The 2019 Nobel Prize for Physiology or Medicine for their discoveries of how cells sense and adapt to oxygen availability was shared by Gregg L. Semenza on 10/7/19. His published works link the Creation of sunlight, water, and oxygen to biophysically constrained viral latency and all biodiversity during the past 5-10,000 years of food energy-dependent pheromone-controlled ecological adaptations. The adaptations include the food energy-dependent pheromone-controlled human ethnic diversity manifested in all morphological and behavioral phenotypes.
The shared award preceded a recent rash of face-saving attempts by those who failed to link the light-activated Creation of microRNAs (microRNA biogenesis) from the physiology of reproduction to the genesis of all biodiversity via biophysically constrained viral latency.
Viral latency is the link to human healthy longevity in the context of more than 1800 hemoglobin variants linked to all morphological and behavioral phenotypes associated with ethnic diversity.
Pseudoscientists and other theorists do not accept the facts about the biophysically constrained food energy-dependent pheromone-controlled human hemoglobin variants. They place ecological adaptations associated with ethnic diversity into the ridiculous context of evolution. Forcing them to stop doing that has been difficult.
The confusion between use of the term ecology and use of the term evolution was reported in: Behind the paper
The predicted wide range of metabolic mechanisms suggests that these organisms may utilize diverse and as yet unidentified substrates.
MicroRNAs are the light-activated endogenous substrates that link the Creation of sunlight, water, oxygen from the microRNA-mediated creation of enzymes to the metabolism of nutrients and from the nutrient-dependent pheromone-controlled physiology of reproduction to ecological adaptations in species from microbes to humans.
That fact is widely known to serious scientists. But, I’m forced to repeat myself, each time another face-saving attempt is made by theorists and biologically uninformed science idiots who missed the facts about healthy longevity and the biogenesis of all diversity, which includes ethnic diversity.
On 10/9/19, 4 more reports attempted to obfuscate what is known about the biogenesis of all life on Earth and the biogenesis of ethnic diversity.
1) Decoding human fetal liver haematopoiesis, reported as: First cell map of developing human liver reveals how blood and immune system develops
Until now, it was unknown [to theorists] precisely how the blood and immune systems develop in humans—a process known as haematopoiesis.
Serious scientists know that the development of all complex systems is energy-dependent and microRNA-mediated.
2) Spliceosomal disruption of the non-canonical BAF complex in cancer, reported as: New research uncovers how common genetic mutation drives cancer
My summary: A recently inserted viral element caused the creation of “junk DNA” that garbled the genetic message and caused the cancer cells to produce an abnormal form of the BRD9 RNA molecule.
No matter how recently the viral element was inserted, George Church et al., patented the cure for the prevention of production of an abnormal form of the BRD9 RNA molecule.
3) Highly recurrent non-coding U1-snRNA mutations drive cryptic splicing in Shh medulloblastoma, reported as: Researchers discover a new cancer-driving mutation in ‘dark matter’ of the cancer genome
…discovered a novel cancer-driving mutation in the vast non-coding regions of the human cancer genome, also known as the “dark matter” of human cancer DNA.
Only biologically uninformed science idiots claim there is “dark matter” in cancer DNA.
4) Analysis of “old” proteins unmasks dynamic gradient of cartilage turnover in human limbs, reported as: Humans have salamander-like ability to regrow cartilage in joints
…microRNAs are also found in humans—an evolutionary artifact…
Creation of the sun links light-activated microRNA biogenesis from biophysically constrained viral latency to healthy longevity in all living genera via the physiology of reproduction. How “old” would the proteins need to be if the microRNAs were a light-activated evolutionary artifact?
See also: Non-coding RNAs – A primer for the laboratory scientist 10/9/19
Advances in molecular genetics have identified several species of RNA that fail to translate – hence the non-coding RNAs. The two major groups within this class of nucleic acids are microRNAs (miRNA) and long non-coding RNAs (lncRNA). There is growing body of evidence supporting the view that these molecules have regulatory effect on both DNA and RNA. The objective of this brief review is to explain the molecular genetic of these molecules, to summarise their potential as mediators of disease, and to highlight their value as diagnostic markers and as tools in disease management.
My summary: Light-activated microRNA biogenesis has been linked from biophysically constrained viral latency to the prevention and to the effective treatment of all pathology.