microRNA targeting efficacy refutes ridiculous theories

The biochemical basis of microRNA targeting efficacy

This highly significant somewhat cloaked advancement of a “new scientific truth” follows on the well-worn heels of McEwen et al (1964), whose tracks can help put these findings into perspective. See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

Anyone who did not start with the ATP-dependent microRNA-mediated creation of RNA has failed to link the creation of sunlight from microRNA biogenesis in plants to biophysically constrained viral latency and all biodiversity via the physiology of reproduction. You can already see how this will play out by linking the findings from Bartel’s group to this report in Science Magazine: Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining

If you remember that RNA-mediated DNA repair is quantized energy-dependent, you are less likely to be fooled by theorists. They reported an “Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes

“Using electron microscopy, we determined the atomic structure of a highly divergent ribosome found in mitochondria of Trypanosoma brucei…”

Unless the atomic structure automagically “emerged” and “evolved,” divergent ribosomes found in the mitochondria must be reported in the context of claims about light-activated microRNA biogenesis. That explains the long-awaited claim by Bartel’s group that refutes the pseudoscientific nonsense touted by neo-Darwinian theorists.

ICYMI

“One feature that was not captured in our model is the evolutionary conservation of sites…”

————Addendum

To show how subtle the claims that refute ridiculous theories must be, see the extension of the claim about the evolutionary conservation of sites (with my emphasis).

“…the evolutionary conservation of sites, although its utility is expected to decline as the biochemical model becomes more accurate.

The biochemical model is built on the claims of serious scientists like Bruce McEwen and David P. Bartel.

For example, see: MicroRNAs: Genomics, Biogenesis, Mechanism, and Function (2004)

…most miRNA genes come from regions of the genome quite distant from previously annotated genes, implying that they derive from independent transcription units Lagos-Quintana et al. 2001, Lau et al. 2001 and Lee and Ambros 2001. Nonetheless, a sizable minority (e.g., about a quarter of the human miRNA genes) are in the introns of pre-mRNAs. These are preferentially in the same orientation as the predicted mRNAs, suggesting that most of these miRNAs are not transcribed from their own promoters but are instead processed from the introns, as seen also for many snoRNAs Aravin et al. 2003, Lagos-Quintana et al. 2003, Lai et al. 2003 and Lim et al. 2003a. This arrangement provides a convenient mechanism for the coordinated expression of a miRNA and a protein. Regulatory scenarios are easy to imagine in which such coordinate expression could be useful, which would explain the conserved relationships between miRNAs and host mRNAs. A striking example of this conservation involves mir-7, found in the intron of hnRNP K in both insects and mammals (Aravin et al., 2003).

The introns of pre-mRNAs and miRNA genes regulate protein crowding inside the cell.

See: Intronic miRNA mediated gene expression regulation controls protein crowding inside the cell (2018)

When that fact is placed into the claims of Bruce McEwen’s life history of publications and presentations, it is easier to link the effects of stress on hormones to the affect of stress on behavior, which is required to link quantized energy-dependent changes from angstroms to ecosystems in all living genera.

See also: Psychological Stress and Mitochondria: A Conceptual Framework (Part 1) and Psychological Stress and Mitochondria: A Systematic Review (Part 2) 

Reported as: Cellular ‘powerhouses’ may explain health effects of stress and Olfaction Warps Visual Time Perception

The sense of smell is like a time machine that links our experiences from the past to our behaviors throughout life.

Author: James Kohl

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