complexification and adaptability in a dynamic environment (2003) to Defeating Diseases with Energy 1/9/18 in the context of amino acid substitutions linked to healthy longevity via one energy-dependent base pair change and one amino acid substitution, such as EDAR V370A.

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Author: James Kohl

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