microRNAs Constrain Virus-driven Pathology (3)

8 hours, 1125 Impressions and 21 engagements may not be the key to healthy longevity. But, President Donald J. Trump’s scientific advisor KB Whaley, and other serious scientists, will ensure the change from claims about mutation-driven evolution to facts about energy-dependent phosphorylation and RNA interference.

The facts about naturally occurring light-activated carbon fixation and protection from viruses via RNA interference were included in this version of the patent for RNA-Guided Human Genome Engineering, which was recognized “A Billion Dollar Baby in Therapy” in “Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy

Historical facts linked to recognition of the difference between allowing unnecessary suffering and premature death compared to preventing it with naturally occurring RNAi.

In 2012, I asked a conference symposium speaker if every aspect of cell type differentiation occurred downstream from the effects of microRNAs.

“Yes, that’s what we’ve learned during the past 10 years.”

On 11/26/19, I asked:

“Has anyone else tried to link “reticulate evolution” from Genomic architecture and introgression shape a butterfly radiation (11/1/19) to biodiversity via “…extensive human non-canonical phosphorylation…” [and] Strong anion exchange‐mediated phosphoproteomics reveals extensive human non‐canonical phosphorylation (8/21/19) outside the context of the physiology of reproduction and biophysically constrained viral latency?

Both questions arose in the context of this statement from McEwen et al., (1964) Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

That claim about ATP-dependent RNA synthesis links the Creation of sunlight and water to oxygen-dependent ecological adaptations in all species via phosphorylation.  That fact was  reported on 11/4/19 as Cell signalling breakthrough opens up new avenues for research (with my emphasis)

Protein phosphorylation, which involves the addition of phosphate groups to proteins, is a key regulator of protein function, and defining site-specific phosphorylation is essential to understand basic and disease biology. In vertebrates, research has primarily focused on phosphorylation of the amino acids serine, threonine and tyrosine. However, mounting evidence suggests that phosphorylation of other “non-canonical” amino acids also regulates critical aspects of cell biology.

Understanding site-specific phosphorylation of amino acids that differentiate all cell types in all individuals of all living genera outside the context of definitions is “ essential to understand basic and disease biology.”

When definitions are used, biologically uninformed science idiots eliminate the requirement for energy-dependent “Strong anion exchange‐mediated phosphoproteomics.”

Biologically uninformed science idiots like to twist the facts about phosoproteomics into something unrecognizable. They might telling you something like this:

MicroRNAs (miRNAs) and other small RNAs encoded by the noncoding regions of DNA are known to control the level of protein production by degrading mRNAs. Changes in these small RNAs may then alter the expression of phenotypic characters.” — Mutation-driven evolution (2013 p. 136) by Masatoshi Nei

They will then take the claims about human non‐canonical phosphorylation and use Hugo de Vries definition of mutation to link everything known to McEwen et al., (1964) about the Creation of energy and RNA to millions and/or billions of years of evolution.

For example, Masatoshi Nei (2013) claimed that mutations are the source of all genetic variation and linked mutations to all forms of evolution.

He obfuscated facts about oxidative phosphorylation and placed the facts into the context of changes in genomic structure that included all these changes: “…nucleotide substitution, insertion/deletion, segmental gene duplication, genomic duplication, changes in gene regulatory systems, transposition of genes, horizontal gene transfer, etc.”

Rather than link light-activated microRNA biogenesis to biophysically constrained viral latency and all biodiversity, he claimed:

Natural selection is for saving advantageous mutations and eliminating harmful mutations.

In the most convoluted way to prevent others from linking light-activated microRNA biogenesis and energy-dependent oxidative phosphorylation to the stability of organized genomes, Masatoshi Nei claimed that mutations caused the evolutionary processes that links natural selection to biodiversity via the type of DNA change.

Other biologically uninformed science idiots loved that. They were taught in public schools to believe in mutation-driven evolution, and Nei’s nonsense confirmed the claims of their scientifically illiterate teachers.

See for comparison: Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition 7/9/16

As if he knew that he would be attacked by scientific creationists, he added that natural selection (initiated by mutation) is an evolutionary process that “…does not have any creative power in contrast to the statements made by some authors.” (p 196).

Scientific creationists could not argue against that fact. They already knew that God’s Creation of energy as information was required to link the Creation of the sun’s anti-entropic virucidal energy and God’s Creation of water, to all oxygen-dependent ecological adaptations via oxidative phosphorylation.

 

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.

The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.

This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes.

For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.

See for comparison:  We are all mutants 3/16/14

…it’s his natural selection-busting theory, which Nei developed in the ’80s and expanded on in the 2013 book Mutation-Driven Evolution, that the researcher wants to see embraced, cited and taught in schools.

I published “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” 4/18/18

I recommend that the Ecosystem card game be used to teach facts about energy-dependent biodiversity to people who have not spent ~40 years working as a medical laboratory scientist — if they want to learn what I learned during my career without learning all the technical details that link quantum physics to quantum biology, which is what happens when any ecosystem is built.

Have fun building your ecosystems based on the fact that all species must eat to reproduce, and dismiss all the ridiculous theories about mutation-driven evolution and Big Bang cosmology.

Author: James Kohl

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