To unwind the evolutionary history of mcr-containing microorganisms, we used PAML45 to computationally reconstruct the ancestral sequences…two major ancestral gene duplication events were observed, allowing them to survive in wide range of temperatures. Results show that CvP bias (difference between proportions of charged and polar non-charged amino acids) of concatenated mcrABG genes shows significant positive correlation with their OGTs (Person’s R2 = 0.7288, P < 0.000001; Fig. 3c). By reconstructing the ancestral amino acid sequences for each node, we observed a general pattern that the common ancestor of both methanogens and methanotrophs may have evolved from thermal habitats, as nodes near the root are predicted to be thermophilic.
What they claim makes no sense. Only if the energy-dependent thermodynamic differences between proportions of charged and polar non-charged amino acids automagically emerged could the correlations be linked from the emergence of energy to an evolutionary history via the magic of divergent sequences and gene duplication.
Reported as: Behind the paper
The predicted wide range of metabolic mechanisms suggests that these organisms may utilize diverse and as yet unidentified substrates.
Light-activated endogenous substrates link the assembly of the microRNA-RNA-peptide nanocomplex from the physiology of reproduction to divergent sequences and ecological adaptations in all genera.
Differences between light-activated energy-dependent ecology and hecatombic evolution of Thaumarchaeota were explained by the difference between theories and facts. See: “Integrated mobile genetic elements…” and “Spindle-shaped viruses infect…”
Simply put, without the light-activated endogenous substrates that sustains the energy-dependent microRNA/messenger RNA balance, you get virus-driven pathology across kingdoms.
For comparison, the Creation of sunlight, water, and oxygen were linked to our history of ecological adaptations during the past 5-10,000 years in the 2019 Nobel Prize for Physiology or Medicine.
Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene (1991) and A genetic mechanism for Tibetan high-altitude adaptation (2014) reported as: Tibetans inherited high-altitude gene from ancient human 7/2/14
About 8,000 years ago, the gene EGLN1 changed by a single DNA base pair. Today, a relatively short time later on the scale of human history, 88% of Tibetans have the genetic variation, and it is virtually absent from closely related lowland Asians. The findings indicate the genetic variation endows its carriers with an advantage.
One energy-dependent base pair change in one gene links microRNA biogenesis from the light-activated assembly of the microRNA-RNA-peptide nanocomplex (aka the polycomb repressive complex) to biophysically constrained viral latency and all biodiversity via fixation of RNA-mediated amino acid substitutions in the peptides of the nanocomplex via cross kingdom regulation during the past 8,000 years.
Researchers from Israel learned enough about ecology to patent the cure for all cancers.
See also: Turkish schools to stop teaching evolution, official says 6/23/17
Other countries may or may not have started or stopped teaching evolution in schools, but the 1925 Scopes Trial in Dayton, Tennessee led to teaching neo-Darwinian pseudoscientific nonsense about mutations and evolution in public schools in the United States of America.
Teaching students to believe in neo-Darwinian pseudoscientific nonsense instead of light-activated microRNA biogenesis and biophysically constrained viral latency led researchers from Iran to ask: Why have microRNA biomarkers not been translated from bench to clinic? 1/17/19
Here’s what went wrong.
This is the reason that the microRNA-mediated cure for cancer is relatively unknown.
Theorists believe in evolution. They refuse to believe in the Creation of light-activated endogenous substrates that biophysically constrain viral latency.
For example, the 2019 Nobel Prize for Physics was awarded “for contributions to our understanding of the evolution of the universe and Earth’s place in the cosmos”
The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.
Remember this? Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene (1991) and A genetic mechanism for Tibetan high-altitude adaptation (2014) reported as: Tibetans inherited high-altitude gene from ancient human 7/2/14
About 8,000 years ago, the gene EGLN1 changed by a single DNA base pair.
That led to the Tibetan’s high-altitude adaptation. Other food energy-dependent changes in base pair and fixation of amino acid substitutions in organized genomes have been linked from more than 1800 human hemoglobin variants to all morphological and behavior diversity and ethnic differences in the people who have populated the Earth. You can call them mutants if you like, but intelligent people will call you a ignorant racist.
See also: Eukaryotic plankton diversity in the sunlit ocean (2015) for comparison to Virus-mediated archaeal hecatomb in the deep seafloor (2016)
We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.