Patented Creation vs Evolution of Disease (9) 

Emerging role of m6 A RNA methylation in nutritional physiology and metabolism 9/2/19

…we summarize the recent progress in the study of the m(6) A methylation mechanisms and highlight the crosstalk between m(6) A modification, nutritional physiology and metabolism.

See for comparison: “Kohl’s Laws of Biology” in Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

At the 2012 Society for Neuroscience Annual Meeting, I learned that light-activated microRNA biogenesis biophysically constrains all energy-dependent downstream effects on organized genomes by protecting supercoiled DNA from viruses, which cause the degradation of mRNA.

I asked a question about that, and looked at all the available information on microRNAs.

From 2001 to 2012,  20934 indexed published works mentioned the term ‘microRNA.’

There are now more than 92000 published works that mention the term ‘microRNA.’ More than 10,000 have been published so far in 2019. And 57 more already have publication dates in 2020.

For updated information on all energy-dependent biophysically constrained microRNA-mediated ecological adaptations, see:

2019 Society for Neuroscience Annual Meeting (abstracts that mention microRNA or related terms) 1-85

Examples:

602.01. Odor preference training in week-old rat pups is associated with changes in protein and non-protein coding messenger ribonucleic acids in odor-encoding mitral cells Canada

602.05. Synaptogenesis and neuronal activation dependent on MeCP2/CaMK2A phosphorylation signaling pathway Taiwan

640.12. Micrornas and histone deacetylase inhibition mediated differentiation of human mesenchymal stem cells into neuronal lineage Republic of Korea

736.15. Spatio temporal dynamics of miRNA mediated regulation of local protein synthesis Germany

683.03. Hypothalamic microRNA-7 regulates energy homeostasis in vivo Switzerland

552.08. MicroRNA regulation of inhibitory synaptic plasticity Aurora, CO

642.23. Behavioral characterization of mice deficient for the mammal-specific microRNA 379-410 cluster

649.08. Profiling of neuronal and microglial argonaute-2 bound microrna during epileptogenesis and in chronic epilepsy reveals cell-type specific contribution to disease
Ireland

036.07. Regulation of brain synapses and behaviour by miR-138

734.26. Unique blockage of host RNAi machinery by the zika virus capsid in fetal NSCs and mouse model
China

076.22. A rodent model of early life stress (ELS) associated with altered miRNA expression in rat hypothalamus Birmingham, AL

126.20. Specific microRNAs (miRNAs) play major roles in human diseases Charleston, SC

236.07. Profiling brain-derived exosomes in the prefrontal-cortex of individuals with major depressive disorder Canada

704.03. Isoform analysis of blood transcriptomic biomarkers for depression in human lymphocytes and hippocampal tissue Chicago, IL

628.04. Programmable modulation of extracellular vesicles Duluth, MN

Taken together, these presentations can be summarized in the context of:

776.21. Blood microRNAs as biomarkers for stress susceptibility or resiliency and treatment response E. J. NESTLER (Session: Poster: 776 – Mood Disorders: Molecular Mechanisms and Approaches)

For the historical perspective on works from E. J. NESTLER, see: Transgenerational Epigenetic Contributions to Stress Responses: Fact or Fiction? 3/25/16

Despite the two extremes of disbelief versus wild speculation, there is growing evidence for at least some contribution of epigenetic regulation—perhaps achieved by miRNAs—in mediating part of the ability of parental behavioral experience to influence stress vulnerability in their offspring.

Growing evidence has turned into overwhelming evidence that energy-dependent biophysically constrained microRNA-mediated viral latency is required for the the transgenerational epigenetic inheritance of healthy longevity.

See also: VISDB: a manually curated database of viral integration sites in the human genome 10/10/19

VISDB is currently the only active comprehensive VIS database, which provides broad usability for the study of disease, virus related pathophysiology, virus biology, host-pathogen interactions, sequence motif discovery and pattern recognition, molecular evolution and adaption, among others.

Molecules do not automagically ‘evolve.’ This database exemplifies how global cooperation among serious scientists is linked from Combating Evolution to Fight Disease to attempts to arrive at ecologically stable World Peace.

For example, researchers from Iran have asked Why have microRNA biomarkers not been translated from bench to clinic? 1/17/19

And, researchers from Israel patented the cure and effective treatment for cancer: Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest 12/25/18

All serious scientists seem to know how to link the light-activated assembly of the microRNA-RNA-peptide nanocomplex to the fact that Phosphorylation orchestrates the structural ensemble of the intrinsically disordered protein HMGA1a and modulates its DNA binding to the NFκB promoter 7/24/19, as predicted in McEwen et al., (1964)

Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

You can place the facts about how phosphorylation biophysically constrains RNA-mediated viral latency into the context of Kohl’s Laws of Biology, or Darwin’s “conditions of life.”

Then, look at this database of more than 1800 human hemoglobin variants.  HbVar: A Database of Human Hemoglobin Variants and Thalassemias

If you cannot link nutrient-dependent pheromone-controlled biophysically constrained viral latency from VISDB: a manually curated database of viral integration sites in the human genome to all biodiversity on Earth via ecological adaptations manifested in hemoglobin variants and ethnic diversity, keep touting your ridiculous theories and be ridiculed by serious scientists from all over the world.

See for an example of what leads to ridicule: Press release: The Nobel Prize in Physics 2019

“for contributions to our understanding of the evolution of the universe and Earth’s place in the cosmos”

These physicists exemplify human idiocy. There is no experimental evidence of top-down causation to support claims about the evolution of the universe.

See:

 

For comic relief, see:

For the required links from physics to chemistry, see:

If you do not know how to link physics and chemistry from molecular epigenetics to biophysically constrained viral latency and all biodiversity on Earth, see:

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements.

The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.

This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA.

Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes.

For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.

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Author: James Kohl

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