Olfaction and microRNA signaling constrain longevity (2)

Olfaction and microRNA signaling constrain longevity (1)

3/30/16

The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.

3/11/19  Clades of huge phage from across Earth’s ecosystems

Phage typically have small genomes and depend on their bacterial hosts for replication…  We conclude that their large gene inventories reflect a conserved biological strategy, observed over a broad bacterial host range and across Earth’s ecosystems.

4/3/19 Reported as: Rarely Seen Giant Viruses Have Been Caught Using CRISPR as a Weapon

Genome reduction as the dominant mode of evolution wrote:

Great study, but please consider that if the ‘huge phages’ have a ‘biology’ that is analogous to that of symbiotic (and parasitic) bacteria, which originated from larger, free-living ancestors by reductive evolution, then, these phages may have also originated following a similar evolutionary pathway (i.e. genome/proteome reduction). See http://precedings.nature.co… and my recent comment on another bioRxiv article: https://www.biorxiv.org/con…

We appear to have reached an academically enforced impasse:

Although viruses are not alive, some people think that viruses evolve like organisms that are alive. Living organisms ecologically adapt in the context of biophysical constraints on energy-dependent pheromone-controlled RNA-mediated amino acid substitutions. The virus-driven degradation of messenger RNA links mutations to the evolution of pathology.

The academic impasse remains:  A universal trend of amino acid gain and loss in protein evolution (2005)

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

I’m not sure how much longer serious scientists will be subjected to the ridiculous claims made by biologically uninformed science idiots who do not know the difference between a mutation and an amino acid substitution.  But the latest report on use of CRISPR as a weapon instead of as an innate system for the defense of bacteria against the virus-driven degradation of messenger RNA is a challenge that may need to be met by someone who is not quite as disgusted as I am by the pseudoscientific nonsense.

I reiterate. This is something only a biologically uninformed theorist would claim: Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

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Author: James Kohl

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