Multigenerational epigenetic inheritance (3)

2 days to Chicago See:

miR-885-5p Negatively Regulates Warburg Effect by Silencing Hexokinase 2 in Liver Cancer 9/12/19

Growing tumor cells possess a distinct metabolic phenomenon that allows them to preferentially utilize glucose through aerobic glycolysis, which is referred to as the “Warburg effect.” Accumulating evidence suggests that microRNAs (miRNAs) could regulate such metabolic reprogramming.

Plan to attend all SFN 2019 presentations and poster sessions that link microRNA-mediated biophysical constrained viral latency  to healthy longevity or link Bruce S. McEwen’s claims about stress to all virus-driven pathology.

You could be one of the first to help others understand top-down causation for comparison to theories about evolution. Indeed, there have been many times when the irrelevant thoughts of neo-Darwinian evolutionary theorists seemed more ridiculous than ever. This is another time.

For contrast to claims about evolution, Xu, et al., (2019) linked light-activated microRNA biogenesis to biophysical constraints via the silencing of hexokinase 2, which stopped the virus-driven Warburg effect. One energy-dependent base pair change and fixation of an enzyme-dependent amino acid substitution is all that’s required for the silencing that has linked microRNA-mediated metabolic reprogramming and fixation of molecularly defined cell types in human populations that vary in more than 1800 human hemoglobin variants and ethnic diversity.

See: HbVar: A Database of Human Hemoglobin Variants and Thalassemias

However, in April (2017) there was still no clear cut definition for genetic variant and mutation.

See: Shaobo Zhang Indiana University-Purdue University Indianapolis 4/4/17

There are a lot of articles talking about genetic variant and more talking about mutations. At this stage if we have a clear cut definition which could clearly differentiate the variant and mutations?

See also: Eugene Daev Saint Petersburg State University 4/4/17

… it seems incorrect completely that “mutation can termed as “polymorphism”. Polymorphism is an existence of at least several forms (variants, alleles etc.). To my mind many of researchers make a mistake when they use term SNP describing in their studies effects only one variant of single nucleotide change.They rather describe single nucleotide variants (mutations) but not a polymorphism. One more time, it is a term describing an existence of many (poly-) forms (morph-). And it seems, we often perceive a mutation as a result of a change, and not the process of changes itself. So,some of the discussion points look like a result of a language imperfection. But not only … 

Eugene Daev linked epigenetically-effected food energy-dependent pheromone-controlled feedback loops to biophysically constrained RNA-mediated cell type differentiation in: [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)] (1994) It was published in the Russian language. Perhaps that is why his claims about biophysically constrained energy-dependent pheromone-controlled feedback loops went virtually unrecognized.

See for comparison, this translation of E.V. Daev, A.V. Dukelskaya, L.V. Barabanova, 2014, published in Ecologicheskaya Genetika, 2014, Vol. 12, No. 2, pp. 3–12.  Cytogenetic approaches for determining ecological stress in aquatic and terrestrial biosystems (2015)

We present a step-by-step recommendations for the analysis of the cytogenetic data and discuss the prospects of applying genetic tests for ecological monitoring, based on the example of analysis using crustacean species.

They linked their cytogenetic data from marine invertebrates to facts about how the Creation of sunlight, water and oxygen link chemogenetic kinetics from energy-dependent changes in angstroms to ecosystems in all living genera. No definitions for genetic variant or mutation were required.

See: Chemogenetic

Clear cut definitions are not required to link chemogenetic kinetics to cell type differentiation in species from microbes to humans. Facts about food energy and the pheromone-controlled physiology of reproduction integrate what is known about neuroendocrinology and ethology.

See: Human pheromones: integrating neuroendocrinology and ethology (2001)

The effect of sensory input on hormones is essential to any explanation of mammalian behavior, including aspects of physical attraction. The chemical signals we send have direct and developmental effects on hormone levels in other people. Since we don’t know either if, or how, visual cues might have direct and developmental effects on hormone levels in other people, the biological basis for the development of visually perceived human physical attraction is currently somewhat questionable. In contrast, the biological basis for the development of physical attraction based on chemical signals is well detailed.

Why doesn’t every intelligent person know that? Is it because they don’t know the difference between a genetic variant, a mutation, and fixation of an amino acid substitution?

Author: James Kohl

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