Patented Creation vs Evolution of Disease (4)

Summary:

The difference between the 2004 Nobel Prize for Physiology or Medicine and the 2004 Templeton Prize to advance human knowledge of the universe through a broad set of intellectual approaches and an ecumenical perspective on spiritual progress can be viewed the context of claims that link the 2019 Nobel Prize for Physiology or Medicine to neo-Darwinian pseudoscientific nonsense about evolution.

For instance, Linda B. Buck shared the 2004 Nobel Prize for Physiology or Medicine and George FR Ellis won the 2004 Templeton Prize

For an update on how their works have been linked by scientific creationists to all extant biodiversity, see: Computational identification of miRNA and their cross kingdom targets from expressed sequence tags of Ocimum basilicum 5/7/19

…O.basilicum miRNAs regulate the key human target genes having significance in various diseases and important biological networks with 10 hub nodes interactions. Thus this study gives the pave for further studies to explore the potential of miRNA mediated cross kingdom regulation and treatment of various diseases including cancer.

The light-activated Creation of microRNAs (e.g., microRNA biogenesis) links microRNA-mediated cross kingdom regulation of cell type differentiation from 28 years of scientific progress and spiritual progress to the the patented microRNA-mediated cancer treatment/cure via the 2019 Nobel Prize-winning works of Gregg L. Semenza.

ICYMI see: Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest 12/25/18  and their “Proof of Concept.”

See also: Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene (1991) and A genetic mechanism for Tibetan high-altitude adaptation (2014) reported as: Tibetans inherited high-altitude gene from ancient human 7/2/14

About 8,000 years ago, the gene EGLN1 changed by a single DNA base pair. Today, a relatively short time later on the scale of human history, 88% of Tibetans have the genetic variation, and it is virtually absent from closely related lowland Asians. The findings indicate the genetic variation endows its carriers with an advantage.

One energy-dependent base pair change in one gene links microRNA biogenesis from the light-activated assembly of the microRNA-RNA-peptide nanocomplex (aka the polycomb repressive complex) to biophysically constrained viral latency and all biodiversity via fixation of RNA-mediated amino acid substitutions in the peptides of the nanocomplex via cross kingdom regulation during the past 8,000 years.

See also: Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy 10/4/19

…we find that interactions between the different Edc3 domains and between Edc3 and RNA in solution are largely preserved in the condensed protein state, allowing processing bodies to rapidly form and dissociate upon small alterations in the cellular environment.

Gregg L. Semenza’s 2019 Nobel Prize recapitulates the works of all serious scientists who have linked the past 5-10,000 years of food energy-dependent pheromone-controlled ecological adaptations to biophysically constrained viral latency and all biodiversity, especially the food energy-dependent ethnic diversity of all human morphological and behavioral phenotypes.

More than 1800 human hemoglobin variants established the importance of fixation of the amino acid substitutions that differentiate all cell types in all living genera.

See: HbVar: A Database of Human Hemoglobin Variants and Thalassemias

For confirmation of how long these ecological adaptations take to be used as examples of how to refute neo-Darwinian pseudoscientific nonsense, see: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants 11/28/12

Reported as: Past 5,000 years prolific for changes to human genome

The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.

When Gregg L. Semenza et al., (1991) linked oxygen sensing from the light-activated microRNA-mediated change in one base pair to altitude-dependent ecological adaptations in human populations via A genetic mechanism for Tibetan high-altitude adaptation (2014), the refutation of neo-Darwinian pseudoscientific nonsense and Big Bang cosmology forced others to begin to use the term ‘adaptation’ rather than ‘evolution.’

The change from mutation-driven evolution to food energy-dependent pheromone-controlled ecological adaptations was subtle but it gathered momentum and took hold across disciplines.

See:  Eukaryotic plankton diversity in the sunlit ocean (2015) and Virus-mediated archaeal hecatomb in the deep seafloor (2016)

The 2019 Nobel Prize in Physiology or Medicine attempts to keep the subtleties and stop the momentum by presenting “…their discoveries of how cells sense and adapt to oxygen availability…” as if  an enzymatic process automagically linked “enhancers” to “…mechanisms developed to ensure a sufficient supply of oxygen to tissues and cells” during evolution.

No experimental evidence of top-down energy-dependent biophysically contrained ecological adaptations suggests that the enhancers and the mechanisms evolved.

More of the overwhelming corruption of the The Nobel Assembly at Karolinska Institutet will be revealed as President Donald Trump changes the focus from vaccines to nutrition in public schools, which will help to ensure the natural protection from virus-driven genomic entropy that our ancestors enjoyed in the relatively recent past — for comparison to claims about millions of years of evolution.

Until then, see the Press release: The Nobel Prize in Physiology or Medicine 2019 10/7/19

Excerpts:

  1. Animals need oxygen for the conversion of food into useful energy.
  2. Oxygen, with the formula O2, makes up about one fifth of Earth’s atmosphere.
  3. During evolution, mechanisms developed to ensure a sufficient supply of oxygen to tissues and cells.
  4. …a protein complex that binds to the identified DNA segment in an oxygen-dependent manner…
  5. …the hypoxia-inducible factor (HIF).
  6. A key physiological response to hypoxia is the rise in levels of the hormone erythropoietin (EPO), which leads to increased production of red blood cells (erythropoiesis).
  7. The importance of hormonal control of erythropoiesis was already known at the beginning of the 20th century, but how this process was itself controlled by O2 remained a mystery.
  8. …VHL is part of a complex that labels proteins with ubiquitin, marking them for degradation in the proteasome.
  9. …under normal oxygen levels, hydroxyl groups are added at two specific positions in HIF-1α (Figure 1). This protein modification, called prolyl hydroxylation, allows VHL to recognize and bind to HIF-1α and thus explained how normal oxygen levels control rapid HIF-1α degradation with the help of oxygen-sensitive enzymes (so-called prolyl hydroxylases).
  10. Figure 2. The awarded mechanism for oxygen sensing has fundamental importance in physiology, for example for our metabolism, immune response and ability to adapt to exercise. Many pathological processes are also affected. Intensive efforts are ongoing to develop new drugs that can either inhibit or activate the oxygen-regulated machinery for treatment of anemia, cancer and other diseases.

My summary: The 2019 Nobel Prize for Physiology and Medicine was placed into the context of drug development instead of natural selection for food energy-dependent pheromone-controlled biophysically constrained viral latency and healthy longevity.

For comparison, The Nobel Prize in Physiology or Medicine 1959 was awarded jointly to Severo Ochoa and Arthur Kornberg “for their discovery of the mechanisms in the biological synthesis of ribonucleic acid and deoxyribonucleic acid.”

The energy-dependent mechanisms have been detailed. For example, in 1964, McEwen et al., published Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Since then, The Nobel Assembly at Karolinska Institutet has done their best to prevent the dissemination of accurate information about biophysically constrained viral latency and the Creation of ATP and the RNA-dependent synthesis of supercoiled DNA.

For example, The Nobel Prize in Physiology or Medicine 1973 was awarded jointly to Karl von Frisch, Konrad Lorenz and Nikolaas Tinbergen “for their discoveries concerning organization and elicitation of individual and social behaviour patterns.”

Organization and activation of behavior is biophysically constrained by food odors and pheromones. Drug development has failed to produce any therapeutic effect that rivals what naturally occurs to biophysically constrain viral latency and aberrant behaviors via change in base pairs and fixation of amino acid substitutions in organized genomes.

See: Feedback loops link odor and pheromone signaling with reproduction (2005) – co-authored by 2004 (Physiology or Medicine) Nobel Laureate Linda Buck.

See also: Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments (2015)

…examination of hemizygous mice with a single Taar allele suggests that the activation of a Taar gene is accompanied by an escape from the peripheral repressive heterochromatin environment to a more permissive interior chromatin environment.

Apparently, the God of Abraham placed the feedback loops that permit the link from the polycomb repressive complex (the microRNA-RNA-peptide nanocomplex) to the peripheral repressive heterochromatin environment into the context of young earth creationism via a more permissive feedback-dependent interior chromatin environment. Whether you believe that or not, the claims about the social organization and elicitation of appropriate or inappropriate behaviors is less important.

Your healthy longevity and the lives of your loved ones has been threatened by the obvious fact that The Nobel Assembly at Karolinska Institutet does not want you to believe any claims made by scientific creationists from every part of the world. The Nobel Assembly at Karolinska Institutet clealy supports drug development, and so do many other organizations that award prizes to those who feed the Big Pharma money machine.

But see what happened after the 2016 Nobel Laureate in Chemistry’s accurate representations of top-down energy-dependent Creation were linked to: The Future of Chemistry – Schrödinger at 75: The Future of Biology

Disabled were walking again, the blind were seeing again, and the death rose from the grave. 2013 was the year in which prophesy from the bible became reality. — De Correspondent dec 2013

Instead of linking his claims from Dynamic control of chirality and self-assembly of double-stranded helicates with light (2016) to drug development outside the context of light-activated DNA repair, the claims have since been linked to the microRNA-mediated cure for all cancers via two patents.

As mentioned earlier in this blog post:

Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest 12/25/18

See also: RNA-Guided Human Genome Engineering

And, remember, The Nobel Prize in Physiology or Medicine 1959 was awarded jointly to Severo Ochoa and Arthur Kornberg “for their discovery of the mechanisms in the biological synthesis of ribonucleic acid [RNA] and deoxyribonucleic acid [DNA].”

Watch what happens when the 2019 Nobel Prize for Chemistry and for Physics are awarded to see if anyone else tries to avoid supporting Bernard Feringa’s claims about the light-activated Creation of all biophysically constrained biodiversity in the context of control of the cell death gene and brain cancer.

See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene (2011)

Together, these results provide an in-depth analysis of miRNA dysregulation in glioblastoma and demonstrate the potential utility of these data in the design of miRNA-regulated therapies for the treatment of brain cancers.

See also: Cortical Circuit Dynamics Are Homeostatically Tuned to Criticality In Vivo 10/7/19

Reported by Kevin J. Mitchell, author of Innate as: -now this looks interesting… and Another nice example of systems biology getting dynamic…

He included a link to this blog post: Beyond reductionism – systems biology gets dynamic 9/14/19

Biology textbooks do not present this view of life and biologists rarely teach it to students. The reasons can perhaps be traced back to the adoption of the mechanistic perspective in Western science, following the successes of Newtonian mechanics, and the accompanying tradition of reductionism.

…this kind of systems perspective provides a much-needed philosophical foundation for biology as a science unto itself.

Kohl’s “Laws of Biology” were presented in the context of Darwin’s “conditions of life.” See: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

No philosophy was required. Conditions of life are energy-dependent and food energy biophysically constrains the pheromone-controlled physiology of reproduction that 2019 Nobel Laureate Gregg L. Semenza placed back into the context of how ecological variation has been linked to ecological adaptations in humans during the past 8,000 years via light-activated biophysically constrained microRNA-mediated viral latency.

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Author: James Kohl

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